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Intraneuronal Aβ: Was It APP All Along?

WEBINAR 2011-06-20 On 16 June 2011, ARF held a Webinar with Eddie Lee, Todd Golde, Gunnar Gouras, Frank LaFerla, Virginia Lee, Lars Nilsson, and Robert Vassar to discuss this study’s implications for intraneuronal Aβ and its role in AD pathogenesis. The Guest Moderator was ...

Two New Sets of Diagnostic Criteria—Which Is Right for Your Clinic?

WEBINAR 2011-06-16 On 19 April 2011, the National Institute on Aging (NIA) and the Alzheimer’s Association (AA) published new guidelines for the diagnosis of Alzheimer’s disease (AD) and its pre-dementia and preclinical phases (see ARF related news story on McKhann et al., ...

Volunteers Help Scientists Explore Down’s, Alzheimer’s Nexus

WEBINAR 2011-06-01 Children born with Down’s syndrome can receive excellent healthcare at specialized clinics, but once they become adults, their care often falls to doctors who may be less qualified to deal with their specific needs. The new Down Syndrome Center for ...

Grasping the Shadow Force: Immune Cells in ALS

WEBINAR 2011-05-12 When two biological networks as complex as the nervous and immune systems cross paths, you know the interaction is not going to be simple. Add in neurodegeneration—such as amyotrophic lateral sclerosis—and it creates a web that will take many scientists ...

Reimagining Alzheimer's Disease—Time for Bright New Ideas?

WEBINAR 2011-05-03 Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger ...

Herpes Simplex and Alzheimer’s—Time to Think Again?

WEBINAR 2011-04-15 On Thursday, 24 February 2011, Ruth Itzhaki, University of Manchester, U.K.; Elisa Porcellini, University of Bologna, Italy; Luc Letenneur, INSERM, Bordeaux, France, and Richard Smeyne, St. Jude Children’s Research Hospital, Memphis, Tennessee, shared ...

Stress Granules and Neurodegenerative Disease—What’s the Scoop?

WEBINAR 2011-02-17 The formation of cytoplasmic inclusions called stress granules is one of nature’s many ways of coping with adverse situations. It appears that these inclusions sequester non-essential messenger RNAs, allowing cells to focus on making proteins, such as ...

Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)

WEBINAR 2010-12-22 This Webinar recapped the latest research in this area. Michael Heneka of the University of Bonn, Germany, and Doug Feinstein of the University of Illinois, Chicago, gave presentations, and were joined in a panel discussion by Virgil Muresan, New Jersey ...

The AD8—Dementia Screen Ready for Prime Time?

WEBINAR 2010-12-02 Have you been waiting for a quick yet reliable test for early dementia? The AD8 might be your answer. The interview-based screening tool detects early cognitive impairment, has been validated against the clinical dementia rating scale and against ...

Untapped Resource? New Study to Boost Acceptance of CSF Analysis

WEBINAR 2010-09-20 Cerebrospinal fluid (CSF) analysis has perhaps the strongest diagnostic and prognostic potential for Alzheimer disease to date, yet some think the field is not harnessing its full power because patients, doctors, and even some investigators harbor ...

Microdissection and Microarrays: Analyzing Selective Cell Vulnerability

WEBINAR 2010-09-16 As Tolstoy wrote in Anna Karenina, “Happy families are all alike; every unhappy family is unhappy in its own way.” The same might be said of the brain. Normal brains look and behave similarly, but those affected by different neurodegenerative diseases are ...

Together at Last, Top Five Biomarkers Model Stages of AD

WEBINAR 2010-07-29 In this Webinar, Clifford Jack gave a slide talk summarizing a staged biomarker model of the Alzheimer’s cascade, followed by a panel discussion with Chet Mathis, David Holtzman, Henrik Zetterberg, Paul Aisen, Keith Johnson, Giovanni Frisoni, Douglas ...

New Models for Integrative Care of Alzheimer Disease

WEBINAR 2010-06-25 On 25 June 2010, Ken Kosik, M.D., a neuroscientist at the University of California, Santa Barbara (UCSB), and the executive director of Cognitive Fitness and Innovative Therapies (CFIT), led a Webinar about CFIT, which he describes as "the first full ...

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