8612 RESULTS
COMMENT This is an interesting study providing useful data for the understanding of brain endothelial function in both physiological and pathological conditions. The study shows that in different models of neurodegenerative diseases, the transcriptional responses ...
COMMENT This exciting study provides a comprehensive data resource on the molecular underpinnings of brain endothelial cell dysfunction. It builds on the group's prior work providing a healthy blood-brain barrier (BBB) transcriptome, an already incredibly ...
COMMENT This is a noteworthy study by the Daneman lab comparing the transcriptional profiles of mouse blood-brain barrier (BBB) endothelial cells (ECs) with those in other organs of the body (i.e., heart, lung, kidney, and liver) using RNA-Seq method and an ...
COMMENT This is an exciting paper from the Daneman group that studies how the unique characteristics of endothelial cells (ECs) around brain capillaries change in different types of pathology, in such a way that the ECs start to resemble ECs on peripheral ...
COMMENT The authors should publish the full study as soon as possible. The observed effect size is relatively small, and is only slightly greater than the minimal clinically important difference of ADAS Cog. So, I don't view this as a breakthrough. If they ...
COMMENT This is an interesting finding that reveals further clues about the interplay between Aβ, BACE1, and tau. The use of in vivo two-photon imaging in APP/PS1 mice either with or without tau is a powerful technique that allows individual plaques to be tracked ...
COMMENT This is an interesting article that provides further evidence that vascular risk factors are independently associated with brain volume loss (a likely correlate of neurodegenerative processes). Interesting aspects of this paper include the finding that ...
COMMENT There are larger and more detailed studies that have previously explored vascular risk with brain volumes and white-matter damage across mid- to later life in greater depth, and the results of this study are in line with the direction previously reported ...
COMMENT This is a very interesting finding, and parallels recent findings from the Kaczorowski lab (in mice). In our recent study, we took the approach to map modifiers that protect/delay onset of cognitive deficits in a genetically diverse population of ...
COMMENT A few months ago, some people were ready to close the book on NSAIDs based on the results of the INTREPAD trial led by John Breitner at McGill, which found that daily naproxen use by asymptomatic people in their 60s at high risk for Alzheimer’s disease ...
COMMENT This is a very interesting study showing that mortality from neurodegenerative diseases, particularly dementia, was higher among former professional soccer players than among controls from the Scottish population. Data based on death certificates and also ...
COMMENT We’d like to pick up on several of the interesting themes raised in these studies as based on our own work in this area. In a study of 1,557 brains in the NACC v 10 database (which we presented at AAIC, 2019, and which we’ve now submitted) we found that ...
COMMENT Park et al. describe a new small molecule targeting the NF-κβ pathway that is able to restore microglia dysfunction, improve cognitive impairment, and foster Aβ clearance in two mouse models of Alzheimer’s disease. The authors showed that N,N' ...
COMMENT This very nice and extensively documented report demonstrates the efficacy of a new small molecule (DAPPD) that inhibits NF-κB pathway-mediated activation of microglia by Aβ to restore microglial amyloid clearance in two lines of APP/PS1 mutant mice. They ...
COMMENT Park and colleagues report that targeting the inflammasome with a small molecule mitigates inflammation and cognitive behavioral deficits in mouse models. This and other groups have advanced the field by focusing on a specific signaling pathway rather ...
