1381 RESULTS
CONFERENCE COVERAGE 2005-04-01 Conference Coverage When most people think of Alzheimer disease (AD), they imagine parenchymal amyloid plaques. But vascular deposits can be just as damaging. Consider familial dementias caused by the Dutch (E693Q) or Iowa (D694N) mutations in AβPP (see r
CONFERENCE COVERAGE 2005-04-01 Conference Coverage March 14, the day after the AD/PD conference drew to a close in Sorrento, a meeting on Molecular Mechanisms of Neurodegeneration kicked off at University College Dublin, Ireland. Given that this island nation gets a bum rap for its sup
CONFERENCE COVERAGE 2005-03-31 Conference Coverage Exactly what makes p25/Cdk5 so deadly to neurons? A good place to start tracing the path of this rogue kinase would be retinoblastoma (Rb), a tumor suppressor protein positioned strategically at the crossroads between cell proliferatio
CONFERENCE COVERAGE 2005-03-28 Conference Coverage No, this is not a story, published in the wrong place, about a misbehaving sports star. It is about protein growth factors in Alzheimer disease. Apparently, the pro-form of nerve growth factor is an obnoxious player in early AD, wherea
CONFERENCE COVERAGE 2005-03-24 Conference Coverage With the myriad of different techniques that are now available to visualize changes in the brain, neuroimaging seems poised to make a real difference for people with neurodegenerative diseases. But at this point, it is well-nigh imposs
CONFERENCE COVERAGE 2005-03-24 Conference Coverage Not only the sweet scent from the ubiquitous citrus trees aroused the senses at the 7th international AD/PD meeting in Sorrento, but the unlikely theme of ectodomains managed to do so, too. And while gravity’s role in shedding ripe fru
CONFERENCE COVERAGE 2005-03-23 Conference Coverage With heart disease, high cholesterol levels prompt the doctor to prescribe statins and urge other preventive measures. A suspicious PSA screens warns the doctor that an aging prostate is misbehaving. Why is such a laboratory test not a
CONFERENCE COVERAGE 2005-03-23 Conference Coverage This is part 2 of the biomarker update from Sorrento. Picture Power Besides biochemistry and genetics, the search for early markers has focused heavily on brain imaging. Pittsburgh Compound-B (PIB) has broken new ground by lightening u
CONFERENCE COVERAGE 2005-03-18 Conference Coverage If you need a reason to get off the bench and work up a sweat, consider this: Increasing physical and mental activity dramatically lowers amyloid plaque deposition in a mouse model of Alzheimer's disease, according to a study pres
CONFERENCE COVERAGE 2005-03-17 Conference Coverage One of the surprises at the AD/PD 2005 conference held last week in Sorrento, Italy, lay in just how many groups presented new experimental therapy approaches in various stages of preclinical development. This welcome news accompanies
CONFERENCE COVERAGE 2005-03-17 Conference Coverage Spooked by the pitfalls of γ-secretase drug development (see companion Sorrento story), BACE fans like to point out that their aspartyl protease may be a safer target. They take comfort in pointing out that compared to γ-secretase knoc
CONFERENCE COVERAGE 2005-03-15 Conference Coverage Yesterday, the 7th International Conference on Alzheimer’s and Parkinson’s disease—AD/PD 2005 for short—drew to a close in beautiful Sorrento, Italy. Nearly 1,500 scientists from 52 countries met to brush up on news and trends in resea
CONFERENCE COVERAGE 2005-01-29 Conference Coverage Summary by Peter Davies, Albert Einstein College of Medicine. The first thing to note is that we really underestimated the popularity of the topic. We invited only about 100 people, but by the end of the day, there were more than twice
CONFERENCE COVERAGE 2004-12-20 Conference Coverage Speakers include: Randolph Hampton Paul Muchowski Ana Maria Cuervo Ralph Nixon Cynthia McMurray Randolph Hampton of University of California, San Diego, introduced the audience to his lab’s work on quality control pathways, which serve
CONFERENCE COVERAGE 2004-12-17 Conference Coverage Speakers include: Harald Janovjak Eckhard Mandelkow Judith Frydman James Bowie Charlie Glabe See the movie What new techniques have come on line to study protein misfolding? Harald Janovjak introduced the audience to the latest refinem
