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Joshua Shulman on Tau, Speckle Wrecker, Disrupts the Nuclear Home

COMMENT This interesting work adds to a growing number of reports that tau can co-aggregate with RNA and RNA-binding proteins. Lester and colleagues further show that this leads to disruptions in nuclear compartments, such as speckles, that have critical roles in ...

Bess Frost on Tau, Speckle Wrecker, Disrupts the Nuclear Home

COMMENT This lovely study from the Parker lab further implicates tau as a splicing disruptor and identifies RNAs that are sequestered within tau aggregates (Raj et al., 2018; Apicco et al., 2019; Hsieh et al., 2019).  While the mechanistic aspect of the paper ...

Li-Huei Tsai on Does Synchronizing Brain Waves Bring Harmony?

COMMENT Many thanks for putting together such a comprehensive review of GENUS work reported at ADPD. I’d like to add that three additional groups have independently replicated our preclinical data on GENUS. Park et. al. sought to determine whether treadmill ...

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