18 RESULTS
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COMMENT The research conducted by Dr. Saido and his colleagues is long overdue, relevant, and gets to the heart of the problem of using overexpressing APP models. There is now sufficient data to indicate the neurotropic properties of APP and Aβ and why strategies ...
COMMENT The reason for a leaky blood-brain barrier (BBB) with aging may well rest with how dysregulated the HPG axis becomes after menopause and during andropause. We have previously demonstrated that changes in the concentration of sex hormones (gonadotropins, ...
COMMENT Venkataramani and colleagues add to the growing literature regarding the role of APP in mediating stem cell fate as recently reported by Porayette et al., 2009, and Freude et al., 2011. csa 0 ...
COMMENT This paper supports the reproductive-cell cycle theory of aging, which indicates that reproductive endocrine dyscrasia mediates aging in all tissues via altered cell cycle signaling (Bowen and Atwood, 2004; Atwood and Bowen, 2011). The blood-borne factors ...
COMMENT The Alzheimer's Disease and Cancer Relationship These results raise the question of whether amyloid-β peptides might be useful anti-cancer agents. It also adds further support to the idea that amyloid-β has differential effects on pluripotent ...
COMMENT It is nice to see a paper that examines testosterone, as well as estradiol (E2). The data look compelling, although we and others have reported data that luteinizing hormone (LH) appears to be primarily responsible for modulating the processing of AβPP ...
COMMENT Is a Therapeutic Answer to Alzheimer’s Disease Already at Hand? There is one drug that has been shown to consistently improve cognition, both as a prophylactic and as a treatment—that “drug” is 17β-estradiol (see Gleason et al., 2005 for a summary of ...
COMMENT Cycling to Nowhere The paper by Arendt and colleagues presents compelling evidence for DNA synthesis in terminally differentiated neurons of the AD brain, and raises a number of other questions. It is intriguing to speculate whether the increase in cyclin ...
COMMENT Caloric restriction has been shown to extend longevity and delay the onset of many age-related diseases in almost every species tested (Lane et al., 2002; McCay et al., 1935; Weindruch and Walford, 1988). Based on this, it would not be surprising, at ...
COMMENT When all that shines is not golden: Metals in Alzheimer disease This review provides a good summary of the old and new mechanisms by which aluminium, zinc and lead might mediate neurotoxicity, and suggests that multiple downstream mechanism are involved. ...
COMMENT Copper: A Role in AD? Recent exciting findings suggest that copper in drinking water is able to exacerbate the amyloid pathology and an associated learning deficit in the cholesterol-fed rabbit model of Alzheimer's disease (Sparks et al., 2002; ...
COMMENT Coping with Copper—Minute Amount of Metal Plaques in Rabbit Brain The article by Sparks and Schreurs provides evidence that copper is the water contaminant responsible for increased neuronal and extracellular accumulation of amyloid previously reported by ...
COMMENT Copper, Cholesterol and Amyloid-β Deposition Sparks and colleagues report the effect of dietary water quality on the deposition of amyloid plaques in non-treated and cholesterol-fed rabbits. Maintenance of rabbits on tap water versus distilled water ...
COMMENT Chelation as a Therapeutic for Neurodegenerative Diseases In this study by Kaur and colleagues, transgenic mice generated by the embryonic injection of a human H ferritin gene construct driven by the rat tyrosine hydroxylase promoter were shown to be less ...
COMMENT Chelation, Metals and Parkinson’s Disease This paper by Julie Andersen and colleagues highlights the importance of iron in the pathogenesis of Parkinson’s disease (PD). Reduction of reactive iron in the brains of mice either by genetic (overexpression of ...
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