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Gregory J Brewer on Calcium Disruptions Wreak Synaptic Havoc

COMMENT Stutzmann nicely extended her studies supporting the calcium-overload hypothesis of AD by providing morphological evidence of spine and synapse loss between the CA3 and CA1 region of the hippocampus in a mouse model of AD. These losses were associated ...

Gregory J Brewer on Calcium in AD Pathogenesis

COMMENT We also have evidence that calcium dynamics are dysregulated in neurons from two-year-old rats (Brewer et al., 2006), so the calcium hypothesis of AD may intersect with the aging in non-familial AD as well. gbrewer 0 Prevention of age-related ...

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