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Thomas Vogels on Widely Used Tau Seeding Assay Challenged

COMMENT This is an interesting study as it provides valuable information on the nature of the tau aggregates that underlie the fluorescent signal one detects in this seeding assay. In addition, it provides a very useful characterization of how fluorophores linked ...

Bradley Hyman on Widely Used Tau Seeding Assay Challenged

COMMENT There really never was a question that the conformational structure of the FRET-based bioreporter would be the same as tau aggregates in the brain–the former is short and has large fluorescent proteins attached, the latter is full-length and has ...

Lary Walker on Widely Used Tau Seeding Assay Challenged

COMMENT Having speed-read the tau controversy, I would conclude that the findings of the Mandelkow group are reasonable within the context of their experimental conditions. The problem is one of comparing apples and oranges, as pointed out by Diamond et al. The ...

Benjamin Wolozin on Widely Used Tau Seeding Assay Challenged

COMMENT Understanding mechanisms of tau aggregation continues to be an important avenue of ongoing research. A challenge we all face in modeling tau aggregation as it occurs in AD and ADRD is that the milieu of the neuron is much more complicated than that ...

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