9505 RESULTS
COMMENT An objective way to quantify aging is a prerequisite to designing targeted interventions for the doomed biological process, which invariably leads to the end of life. In this new study, Sayed et al. devised an inflammatory aging clock, properly named iAge ...
COMMENT First and most important, kudos to the authors for taking on the project. It's a great concept and we end up with a really useful dataset that others can use to test ideas about AD... and aging. From the methodological point of view, I do have some ...
COMMENT There are many useful findings in this study, such as differences in gene expression involving energy metabolism and synapse pathways as indicators of healthy aging vs. “escalated” inflammation/immune responses in AD, and the presence of “AD-like” gene ...
COMMENT This article is an important reminder that dementia does not only affect older adults, but younger adults between the age of 30 and 64 as well. Most individuals with young-onset dementia were between the ages 45 and 64; between ages 30 and 44 dementia was ...
COMMENT The greatest burden of dementia is found in the elderly, hence for clinicians, dementia, and thereby the diagnostic approach, is focused on diseases of the elderly such as Alzheimer’s disease and cerebrovascular disease. Young-onset dementia (YOD), ...
COMMENT This paper, based on a comprehensive review of published papers that contain information about prevalence of dementia in persons younger than 65, and the accompanying editorial, provide good information about the relative frequency of dementia in younger ...
COMMENT The vast majority of research in the dementia field has focused on late-onset dementia. Historically, initial studies focused on estimating the prevalence and incidence, followed by identifying risk factors and biomarkers, and assessing best methods for ...
COMMENT I wish to congratulate the authors for their exciting publication and valuable contribution. Meningeal B cells have been hiding in plain sight, and yet they have received little attention. I believe that our studies will pave the way for a fertile line of ...
COMMENT This is an interesting paper that adds to recent work demonstrating that tissue-resident B cell progenitors and mature B cells reside in the dura matter, and it highlights their potential homeostatic functions. Additionally, these data add support to the ...
COMMENT In this paper, the authors provide a comprehensive characterization of human prefrontal cortex tissue from 12 Alzheimer’s disease and eight control brains by both single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-Seq) and RNA ...
COMMENT This work is an important step toward filling three important gaps in the study of gene expression alterations in Alzheimer’s disease: Understanding whether gene expression alterations observed in previous studies based on tissue analysis (bulk RNA-seq) ...
COMMENT This excellent, definitive, and timely study, in a large sample of individuals with Down's syndrome, carefully examines if APOe4 effects are consistent with findings in non-DS populations. This work is highly important. It not only confirms the ...
COMMENT The findings here are in keeping with previous studies that have shown the effect of APOE E4 alleles in aging adults with Down’s syndrome, with an earlier onset of cognitive decline. The addition of biomarker data in this report confirm it may be ...
COMMENT This important paper from the Fortea and Zaman groups further strengthens the notion that AD in DS shares many similar features to other forms of AD (i.e., sporadic and autosomal-dominant AD), including the increased risk associated with the APOE4 allele. ...
COMMENT This report builds on compelling data from multiple laboratories demonstrating that PrP preferentially binds to soluble Aβ aggregates, weakly interacts with Aβ fibrils, and shows little affinity for Aβ monomers (reviewed in Corbett et al., 2020). The ...
