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Curry Ingredient Spices Things Up by Blocking Aβ Aggregation

RESEARCH NEWS 2004-12-20 Research News The curry spice curcumin is a potent antioxidant and has been investigated by Greg Cole's team at the University of California, Los Angeles, for possible protective roles in Alzheimer disease inflammatory processes (see ARF related news

Cementing γ-Secretase at the Cell Surface

RESEARCH NEWS 2004-12-18 Research News In an article published online 29 November 2004 in the Journal of Biological Chemistry, Dennis Selkoe's team reports further evidence placing the mature γ-secretase complex at the cell surface, and implicating it in cleavage of amyloid-

Two Other Faces of Inflammation—Stem Cell Guidance and Axon Repair

RESEARCH NEWS 2004-12-16 Research News If you have an accident, calling 911, or your local equivalent, will get you the paramedics. In case of neural injury, dialing up SDF-1 might get you a dose of much-needed stem cells, while class 1 MHC molecules might be just what you need t

Linking Leptin to AD

RESEARCH NEWS 2004-12-15 Research News Though there is already plenty of evidence linking lipid metabolism and obesity to Alzheimer disease (AD) and other neurodegenerative diseases (see, for example, ARF related news story and ARF news story), the case just got stronger. Reporti

Controlling Huntingtin with Chaperones and Intrabodies

RESEARCH NEWS 2004-12-13 Research News The link between protein aggregation and neurodegenerative diseases is certainly a hot topic these days, awash with questions over whether reducing aggregation is a good idea, and if it is, what aggregates should be targeted. Perhaps just th

Parkinson Therapies Go Deep and Shallow

RESEARCH NEWS 2004-12-08 Research News Two articles from the past week describe very different approaches to therapy for Parkinson disease (PD). A paper published 2 December in PNAS went close to the root of the problem, reporting that overexpression of parkin from cDNA delivered

Enabling Technologies 2004 Workshop Summary

CONFERENCE COVERAGE 2004-12-05 Conference Coverage This report summarizes discussions and recommendations made at the fourth annual workshop on Enabling Technologies for Alzheimer's disease (AD), held in August 2004 in Bar Harbor, Maine. Academic and industry scientists from insid

Major Points of Discussion and Ideas for Future Directions

CONFERENCE COVERAGE 2004-12-05 Conference Coverage Axonal Transport Larry Goldstein, of University of California, San Diego, laid out his hypothesis that defects in axonal transport could starve the nerve terminal of needed supplies and lead to synaptic dysfunction in AD, Huntington�

List of Final Recommendations from Bar Harbor

CONFERENCE COVERAGE 2004-12-05 Conference Coverage List of Final Recommendations 1. Make better mouse models. Create strains with only subtle overexpression under endogenous promoter and authentic spatiotemporal regulation, such as YAC. Recreate humanized APP rat unavailable from Cepha

Sharpen Your Synapses with Rolipram!

RESEARCH NEWS 2004-12-03 Research News Among its many reputed transgressions, amyloid-β is suspected of interfering with synaptic function from the earliest stages of Alzheimer disease (see ARF related news story). A study published in the December issue of the Journal of Clinica

GSK-3—A Peripheral Marker for AD?

RESEARCH NEWS 2004-12-02 Research News Different isoforms of glycogen synthase kinase-3 (GSK-3) have been linked to Alzheimer disease (AD). The β variant is one of several kinases that phosphorylate the microtubule-associated protein tau (see ARF related news story), which, when

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