7 RESULTS
COMMENT The study by Sannerud et al. presented clear evidence that PS1 and PS2 are differentially localized, with PS2 being preferentially present in late endosomes/lysosomes. It is an impressive finding that the interaction of AP-1 with PS2, but not PS1, plays a
COMMENT I am very interested in the debate on the pathological effects of PS1 inactive mutations. I rather agree that we should not underestimate the potential role of Aβ43 in the formation of Aβ aggregates. Aβ43 possibly acts as a seed to recruit other Aβ specie
COMMENT Williams et al. revealed the novel ALS/FTD-associated gene CCNF, which encodes cyclin F protein, a component of the SCF E3 ubiquitin-ligase complex. I find this paper particularly intriguing for two reasons. First, the paper clearly indicates that the ubi
COMMENT The article by Guzman et al. provided immunohistochemical evidence that Aβ5-x, one of the N-truncated Aβ species, is more abundantly present in the brains of familial Alzheimer’s disease (FAD) cases than sporadic AD (SAD) cases. Vascular Aβ5-x immunoreact
COMMENT Puglielli’s comments. In addition, APP is mostly distributed in non-raft membrane domains, as is BACE1. We
COMMENT The study by Mattsson et al. provides clear and important evidence that specific generation of Aβ5-x is a general phenomenon under the condition of BACE1 inhibition. The authors emphasize that the Aβ pattern may be useful in monitoring the in-vivo effects
COMMENT The paper by Winton et al. has raised a debate on the significance of intraneuronal Aβ. I generally agree with the opinions by Frank LaFerla, Salvo Oddo, Christian Pike, and Gunnar Gouras et al., arguing that the data are insufficient to disprove the pres
