8115 RESULTS
COMMENT This is an important study, which provides further support for the hypothesis that Aβ pathology can be transmitted by iatrogenic means. Several correlative studies, including a previous one from this group, showed that patients who had received ...
COMMENT I find this article quite interesting. In this follow-up study, the authors examined aliquots of human-derived growth hormone used decades ago and found they indeed contained Aβ. More importantly, they showed that when these materials were injected into ...
COMMENT This paper proves that the hGH preparation contained Aβ contaminants that have seeding properties, and confirms the concept of iatrogenic CAA. We had also found Aβ and tau contaminants in the French hGH preparations (Duyckaerts et al., 2018). It will be ...
COMMENT Purro et al. have published an important study. There is much scientific value in this work, but I will focus on the nature of the “proteopathic seeds” that template Aβ amyloidosis, and why this question is critical to human health. Three sobering studies ...
COMMENT This is an important control and confirmation of the previous human transmission observations by this group. I am not surprised that Aβ in the hormone extracts seeded cerebral amyloidosis in these mice, since it is exactly what transmission studies in ...
COMMENT This is a brilliant study that shows us just how well Flortaucipir PET matches neuropathologically mapped tau. The correlations were strong as tested in a wide variety brain regions. The study clearly adds to our knowledge of Flortaucipir PET performance. ...
COMMENT Stunning achievement, combining genome-wide SNP analysis with RNA-Seq—protein-coding; pseudogenes; lncRNAs; sncRNAs—in 13 human immune cell types, primarily lymphocytes. Once cis eQTL, i.e., SNPs that affected expression of a gene on the same chromosome, ...
COMMENT Microglial scRNA-Seq was performed across the mouse life span from E14.5 through P540. After cluster analysis, care was taken to specify at what age, and where, in the brain varied clusters were detected. It was observed that maximal microglial ...
COMMENT These are exciting findings, with implications for α-synuclein therapeutics and Parkinson's disease. Researchers have known that α-synuclein interacts with lipids for some time, but few therapeutic strategies have exploited this property. The two ...
COMMENT I have an academic soft spot for this study, as it perfectly validates some of our original findings on neurotoxic A1 reactive astrocytes in human AD and rodent tau models (Liddelow et al., 2018; Shi et al., 2018). In extensive work, Hui Zheng’s lab ...
COMMENT The Schmiedel et al. paper offers similar highlights to those found in Hammond et al.: Sex differences. Disease differences, though this time done by comparing cell-type specific transcriptome data sets with already-available GWAS data sets. Done in ...
COMMENT This is a very exciting piece of research. I’ve eagerly awaited these data sets. A few points that make this work so novel, and will ensure that it is cited widely in the coming years: Single-cell microglia analysis—obviously interesting and follows ...
COMMENT This is an important paper, which adds to the likelihood that APP functionally interacts with cellular iron levels. In this case, miR346 inhibits APP translation through the IRE motif at the 5'UTR. Curiously, this forecasts changes in APP levels, and ...
COMMENT The intense focus of the AD research community on the function of the APP gene has revealed an astonishingly complex combination of regulatory mechanisms involving transcription, mRNA stability, translation, and protein stability. Many of these mechanisms ...
COMMENT This research truly validates the late Prof. Susan Lindquist's novel idea of using yeast to study neurodegeneration—an idea which in the early 2000s was considered "crazy" even by people in her own lab (see New York Times article). And the ...
