Gerhard Koenig, Jean-Francois Blain on Lessons from a failed γ-secretase Alzheimer trial.

COMMENT Bart De Strooper makes a passionate plea to continue exploring γ-secretase as a molecular target for Alzheimer’s disease. In general we agree with his assessment that γ-secretas e has received a bad reputation because of the failures of a few prominent ...

Jean-Francois Blain on Novel γ-secretase enzyme modulators directly target presenilin protein.

COMMENT Amelie Ebke and colleagues' new report on the binding of γ-secretase modulators (GSMs) directly to presenilin is a big step in the understanding of how these small molecules can modulate the enzyme's activity. This study definitively identifies ...

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Gerhard Koenig, Jean-Francois Blain on Lessons from a failed γ-secretase Alzheimer trial.

Jean-Francois Blain on Novel γ-secretase enzyme modulators directly target presenilin protein.

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