7977 RESULTS
COMMENT I think the RiboTag system is an elegant approach to profile ribosome-associated transcripts in a minimally invasive fashion as demonstrated by Kang et al. and other labs who have successfully applied the approach to study diverse microglia phenotypes ...
COMMENT This is an innovative study using the RiboTag technology to capture transcripts while they are being translated, potentially avoiding unwanted bias when microglia are isolated for profiling. The authors have generated publically accessible translational ...
COMMENT Chatila and colleagues have identified a role for BACE1 in the regulation of hippocampal neurogenesis in adult mice, raising a new concern regarding the use of BACE inhibitors for the treatment of Alzheimer’s disease. The increase in undifferentiated ...
COMMENT The findings of Chatila and colleagues in BACE1 knockout mice—namely increased proliferation, decreased neurogenesis, and accumulation of undifferentiated neural precursor cells (NPCs) in the subventricular zone of the adult hippocampal dentate gyrus (DG) ...
COMMENT This is an interesting paper adding to our understanding of physiological BACE1 functions. It demonstrates that BACE1 controls neuronal differentiation. This study is different from a previous paper by Riqiang Yan (Hu et al., 2013) in that it now analyzes ...
COMMENT Imaging synaptic density opens a new avenue to assess neurological conditions, in particular neurodegenerative conditions such as Alzheimer’s disease where a synaptopathy, either as a consequence of the toxic effects of aggregated proteins and/or other ...
COMMENT This is very impressive and important work. I commend the authors for their well-executed study and the PET methodology is truly excellent. The authors demonstrated for the first time reduced synaptic density in the hippocampi of living persons with early ...
COMMENT PET measurements of presynaptic and postsynaptic density would greatly advance the scientific study of Alzheimer’s disease and related disorders. The Yale group has developed this promising 11 C-labeled ligand to assess presynaptic density. They have ...
COMMENT We have previously reported heterochromatin decondensation and global transcriptional upregulation, affecting both protein coding and non-oding genes, in Drosophila tauopathy models. Moreover, we believe that tau-induced heterochromatin decondensation is ...
COMMENT These results are exciting and promising not because they remove plaque, but because they neutralize the cytotoxicity of the Aβ profibrils, one of the soluble aggregates of this protein, that with the soluble oligomers are responsible for killing the ...
COMMENT Overall results are impressive. Whilst it will be important to see the results of a subanalysis examining the impact of APOE4 on outcome, it seems unlikely that this could account for 80 percent of individuals becoming amyloid-negative. The potential ...
COMMENT I am curious what other people think about the PET scan results. In my experience doing in vivo optical imaging in mice, and from my read of the literature, I don't see strong evidence that pre-existing amyloid plaques can be made to completely ...
COMMENT These results presented at AAIC are exciting and have major implications for the AD therapeutics field. The authors used a previously published sensitive immunoassay capable of detecting Aβ oligomers in human CSF samples (Yang et al., 2015) to measure CSF ...
COMMENT The concept of “VCAM-1 opening the door to aging” is very interesting and fascinating. Aging has been associated with a low‐grade inflammatory status of the immune system, commonly called “inflammaging,” a contraction of inflammation and aging (Franceschi ...
COMMENT We share the authors' enthusiasm regarding the possible role of CNS lymphatic clearance in Alzheimer’s disease. With novel pharmaceutical approaches or lifestyle changes, one might even be able to stem the decline in lymphatic function that occurs ...
