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PAPER Gunawan C, Fleming C, Irga PJ, Jien Wong R, Amal R, Torpy FR, Mojtaba Golzan S, McGrath KC
Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer's disease.
Environ Int. 2024 Mar;185:108512. Epub 2024 Feb 23 PubMed: 38412566PAPER Shi T, Shen S, Shi Y, Wang Q, Zhang G, Lin J, Chen J, Bai F, Zhang L, Wang Y, Gong W, Shao X, Chen G, Yan W, Chen X, Ma Y, Zheng L, Qin J, Lu K, Liu N, Xu Y, Shi YS, Jiang Q, Guo B
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression.
Nat Metab. 2024 Mar;6(3):531-549. Epub 2024 Feb 26 PubMed: 38409606Hyouna Yoo
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Debomoy Lahiri, Bryan Maloney on Epigenetic Shenanigans—In AD, Chromatin Opens Up in Blood Immune Cells
COMMENT We read the this paper (Ramakrishnan et al., 2024) with great interest and agree with others’ comments already posted in Alzforum. We have long maintained that there is an important role for epigenetic markers in the etiology of AD (Maloney and Lahiri, 20
PAPER Galea I, Bechmann I, Perry VH
What is immune privilege (not)?
Trends Immunol. 2007 Jan;28(1):12-8. Epub 2006 Nov 28 PubMed: 17129764Chiara Cirelli on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This is a beautiful study with compelling results. That the authors discovered a role for glia in protecting neurons from wake-related oxidative stress is quite unexpected and eye-opening. The next step will be to test the extent to which this mechanism a
Erik Musiek on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This is an exciting finding. It builds on work from Hugo Bellen’s lab, which showed that astrocytes can take up lipid droplets from stressed/injured neurons as a neuroprotective mechanism. This new paper provides a novel connection to sleep deprivation, w
Sarah Cohen on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This exciting new paper from the Seghal lab makes an unexpected connection between reactive oxygen species (ROS), lipid metabolism, and sleep. Previous work had shown that neurons release ROS-damaged peroxidated lipids when overexcited or stressed; these
Russell Swerdlow on While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
COMMENT This is a fantastic study. It addresses fundamental issues of brain bioenergetic metabolism that relate and link to several AD-relevant phenomena, including neuron-glia interplay, apolipoprotein E biology, lipid metabolism, oxidative stress, circadian rhy
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain
RESEARCH NEWS 2024-02-27 Research News How does a good night’s sleep re-energize the brain? At least in fruit flies, by burning damaged lipids. So claim scientists led by Amita Sehgal at the University of Pennsylvania in Philadelphia. In the February 15 Nature Neuroscience, they
PAPER Yang Z, Wu Y, Liu H, He L, Deng X
AMYGNN: A Graph Convolutional Neural Network-Based Approach for Predicting Amyloid Formation from Polypeptides.
J Chem Inf Model. 2024 Mar 11;64(5):1751-1762. Epub 2024 Feb 26 PubMed: 38408296Current Filters
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