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331254 RESULTS

PAPER Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR Jr, Farlow MR, Hassenstab J, Jucker M, Morris JC, Xiong C, Karch CM, Levey AI, Gordon BA, Schofield PR, Salloway SP, Perrin RJ, McDade E, Levin J, Cruchaga C, Allegri RF, Fox NC, Goate A, Day GS, Koeppe R, Chui HC, Berman S, Mori H, Sanchez-Valle R, Lee JH, Rosa-Neto P, Ruthirakuhan M, Wu CY, Swardfager W, Benzinger TL, Sohrabi HR, Martins RN, Bateman RJ, Johnson KA, Sperling RA, Greenberg SM, Schultz AP, Chhatwal JP, Dominantly Inherited Alzheimer Network and the Alzheimer’s Disease Neuroimaging Initiative

Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease.

JAMA Neurol. 2023 Dec 1;80(12):1353-1363. PubMed: 37843849

PSEN1 F176V

MUTATIONS PSEN1 73653606 GRCh37/hg19 T G Exon 6 Coding Increased the Aβ42/Aβ40 ratio and decreased the Aβ (37 + 38 + 40) / (42 + 43) ratio. Atrophy of the hippocampus, parahippocampal cortex, and head of the caudate nucleus. Aβ plaques, tau-immunopositive neurons,

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