INTERVIEWS 2004-03-15 Interviews Sheldon Goldberg In 2002, Sheldon Goldberg assumed the top job at the (Alzheimer's Association) after 30 years in national associations and long-term care management (See bio [.pdf]). Prior to becoming president and CEO of the associatio
RESEARCH NEWS 2004-03-15 Research News A multi-institutional collaboration led by Sam Gandy at Thomas Jefferson University, Philadelphia, has vaccinated rhesus monkeys (Macaca mulatta) against the Aβ peptide in an effort to establish a more human-like animal model than mice for u
RESEARCH NEWS 2004-03-14 Research News Researchers who follow the ups and downs of protein expression in Alzheimer’s disease (AD) may well think they are being taken on a roller coaster ride. Early on, many proteins are upregulated, and at later stages, they become downregulated.
RESEARCH NEWS 2004-03-14 Research News A report in press in the Journal of Biological Chemistry, published online February 24, adds to the growing body of evidence that traces the etiology of Parkinson's disease to the mitochondria. Jie Shen and colleagues at Brigham and Wom
INTERVIEWS 2004-03-08 Interviews William A. Haseltine Note: On March 25, Haseltine announced that he will retire from Human Genome Sciences later this year. He will continue his not-for-profit work, some of which he discussed below. As founder, Chairman, and CEO of the biote
RESEARCH NEWS 2004-03-08 Research News In the current Archives of General Psychiatry, George Uhl and Robert Grow from the National Institutes of Health compile an overview of the known genetic components of major brain diseases and then apportion the cost to society accordingly.
RESEARCH NEWS 2004-03-05 Research News In this week’s PNAS, Fernando Nottebohm and colleagues at Rockefeller University, New York, report that brain-derived neurotrophic factor (BDNF) protects newborn neurons in songbirds. BDNF has also been linked to long-term potentiation, memo
RESEARCH NEWS 2004-03-04 Research News The triplet repeat disease X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a polyglutamine expansion in the androgen receptor (AR) gene. Just how this expansion causes degeneration of lower motor neurons is unclear, but in to
RESEARCH NEWS 2004-03-04 Research News PAR-1, a homologue of microtubule-affinity regulating kinase (MARK), kicks off the phosphorylation events that culminate in cell death in a fly model of tauopathy, according to a report in today’s issue of Cell by Bingwei Lu and colleagues.
RESEARCH NEWS 2004-03-02 Research News DNA makes RNA makes protein. That's how the dogma goes. But it doesn't always work out that way. In a minority of cases the DNA code is actually rewritten through RNA editing. In the February 26 Nature, Shin Kwak and colleagues at
RESEARCH NEWS 2004-03-01 Research News Where there is more BACE, there is more Aβ. In the current online Early Edition of PNAS, Rena Li, Yong Shen, and their collaborators at Sun Health Research Institute in Sun City, Arizona, show that increased BACE expression and activity corr
RESEARCH NEWS 2004-03-01 Research News Amyloidoses are a varied and complex set of syndromes caused by aggregation of specific proteins such as the amyloid-β, found in the brains of Alzheimer's patients, and transthyretin, which is found in a variety tissues damaged by syste
RESEARCH NEWS 2004-03-01 Research News As drug discovery in AD research is shifting from inhibiting the γ-secretase to inhibiting the β-secretase (BACE), interest in the entire life cycle of BACE has grown, concomitantly. In the current online Early Edition of PNAS, Vincent Mauro
RESEARCH NEWS 2004-02-20 Research News The Reuters news agency reported today that Eli Lilly and Co. has notified doctors of a significant increase in the risk for stroke and death that it has observed in demented elderly patients who take its drug Zyprexa. This antipsychotic is