8546 RESULTS
COMMENT Both the Holtzman lab and our lab explored the role of microglia in mediating tau-induced neurodegenerative phenotypes in mice. Here, Shi et al. present exciting results of marked neuroprotection in a tau model after microglial ablation. In a different ...
COMMENT This seminal work demonstrates a bridge between innate and adaptive immune influences on the CNS. Over the past few years, many studies have emphasized the critical role of mononuclear phagocytes and conventional T cell (CD4+/CD8+) involvement in learning ...
COMMENT For centuries, the brain was viewed as an immune-privileged organ fully isolated from the periphery and the interactions between the immune system and central nervous system (CNS) were classically associated with pathological conditions. This traditional ...
COMMENT Human brain organoids have emerged as a promising model to study neural development and neurological disorders, including Alzheimer’s disease. However, it remains challenging to generate a bona fide model that recapitulates the complex structure and ...
COMMENT This study is a step forward to a more physiologically relevant brain organoid model. Dr. Park’s team elegantly showed a vascularized human cortical organoid (vhCO), which displays blood-brain-barrier (BBB) characteristics and vasculature-like networks in ...
COMMENT Cakir et al. have established a brain organoid model carrying a vascular-like system that functions in implanted mice. This system is unique in many ways compared with previous published brain organoids, and it has tremendous potential for testing ...
COMMENT Since the milestone paper in 2013 by Lancaster et al., cerebral organoids have provided a means to generate complex, three-dimensional, in vitro models of human neurons recapitulating, in part, neuronal diversity and aspects of the physical architecture ...
COMMENT This article by Cakir et al. provides what we believe to be a very important method for modeling a human brain in a dish with a functional vascular-like network. In this paper, Dr. Park and his colleagues demonstrated that it is possible to obtain ...
COMMENT Cortical organoids offer powerful technology for modeling brain development and other neurological disorders. However, cortical organoids have a high degree of inter-organoid variability, lack microglia and vascular cells, and often contain necrotic ...
COMMENT Adenosine A2A receptors play key roles in neurological disease and might be promising therapeutic targets for dementia‐ related cognitive decline. However, the exact mechanisms underlying the effects of A2A receptors in disease are unclear. Here, Carvalho ...
COMMENT Better Than Coffee: A More Specific Adenosine A2A Receptor Antagonist Shows Preclinical Promise Against Neurodegeneration in Alzheimer’s Disease and Other Tauopathies This team led by Dr. David Blum has been pursuing specific adenosine A2A receptor (A2AR) ...
COMMENT This is an intriguing paper showing that abnormal upregulation of neuronal A2A receptors accelerates tau pathology and spatial memory impairment in a tau model. Of particular interest is the demonstration that an abnormal neuronal phenotype is able to ...
COMMENT This large study has better clarified both that there is indeed a behavioral variant of Alzheimer’s disease and that more anterior pathology underpins this variant. There are at least four variants of AD—the more typical amnestic variant, logopenic ...
COMMENT In this manuscript, “An atlas of cortical circular RNA expression demonstrates clinical and pathological associations with Alzheimer disease,” Dube et al. evaluated parietal RNA-Seq data from 13 control and 83 AD samples from Washington University and an ...
COMMENT Since LRRK2 plays a role in controlling the immune response of dendritic cells to Aspergillus, polymorphisms in this kinase could be responsible for a subpar immune response to fungi that permits CNS infection, leading to Parkinson's disease as the ...
