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Amy Pooler on Could Sumoylation Take Down Tangles?

COMMENT It’s been almost a decade since the exciting initial discovery of tau SUMOylation by SUMO1, which inhibits degradation of tau and promotes its accumulation. However, it is unknown whether other SUMO isoforms have a similar role. Perhaps surprisingly, thes

Could Sumoylation Take Down Tangles?

CONFERENCE COVERAGE 2024-04-12 Conference Coverage Scientists are expanding strategies for targeting misfolded tau. At this year’s AD/PD conference, held March 5 to 9 in Lisbon, Portugal, speakers highlighted a protein modification approach—sumoylation. This post-translational modifica

PAPER Stige KE, Kverneng SU, Sharma S, Skeie GO, Sheard E, Søgnen M, Geijerstam SA, Vetås T, Wahlvåg AG, Berven H, Buch S, Reese D, Babiker D, Mahdi Y, Wade T, Miranda GP, Ganguly J, Tamilselvam YK, Chai JR, Bansal S, Aur D, Soltani S, Adams S, Dölle C, Dick F, Berntsen EM, Grüner R, Brekke N, Riemer F, Goa PE, Haugarvoll K, Haacke EM, Jog M, Tzoulis C

The STRAT-PARK cohort: a personalized initiative to stratify Parkinson's disease.

Prog Neurobiol. 2024 Apr 9;:102603. PubMed: 38604582

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