3 RESULTS
COMMENT This is an intriguing study which links regulation of expression of a gene causative for Parkinson disease (PD), α-synuclein, with several heme metabolism genes. Given that heme is the major iron-binding protein in the body and that brain iron deposition ...
COMMENT This is significant in that it provides a new analytical tool for spatially assessing the presence of iron in cells including neurons. Although iron has been reported to be increased in the substantia nigra, the brain region impacted in the disorder, ...
COMMENT The very interesting review article by Burdette and Lippard addresses recent advances in understanding the molecular mechanisms of metal ion function in the nervous system, including the roles of potassium, calcium, and particularly zinc in various ...
