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Suzee Lee on Before 40, Brain Atrophy in ALS Mutation Carriers?

COMMENT This large cohort of presymptomatic C9ORF72 expansion carriers shows a surprising and interesting new finding of lower praxis scores. Future longitudinal studies will be needed to determine whether the early gray-matter and white-matter deficits also seen ...

Rachel Bennett on Aβ Plaques: Breeding Ground for Toxic Tau?

COMMENT This is an exciting paper that nicely explores how Aβ interacts to enhance tau pathology using a model system that overcomes some of the limitations of transgenic mice. In work from our lab, we recently reported that Aβ pathology interacts with tau to ...

Takaomi Saido on Aβ Plaques: Breeding Ground for Toxic Tau?

COMMENT Based on pathological chronology and genetic evidence, I and others have postulated that Aβ is like the Mafia boss and tau is the hitman. The question is, how does Aβ amyloidosis induce tauopathy? In a previous study, a team led by Brad Hyman showed that ...

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