8829 RESULTS
COMMENT This study extends prior cell culture, sub-cellular biochemical, animal, and human studies that show presenilin 1 mutations have biological consequences. As demonstrated nicely here, the stem-cell-derived model can facilitate studies of how specific PS1 ...
COMMENT This is an interesting paper that reports that Aβ17-40 (also known as P3) forms β-sheet amyloid fibrils with properties like that of its longer sibling, Aβ1-40. Aβ variants at the carboxyl terminus and amino terminus have been extensively investigated ...
COMMENT This paper shows that, in a very large number of presenilin-1 E280A mutation carriers (Columbian kindred) and age-matched controls, plasma NfL is higher. Statistically, cross-sectional values begin to diverge ~22 years before expected age of onset but ...
COMMENT This is a very clearly and thoughtfully described study of plasma NfL in the Colombian family with the presenilin-1 E280A mutation. Given the large age range (8 to 75) of this cohort and large number (>2,000) of enrolled mutation carriers (impaired and ...
COMMENT This is an interesting study as it provides valuable information on the nature of the tau aggregates that underlie the fluorescent signal one detects in this seeding assay. In addition, it provides a very useful characterization of how fluorophores linked ...
COMMENT This impressive study demonstrates the potential of combining proteomics with detailed pathological phenotyping to yield important mechanistic insights into the causes of dementia. Using this approach, the authors elegantly demonstrate a number of ...
COMMENT Johnson et al. provide fascinating findings on mass spectroscopy proteomics in brain tissue from over 2,000 pathologically defined individuals with AD, other dementias, and controls as part of the multicenter Accelerating Medicine Partnership for AD (AMP ...
COMMENT We have read with great interest the important new paper from Burberry and colleagues demonstrating the influence of gut bacteria on the ability of the C9ORF72 hexanucleotide repeat to suppress inflammation in the brain (Burberry et al., 2020). We agree ...
COMMENT There really never was a question that the conformational structure of the FRET-based bioreporter would be the same as tau aggregates in the brain–the former is short and has large fluorescent proteins attached, the latter is full-length and has ...
COMMENT Having speed-read the tau controversy, I would conclude that the findings of the Mandelkow group are reasonable within the context of their experimental conditions. The problem is one of comparing apples and oranges, as pointed out by Diamond et al. The ...
COMMENT Understanding mechanisms of tau aggregation continues to be an important avenue of ongoing research. A challenge we all face in modeling tau aggregation as it occurs in AD and ADRD is that the milieu of the neuron is much more complicated than that ...
COMMENT This is an excellent paper from the BioFINDER-2 study team. Using their large sample size, they demonstrate the high specificity of RO-948 for confirming a diagnosis of AD in patients presenting with amnestic dementia. They found that a temporal ROI ...
COMMENT Using a mutant C9ORF72 mouse model, Burberry et al. report on the impact of the gut microbiome on disease progression in ALS. They show that fecal transplant using gut microflora from mice with loss of both (-/-) alleles of C9ORF72 raised in a protective ...
COMMENT This new manuscript from Kevin Eggan and colleagues is surprising and remarkably important, with direct implications for therapies that are currently in development for ALS and FTD. Mutations in the C9ORF72 gene are the most common cause of ALS. This ...
COMMENT This study represents an impressive undertaking by the BioFINDER-2 team. It represents the largest RO-948 study published to date, and one of the largest studies investigating the ability of tau PET imaging to differentiate clinical phenotypes. Among the ...
