8069 RESULTS
COMMENT It is exciting to see the research community pursue anti-oligomer drug discovery and follow up on the original findings that LilrB2 is part of the oligomer receptor complex. It is a reflection of the renewed interest in the Aβ oligomer hypothesis and the ...
COMMENT In this paper, researchers led by Jiang and Eisenberg identified an Aβ oligomer binding site on the LilrB2 receptor, a noncanonical major histocompatibility complex class I immune receptor implicated in amyloid-mediated synaptotoxicity (Kim et al., 2013). ...
COMMENT The study is well-done, which is not surprising considering who did it. The authors are quite properly cautious about the long-term therapeutic implications since their molecule is a long way from being a drug; nevertheless, many projects have begun this ...
COMMENT We noted in a study by Geser et al., 2010, that pathological 43-kDa transactivation response DNA-binding protein (TDP-43) was present to a variable extent in the postmortem brains of 29 percent of longitudinally followed older (>age 65) schizophrenia ...
COMMENT I think this study is remarkable and credible. Our group has been interested in co-segregation of schizophrenia and other diseases in families. We surveyed DNA from our stored samples collected from patients with schizophrenia and found a handful with ...
COMMENT This is a fascinating finding which builds on the authors’ previous work highlighting the importance of an increase in the ratio of -synuclein monomers to tetramers as a key mechanism accelerating progressive changes. They show in these very careful ...
COMMENT This model, which recapitulates more cardinal features of PD than published PD models, supports the novel mechanistic insight that interfering with physiological α-synuclein tetramers can lead to PD. This mechanism is not widely recognized in the PD field ...
COMMENT This study by Silke Nuber, Ulf Dettmer, Dennis Selkoe and colleagues explores a key idea that they have championed—that α-syn normally exists as a multimer/tetramer, but abrogation of these physiologic conformations leads to an increase in monomers, ...
COMMENT I think that this is an extremely elegant study in which the authors rigorously assess the phenotype of transgenic mouse model in which the synuclein tetrameric form is destabilized. The phenotype seems more striking than observed in other mouse synuclein ...
COMMENT The mouse model presented by Nuber et al. is remarkable in that the patho-histology and the motor phenotypes closely resemble all the major hallmarks of Parkinson’s disease. Thus, it appears to be a good animal model for the disease. More broadly, their ...
COMMENT The observation by Elliot et al. that the Wnt-PCP pathway affects the processing of APP is original and interesting. However, we already published in 2015 that DKK1 increases the generation of amyloid-β by affecting the transcription of BACE1 (Parr et al. ...
COMMENT Classifying gene-expression patterns and their relationship to genetic variants is a very important way to determine proximate genetic mechanisms arising from genome-wide association studies (GWAS). The use of laser capture microdissection and RNA-seq is ...
COMMENT Several years after the discovery of the C9ORF72 repeat expansion as a major genetic cause of ALS/FTD, there is still a lot of controversy over its disease mechanisms, and the role that the formation of RNA foci and the accumulation of DPR proteins play ...
COMMENT Cholinergic Highlight: A comment by the Cholinergic System Working Group Co-authors and members of the CWG: H.Hampel, M. Mesulam, P. Snyder, A. Vergallo, G. Grossberg, M. Farlow, E. Giacobini, A. Levey, A. Nordberg, A. Khachaturian, and Z. Khachaturian. ...
COMMENT Several points have been made as to why this drug may have failed; however, here is one comment I have not seen made. Outcome measures such as the ADAS-COG, MMSE and ADCS-ADL, which are typically used in these trials, are broad measures of overall ...
