8396 RESULTS
COMMENT Drawing closer: Alzheimer’s blood test for primary care This study of Palmqvist et al. showed with fully automated immunoassays that the plasma Aβ1-42/Aβ1-40 ratio can predict amyloid plaque load (amyloidopathy) in the brain (BioFinder study). In addition ...
COMMENT I found this study particularly interesting because NfL in CSF (and probably in plasma) may be incorporated soon in clinical routine to the current biomarker panel. The strength of NfL is that, since it is only expressed in the nervous system, it can ...
COMMENT The story of the vascular effects of Aβ is evolving steadily, and the present paper, in conjunction with the paper of Cruz Hernández et al., 2019, represents the latest chapters. It has been known for a while that Aβ is a vasoconstrictor acting through ...
COMMENT Mouse models for Alzheimer’s disease only partially recapitulate the complexity of the human disease. Indeed, despite their aggressive amyloid pathology, current mouse models develop neither neurofibrillary tangles nor neuronal loss, both major hallmarks ...
COMMENT This study complements recent and past work showing that genetic background can significantly influence the onset, extent, and progression of amyloid-associated pathology in mouse models. To the best of my knowledge, this line of investigation started in ...
COMMENT This paper from Winer et al. provides a convincing contribution to the growing literature that objective and subjective measures of sleep are associated with Alzheimer’s disease pathology. In this case, lower amplitude of slow-wave activity (specifically ...
COMMENT I really liked how the authors used the regional data to ask whether amyloid had a local, global, or distant effect. The data convincingly confirm the absence of local toxicity of fibrillar Aβ, as detected using PET. It also shows that Aβ burden globally ...
COMMENT This is an interesting study that is trying to address an important apparent spatiotemporal paradox that arises when researchers try to reconcile large-scale spatial and temporal patterns associated with AD physiology and small-scale molecular events ...
COMMENT This is a very interesting paper. One of the intriguing features of AD is the anatomy of the human brain that is vulnerable. I believe that a reasonable consensus is that it involves the hippocampus and the default mode network, which has been ...
COMMENT What we’ve learned In this elegant study, Lloyd et al. show that a large number of pro-inflammatory microglia during acute demyelination undergo cell death in the form of necroptosis to give way to repopulating residual microglia with pro-remyelinating ...
COMMENT My comment will be primarily influenced by the structure of the Aβ 1-42 peptide DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (PDB 2MXU) and its mechanistic implications. The hydrophilic N-terminus is a relatively poorly organized region where antibodies ...
COMMENT It is exciting to read a paper focusing on potential mechanistic aspects of young plasma-mediated regeneration of the aging brain. In these elegantly designed studies, the focus lies on how synapse generation and synaptic function in human ES-cell-derived ...
COMMENT This paper provides a crucial window into the pathology of AD. The results appear to imply that tau is more directly related to cognitive decline than Aβ, and that developing therapeutics directed at abrogating tau might more likely to impede dementia ...
COMMENT I think the paper is very well performed and the results indicate that tau pathology is more closely related to cognitive decline than Aβ pathology. More importantly, the study indicates that it is the rate in increase in tau pathology (as measured with ...
COMMENT This JAMA Neurology paper by Hanseeuw et al. is a true tau-PET tour de force. With a sample of just 60 people who started with normal cognition and had seven years of follow-up data, the authors were able to provide some of the first in vivo longitudinal ...
