8 RESULTS
COMMENT Eotaxin or CCL 11 is known to recruit eosinophiles. This is thought to indicate a relationship to allergic reactions. Eosinophilic bodies have been reported in Alzheimer's disease cortex on neuropathological exams. They have been described as ...
COMMENT This is potentially a good Alzheimer's model. There may be a number of different toxins or chemicals that contribute to development of Alzheimer's disease. D-galactose is also important as an aging model, and together, aluminum and D-galactose ...
COMMENT I think the locus ceruleus is definitely implicated in Alzheimer’s disease, perhaps in some way mediating synaptic plasticity, which is an early casualty in the Alzheimer’s disease war on the brain. I had treated a number of mice and rats in the early ...
COMMENT The dog models do probably have a lot of advantages over mice, especially since they seem to be endogenous models rather than induced through genetic manipulation. Another large animal model that seems to be largely overlooked is equine motor neuron ...
COMMENT This probably is a very important paper with reference to the progression of Alzheimer disease, if not to the initiating factors. Alzheimer disease could be initiated by death of astrocytes, which are essential in synaptogenesis and maintenance of ...
COMMENT I was quite interested in the regulation of calcium within the endoplasmic reticulum, and subsequent cell death apparently related to calcium toxicity. It appears the presenilin1 and 2 permit calcium regulation, and familial Alzheimer presenilin1 and 2 ...
COMMENT I am optimistic about the introduction of memantine, and think it is more likely to affect a (if not the) basic trigger factor for onset of the disease. I plan to review results of long-term use of memantine in Germany, where I believe it has been used ...
COMMENT It seems Donepezil is relatively safe and can help people with additional problems other than just Alzheimer's disease. stevenbrenner 0 ...
