4 RESULTS
COMMENT Single-cell RNA-Seq studies are an incredible resource for the field, but they don’t always represent the full diversity of cell types in the brain. This study from Lau et al. nicely captures an endothelial cell population and adds insight to gene ...
COMMENT Park et al. use a combination of imaging methods including ASL-MRI and two-photon microscopy, as well as electrophysiology and biochemistry to examine neurovascular coupling in two lines of human-tau-overexpressing mice. Critically, they show that blood ...
COMMENT Both the Holtzman lab and our lab explored the role of microglia in mediating tau-induced neurodegenerative phenotypes in mice. Here, Shi et al. present exciting results of marked neuroprotection in a tau model after microglial ablation. In a different ...
COMMENT This is an exciting paper that nicely explores how Aβ interacts to enhance tau pathology using a model system that overcomes some of the limitations of transgenic mice. In work from our lab, we recently reported that Aβ pathology interacts with tau to ...
