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RESEARCH MODELS Overview This knock-in (KI) mouse model was generated by introducing a R1441C missense mutation into the GTPase domain at exon 31 of the mouse Lrrk2 (leucine-rich repeat kinase 2) gene (Tong et al., 2009). As such, this mutation is expressed through the c
RESEARCH MODELS Summary MAPT 10IVS+16 C>T mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are
RESEARCH MODELS Summary MAPT(H1.0)-GR mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are precise
RESEARCH MODELS The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare missense variant in this gene, P522R, has been associated with reduced risks of Alzheimer’s disease
RESEARCH MODELS Summary The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare missense variant in this gene, P522R, has been associated with reduced risks of Alzheimer’s
RESEARCH MODELS A528T is a common variant of SORL1 that has been shown to associate with a slightly increased risk of AD (~15 percent) in people of European ancestry and to segregate with disease in some families. CRISPR/Cas9 gene editing was used to introduce the A528T
RESEARCH MODELS The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare missense variant in this gene, P522R, has been associated with reduced risks of Alzheimer’s disease
RESEARCH MODELS The PLCG2 gene encodes the enzyme phospholipase C gamma 2 (PLCγ2), a mediator of transmembrane signaling in microglia that acts downstream of TREM2. A rare missense variant in this gene, rs72824905 (P522R), is associated with a reduced risk of Alzheimer’s
RESEARCH MODELS Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor that modulates microglial activity and survival. A rare variant in TREM2, R47H, triples the risk of Alzheimer’s disease in heterozygous carriers. This knock-in model carr
RESEARCH MODELS Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is a transmembrane receptor that modulates microglial activity and survival. A rare variant in TREM2, R47H, triples the risk of Alzheimer’s disease in heterozygous carriers. This knock-in model carr
RESEARCH MODELS Summary This unique model provides scientists the opportunity to study the effects of Aβ dimers independent of amyloid plaques, Aβ monomers, or other Aβ oligomers. The TgDimer mouse carries a transgene encoding the 751-amino-acid isoform of human APP with
RESEARCH MODELS Summary This rat line, created using CRISPR/Cas9 technology, carries a humanized Aβ sequence and three Alzheimer’s-linked mutations (Swedish, KM670/671NL; Arctic, E693G; and Iberian, I716F) in the endogenous rat App gene (Pang et al., 2022). Knock-in rat
RESEARCH MODELS This mouse model enables Cre-inducible overexpression of human SORL1. A transgene containing SORL1 cDNA downstream of the cytomegalovirus early enhancer/chicken β-actin promoter and a floxed neomycin resistance cassette with a polyA stop element (neo-R) w
RESEARCH MODELS In this model of SORLA deficiency, the 5' region of exon 4 of the murine Sorl1 gene was replaced by a neomycin resistance cassette. Although mice homozygous for the disrupted allele do not make full-length SORLA protein (Andersen et al., 2005), an in
RESEARCH MODELS Summary MAPT(H2.1)-GR mice are among a series of models developed by Michael Koob and colleagues at the University of Minnesota, collectively referred to as Gene Replacement – Alzheimer’s Disease (GR-AD) mice. In GR-AD mice, “genes of interest are precise
