8 RESULTS
COMMENT Tau is mainly an axonal protein. However, it is also present at dendritic spines and it may play a toxic role there in Alzheimer’s disease and other tauopathies. That toxic role could be the consequence of tau modifications, such asphosphorylation, ...
COMMENT It is well known that the cause of some familial cases of frontotemporal dementia (FTD) is the presence of single mutations in the MAPT gene that codes for the tau protein. Mutated (pathological) tau initiates the disease but the mechanisms for the ...
COMMENT The authors have published a clear and well-performed study on the role of dendritic tau. Several years ago, the dogma was that tau is an intracellular, axonal protein. Now, we know about the multiple faces of tau. Tau could be inside or outside a neuron, ...
COMMENT From a single human gene, many different forms of tau protein could arise. Some of these forms come from alternative splicing of the nuclear RNA transcript, but other forms are the consequence of a post-translational modification—phosphorylation. Recently ...
COMMENT The initial steps for Alzheimer disease can be clearly defined in familial Alzheimer disease (FAD). In this type of AD, mutations in APP and PS1/PS2 genes promote the appearance of β amyloid peptide and the onset of the disease. In FAD, no mutations for ...
COMMENT Comment by Mark A. Smith, Xiongwei Zhu, Hyoung-gon Lee, Rudy J. Castellani, Jesus Avila, Massimo Tabaton, Lawrence M. Sayre, George Perry Peroxidation in Alzheimer Disease: Time to Put the Ducks in a Row Oxidative stress, including carbonyl lipid ...
COMMENT Improvements in medical and surgical procedures have resulted in longer human lifespan. However, surgery could promote collateral damage in neurons due to the use of different types of anesthesia. It has been suggested that exposure to anesthetic agents ...
COMMENT 1136 In the last issue of Cell, Jiang et al. and Yoshimura et al. have published two excellent articles about the role of GSK3 in determining neuronal polarity. In most cases, a neuron has a single axon and several dendrites. This type of neuronal ...
