7809 RESULTS
COMMENT Orexin and melatonin, the elephant in the room. The paper by Pappolla et al. brings attention to several important points regarding the mechanisms of amyloid accumulation: According to conventional concepts of cerebral interstitial fluid (ISF) clearance, ...
COMMENT We agree with previous commentaries emphasizing the limitations of the proposed framework for subject classification in research studies. Our main concern is the lack of reproducibility and consistency of subject classification when applying different ...
COMMENT Overall, the different Cell papers nicely document how nuclear import proteins function as chaperones: not only to transport disease-related RNA-binding proteins through the nuclear pore, but also to suppress unwanted liquid-liquid phase separations of ...
COMMENT Six new papers in Cell and Science on droplets in very different eukaryotic systems—from mammalian cells to fungi—and involved in different cellular mechanisms. What a week! These new works all point at the complexity of LLPS in living systems and show us ...
COMMENT Here are my thoughts on the paper. This screen is specifically trying to identify toxicity from two DPRs: PR and, to a lesser extent, GR. It does not speak to toxicity from other DPRs or from the repeats as RNA and it does not look at modifiers of RAN ...
COMMENT The paper from Wendeln and colleagues highlights the complexity of innate immune responses in the context of AD and demonstrates the ability of microglia to learn and modify their behavior in response to immunological stimuli. The authors’ work represents ...
COMMENT Wendeln and colleagues present an intriguing study that provides evidence for an innate immune memory in the brain. The expansion of the trained-immunity concept from the periphery to long-lived innate immune cells in the brain is a very promising step ...
COMMENT Essentially, systemic immune challenges have long been assumed to affect immune function in the brain. This interesting and thorough study formally demonstrates that such challenges can have lasting effects on microglia identity and function and, ...
COMMENT In Finland, we are widely using biomarkers of AD in clinical work, in particular MRI and CSF biomarkers. The new framework emphasizing the biomarkers irrespective of clinical symptoms in detecting AD early in research settings is very welcome. These are ...
COMMENT The new NIA-AA Framework for Alzheimer’s disease marks a big step forward in how we are looking at this disorder and will lead to better diagnostic principles. In addition, to base the diagnosis on pathobiology instead of clinical staging will help to ...
COMMENT This is a very interesting paper. The authors report increased Aβ deposition on PET scans in participants after one night of sleep deprivation. Aβ burden was increased in the right hippocampus and thalamus. I had a few observations and concerns about this ...
COMMENT This is an interesting study, presenting findings in line with our earlier work showing that a single night of sleep deprivation affects cerebrospinal fluid levels of Aβ (Ooms et al., 2014) and with recent work by Yu et al. (2017) indicating that slow ...
COMMENT I agree with the cautions by others that care must be taken not to let the new framework influence clinical practice until it is validated for that purpose. I’m sure that the authors will be the first to agree, but enforcing that might be difficult. The ...
COMMENT I absolutely agree that favourable genes (e.g not APOE4) could explain both the high cardiovascular fitness (healthy heart) and the decreased dementia risk (healthy brain). helena.horder_269141 0 ...
COMMENT This biomarker-based classification of AD should in my opinion not be promoted as an NIA-Alzheimer’s Association research policy recommendation, it should be considered a research proposal. I raise the concern that the proposed research scheme, published ...
