3 RESULTS
COMMENT This manuscript shows the value of functional genetics screens in identifying previously unrecognized modulators of GSK3 function, and emphasizes the centrality of dynamic tau phosphorylation as a key mechanism in AD pathology. When the functional role of ...
COMMENT This paper describes an extremely important and exciting result that clearly demonstrates for the first time that both human tau as well as the Drosophila homolog of GSK3b, (a kinase implicated in abnormal tau phosphorylation) are essential for ...
COMMENT Question from Ratan Bhat There have been suggestions that an increase in beta-catenin could mask some the mutation sites within PS1 (Tanzi and Finch in their Science comment), thereby stabilizing PS1, decreasing γ-secretase activity and subsequently β ...
