15 RESULTS
COMMENT Aging, the most important risk factor for AD, is linked to reductions in mitophagy. This is a remarkable and outstanding paper since it ties tau phosphorylation and amyloid pathology to mitochondrial dysfunction and defective mitophagy. These findings ...
COMMENT This is a very well done study of broad interest to scientists interested in the link between misfolded proteins and neurodegeneration. There is a great deal of evidence that mitochondria play an important role in the pathogenesis of neurodegenerative ...
COMMENT We also saw a hormetic dose-response curve with toxicity at high doses. At a dose of 4mg/kg, given before symptoms, we see the same protection in the P301S mice that Hochgräfe et al. showed. We showed improved behavioral abnormalities, tau pathology, ...
COMMENT This is a very interesting and important paper. There is substantial evidence for mitochondrial deficits in Alzheimer's disease, however, the mechanism has been obscure. We and others found evidence for an impairment of cytochrome oxidase in both ...
COMMENT The link between these two papers is that VCP mutations have deleterious effects on mitochondria. However, the two groups approach this from different directions. Plun-Favreau et al. studied mitochondrial function in fibroblasts and show that there is ...
COMMENT This is an interesting study that examined the neuroprotective efficacy of JM6, a small molecule inhibitor of kynurenine 3-monooxygenase (KMO). The authors demonstrate that oral administration of JM6 inhibits KMO in the blood, resulting in an increase in ...
COMMENT This manuscript provides further data that point to dysfunctional mitochondria in AD. The authors measured a number of proteins that play a critical role in mitochondrial dynamics and turnover. They found that there is increased dynamin-related peptide ...
COMMENT One other possibility for linking hearing loss to dementia is that both may reflect mitochondrial impairment. Hearing loss occurs with mitochondrial disorders such as MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). Age ...
COMMENT This is an impressive amount of work done by Dr. Yan and colleagues. The results strongly implicate a critical role for Aβ in mitochondria for AD pathogenesis. The finding that blocking the interaction of Aβ with Aβ peptide-binding alcohol dehydrogenase ...
COMMENT I think this is an interesting paper which is consistent with a number of other published studies. The present data are of great interest in that they show that mitochondrial dysfunction precedes the amyloid pathology and NFTs in this triple mutation ...
COMMENT The present paper makes an important contribution to understanding the proteins which are responsible for docking of axonal mitochondria and for controlling their mobility. The authors have identified a role for axon-targeted syntaphilin in mitochondrial ...
COMMENT This is a very interesting paper. It clearly shows that select loss of mitochondrial function in midbrain dopaminergic neurons can lead to a progressive respiratory chain deficiency, which then leads to inclusion formation and loss of dopaminergic neurons ...
COMMENT These two new studies find that deletions in mitochondrial DNA (mtDNA) accumulate with aging, and are found at very high levels in dopamine-producing neurons within the substantia nigra. These are very important studies since they may account for the age ...
COMMENT In the present study, the authors report that a cluster of metabolic defects are caused by mutation in a mitochondrial tRNA (Wilson et al., 2004). They identified a homoplasmic mutation substituting cytidine for uridine immediate 5’ to mitochondrial rRNA ...
COMMENT The recent study demonstrating that tauroursodeoxycholic acid exerts significant therapeutic effects in a transgenic mouse model of Huntington's Disease (HD) is extremely intriguing. This agent was previously demonstrated to stabilize mitochondria ...
