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Similar Risk Factors Found for Young- and Late-Onset Dementia

RESEARCH NEWS 2024-01-05 Research News Health and lifestyle influence the risk of late-onset dementia. Is this true when disease begins before age 65? Yes, according to researchers led by Stevie Hendriks and Sebastian Köhler, Maastricht University, the Netherlands. In the Decembe

Heart Failure Drug Drastically Skews Blood Aβ

RESEARCH NEWS 2023-12-28 Research News Anyone on the heart failure drug Entresto who tests positive for Alzheimer’s disease based on blood Aβ42/40 might not want to panic. That’s because the drug can lower the amyloid ratio three times more than does brain amyloidosis. This is ac

Alzheimer’s Microglial Risk Gene INPP5D Revs Up Inflammasome

RESEARCH NEWS 2023-12-27 Research News Although researchers know that most of the genetic risk for late-onset Alzheimer’s disease resides in microglia, exactly how these genes work their mischief remains something of a black box. In the November 29 Nature Communications, research

Plaques Kick Neocortical Neurons into Overdrive, Entangling Tau

RESEARCH NEWS 2023-12-26 Research News Aggregation of Aβ throughout the neocortex is widely believed to unleash neurofibrillary tangles in the medial temporal lobe in people with AD. But what connects these two infamous proteopathic culprits in different regions of the brain? A s

New Atlas Charts Mouse Brain in Exquisite Detail

RESEARCH NEWS 2023-12-22 Research News The picture of the mouse brain just got exponentially more complex. Using single-cell transcriptomics, epigenomics, and spatial genomics, scientists created an atlas of 32 million brain cells across all regions, distinguishing 5,300 cell typ

‘Slide-tags’ Method Sharpens Spatial Transcriptomics

RESEARCH NEWS 2023-12-21 Research News Spatial transcriptomics may have just achieved single-cell resolution. Researchers led by Evan Macosko, Fei Chen, and colleagues at the Broad Institute in Cambridge, Massachusetts, bound together spatial gene expression and single-cell trans

At Holloway Summit, FTD Imaging Shows New Vista

CONFERENCE COVERAGE 2023-12-19 Conference Coverage At the second annual Holloway Summit, held November 30 to December 1 in Miami, frontotemporal dementia researchers showcased the current state of knowledge in finding biomarkers that identify different underlying pathologies of the dis

Second Holloway Summit Showcases Intense Search for FTD Biomarkers

CONFERENCE COVERAGE 2023-12-19 Conference Coverage Because frontotemporal dementia is a rare disease, it has not gotten nearly the attention or research dollars of its big cousin, Alzheimer’s. As a result, progress in the field has lagged behind, particularly with regard to biomarkers.

APOE Christchurch Variant Tames Tangles and Gliosis in Mice

RESEARCH NEWS 2023-12-17 Research News The astonishing case of Aliria Rosa Piedrahita de Villegas captivated scientists because she was spared the wrath of her Paisa presenilin 1 mutation. She staved off dementia for three decades longer than her kin and had few neurofibrillary t

Can Organ Aging Clock Foretell Cognitive Decline?

RESEARCH NEWS 2023-12-14 Research News A person’s body does not age uniformly; instead, some parts wear out before others. A new study in the December 6 Nature online now puts numbers to this, and pins down the proteins involved. Researchers led by Tony Wyss-Coray at Stanford Uni

Sought FUS, Found TAF—A New Fibril in Frontotemporal Dementia

RESEARCH NEWS 2023-12-14 Research News While filaments of either tau or TDP-43 underlie 90 percent of frontotemporal dementia cases, the proteopathic culprits behind the remaining 10 percent have eluded researchers. Fused in sarcoma (FUS) often forms inclusions in such cases, hen

Are T Cells to Blame for Cognitive Impairment Caused by Hypertension?

RESEARCH NEWS 2023-12-11 Research News Hypertension has long been linked to cognitive impairment, but physical strain on small blood vessels in the brain might not be the only explanation. In the December 4 Nature Neuroscience, scientists led by Monica Santisteban and Costantino

Transient Filament Yields AD and CTE Tau Fibrils

RESEARCH NEWS 2023-12-08 Research News Akin to erratic teenagers, tau may try dozens of amyloid filament styles before settling into the stable configurations found in the brains of people with AD or other tauopathies. This is according to a study published November 29 in Nature,

And Then There Were Five: CSF Proteomics Defines Alzheimer’s Subtypes

RESEARCH NEWS 2023-12-07 Research News Proteins floating in the cerebrospinal fluid might do more than diagnose Alzheimer’s disease—they may identify different subtypes, according to researchers led by Betty Tijms of the Amsterdam University Medical Center and Pieter Jelle Visser

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