Steve Barger on On The Docket at AD/PD: The Many Crimes of ApoE4

COMMENT Regarding ApoE and autophagy, it appears the mechanism is a surprising one. A few years ago, Dale Bredesen and colleagues strengthened the evidence for ApoE being found intracellularly, in the nucleus and bound to DNA, in fact. As it turns out, the DNA ...

Steve Barger on Vigorous Exercise: Could it Promote ALS in Women?

COMMENT There was a really small difference in the exercise levels reported to confer risk. And I take issue with the claim by the paper's authors, and the reporting in this Alzforum article, that patients and controls differed in the number of times per ...

Steve Barger on Reelin in Aβ Damage?

COMMENT Joachim Herz and his lab have accomplished a milestone in research on the biology of reelin, a protein that has complex biochemistry and genetic contributions to brain development, as well as synaptic plasticity in the adult. Because it is so critical for ...

Steve Barger on Curbing Innate Immunity Boosts Synapses, Cognition

COMMENT This is a fascinating report that seems to help clarify the roles of inflammation-related immune agents in AD. There has been some confusion and controversy arising from the findings that innate immune reactions appear to contribute to the development of ...

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