Delphine Boche, Clive Holmes on Inflammation in Midlife Portends Late-Life Brain Shrinkage

COMMENT This study measured plasma levels of four acute phase proteins (fibrinogen, albumin, von Willebrand factor and Factor VIII) and white cell count in a mixed-race, middle-age group of 1,633 subjects with later assessment of episodic memory and 3T MRI brain ...

Delphine Boche on A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.

COMMENT A Multimodal Drug to Target Alzheimer’s Disease This paper describes the identification of a new RAGE (receptor for advanced glycation endproducts) blocker. Using in-vitro techniques and transgenic AD mice, the authors show that the compound FPS-ZM1: 1) ...

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Delphine Boche, Clive Holmes on Inflammation in Midlife Portends Late-Life Brain Shrinkage

Delphine Boche on A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.

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