9237 RESULTS
COMMENT Some years ago, after Fred had given a wonderful talk on Alzheimer’s disease, I wrote to him to ask if I could use some of his diagrams. He responded by sending all his carefully drawn slides, saying we could use them without restriction. That is so ...
COMMENT This is an interesting and useful study for at least two reasons: Firstly, it adds to the four previous studies on risk of subsequent dementia for those treated with antivirals, specifically antiherpetics, and secondly, the data, along with the previous ...
COMMENT In this interesting new study, Lopatko Lindman et al. examined the impact of antiviral treatment on long-term risk of dementia in a large Swedish registry-based cohort, focusing on herpes simplex virus (HSV) and varicella zoster virus (VZV), two highly ...
COMMENT The study by Karin Lopatko Lindman et al. is an excellent observational cohort study that supports the idea of a potential weak association between herpes diagnosis, antiherpetic treatment, and subsequent incident dementia. People exposed to routine ...
COMMENT Fred van Leeuwen: From vasopressin to Alzheimer’s disease. From the beginning of his scientific life, Fred’s field of expertise has been immunohistochemistry. At that time (the mid ’70s) this technique was still in a pioneering phase in neuroscience. Fred ...
COMMENT This is a very well-done study and one of the largest showing that not only herpes simplex (HSV), but also herpes zoster (VZV), increases the risk of dementia, and that treatment lowers that risk significantly. This and other European studies are ...
COMMENT Our roads crossed during the first years of my postdoctoral project. In hindsight, I think that Fred and I probably started working around the same time on ubiquitin, Fred as a principal investigator in Amsterdam and me as a postdoctoral fellow in ...
COMMENT It is with great sadness and dismay that we heard of the death of our valued cooperation partner and friend Fred van Leeuwen, Ph.D. Fred has shaped Alzheimer's research for decades with innovative ideas and unique concepts, pushing science forward to ...
COMMENT The Holtzman group's anti-ApoE antibody (HAE-4) recognizes human ApoE4 and ApoE3. This antibody binds specifically to non-lipidated human ApoE4 and ApoE3 and, when delivered to ApoE4-expressing mice, reduces Aβ deposition (Liao et al., 2018). These ...
COMMENT The new genome-wide association study by Bellenguez et al. identified 75 risk loci associated with AD, of which 42 were novel. This effort was able to discover so many new loci primarily by increasing the sample size of the study, with the number of ...
COMMENT This paper by Monica Xiong and colleagues elegantly demonstrates how anti-human ApoE immunotherapy efficiently reduced vascular and parenchymal amyloid deposits in the 5XFAD model expressing human ApoE4, whereas an anti-Aβ immunotherapy had no effect on ...
COMMENT This an impressive and important paper. Key to this study is the development of the HAE-4 anti-ApoE antibody and its specificity for poorly lipidated forms of ApoE, which are preferentially incorporated into amyloid plaques. The study is the ...
COMMENT GWAS finds regions in the genome, not genes per se. The difficult part is actually finding the underlying causal variant. However, we are obtaining a full picture of locations in the genome that may harbor important genetic variants that would facilitate ...
COMMENT This work is clearly a tour de force, but also a good example of what can be achieved through broad collaboration. It is worth noting that identifying genes or genetic regions just for the sake of it is useless. The important aspect is that the genes ...
COMMENT Undertaking genetic studies to identify causal factors for Alzheimer’s disease (AD) requires sufficient sample size and detailed analysis. In this study led by Bellenguez and Lambert et al., genome-wide association analysis (GWAS) based on imputed array ...
