Interventions to Reduce Sleep Health Disparities (R01- Clinical Trials Optional) (PAR-24-110)

GRANT Friday, April 19, 2024- 3:30pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-110.html 08 Sep 2027

Tau Toggling Peptides: One Seeds Fibrils; the Other Dismantles Them

RESEARCH NEWS 2024-04-19 Research News The accumulation of neurofibrillary tangles is the common thread among all tauopathies, yet each amasses fibrils with a distinct fold at their core. What forces goad tau into twisting into these specific folds in the first place, and once fi

PAPER Ponia SS, Robertson SJ, McNally KL, Subramanian G, Sturdevant GL, Lewis M, Jessop F, Kendall C, Gallegos D, Hay A, Schwartz C, Rosenke R, Saturday G, Bosio CM, Martens C, Best SM

Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.

Cell Rep. 2021 Oct 26;37(4):109888. PubMed: 34706234

PAPER Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, Tscherter A, Kitada T, Bonsi P, Shen J, Pisani A

Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.

Exp Neurol. 2009 Feb;215(2):388-96. Epub 2008 Nov 21 PubMed: 19071114

PAPER Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, Kress A, Nicolas AM, Mohs K, Becker C, Neurath MF, Farin HF, Buchholz CJ, Andreux PA, Rinsch C, Greten FR

Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy.

Immunity. 2022 Nov 8;55(11):2059-2073.e8. Epub 2022 Oct 19 PubMed: 36351375

PAPER Cairns G, Thumiah-Mootoo M, Abbasi MR, Racine J, Lariovov N, Prola A, Khacho M, Burelle Y

PINK1 Deficiency Alters Muscle Stem Cell Fate Decision And Muscle Regenerative Capacity.

bioRxiv2023.06.23.546123

PAPER Mu J, Zhang D, Tian Y, Xie Z, Zou MH

BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo.

J Mol Cell Cardiol. 2020 Dec;149:1-14. Epub 2020 Sep 15 PubMed: 32941882

PAPER Li J, Dang X, Franco A, Dorn GW 2nd

Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events.

Front Cell Dev Biol. 2022;10:868465. Epub 2022 May 12 PubMed: 35646911

PAPER Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak TW

PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9572-7. Epub 2011 May 23 PubMed: 21606348

PAPER Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, Stefani A, Shen J, Pisani A, Bonsi P

Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease.

Neuroscience. 2011 Mar 17;177:240-51. Epub 2010 Dec 31 PubMed: 21195752

PAPER Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YX, Lutter L, Boyer DR, Cheng X, Pi J, Zhang J, Lu J, Yang S, Yu Z, Feigon J, Eisenberg DS

How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimers disease brain by a strain-relief mechanism

bioRxiv2024.03.25.586668

Keystone Symposium- Drug Delivery to the Brain: Emerging Modalities

CONFERENCE 2025-02-17 00:00:00-2025-02-20 00:00:00 Keystone, Colorado 17 &#x2013 20 February 2025 View Conference Website 0

Rubbing Microglia the Right Way? At ADPD, Scientists Showcase New Strategies

CONFERENCE COVERAGE 2024-04-19 Conference Coverage Microglia seem to play a hand in every aspect of Alzheimer’s pathogenesis, from the seeding and clearing of plaques to the traveling of tau to the dying of neurons. Scientists are pursuing therapeutics that both promote their neuroprot

Sarmad Peymaei

University of Bern
Bern, Switzerland

PAPER Liao JZ, Chung HL, Shih C, Wong KK, Dutta D, Nil Z, Burns CG, Kanca O, Park YJ, Zuo Z, Marcogliese PC, Sew K, Bellen HJ, Verheyen EM

Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila.

Nat Commun. 2024 Apr 18;15(1):3326. PubMed: 38637532