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RESEARCH NEWS 2019-04-12 Research News Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) stave off dementia, but multiple clinical trials have failed to bear that out. Now, the most recent and, the authors say, final effort has come up short. In the
RESEARCH NEWS 2019-07-26 Research News The 2015 discovery of lymphatic vessels in the brain’s meninges threw open a door to seeing how this still-mysterious organ clears waste. Subsequent work showed that these vessels, which reside in the brain’s outermost membrane, the dura mat
RESEARCH NEWS 2020-02-06 Research News Like Aβ oligomers, soluble aggregates of tau and α-synuclein bind to cellular prion protein, poisoning neurons, according to a study published in Acta Neuropathologica. Using a standardized procedure to produce soluble aggregates of these th
RESEARCH NEWS 2020-10-16 Research News The exquisite specificity of antibodies powers neurodegenerative research, enabling reliable assays, precise diagnostics, and targeted therapeutics. Unless … some antibodies are not as specific as has been thought. In the September 22 Neurob
CONFERENCE COVERAGE 2021-08-06 Conference Coverage The FDA’s controversial approval of aducanumab hinged on the premise that clearance of amyloid would be “reasonably likely” to bestow a cognitive benefit. Data presented at the Alzheimer’s Association International Conference (AAIC), h
RESEARCH NEWS 2021-10-06 Research News After decades of nonstarters, blood tests for Alzheimer’s disease are finally here, enabling researchers to predict who may have amyloid plaques in their brain. Among the candidate tests jostling for attention, are some better than others? R
RESEARCH NEWS 2022-03-18 Research News Echoing the past phase of irreproducible genetic association studies, an inability to replicate relationships between brain structure, function, and behavior besets brain imaging researchers today. How can they up their game to be sure brain
RESEARCH NEWS 2021-11-08 Research News People with Alzheimer’s disease have trouble sleeping and awaken frequently, but exactly why this happens is unclear. In the November 3 Science Translational Medicine, researchers led by Jeannie Chin, Baylor College of Medicine, Houston, hom
CONFERENCE COVERAGE 2022-08-26 Conference Coverage Consensus is strengthening among Alzheimer’s researchers that antibodies that abolish plaque nudge down the rate of cognitive decline. Alas, the effect is so small—is it meaningful? At the Alzheimer’s Association International Conferen
RESEARCH NEWS 2021-04-21 Research News Could it be that microglia build plaques rather than bust them? In the April 15 Nature Immunology, researchers led by Greg Lemke at the Salk Institute for Biological Studies, La Jolla, California, add to the evidence for this idea. In a mous
RESEARCH NEWS 2023-06-02 Research News Why do some people with amyloid plaques decline, while others do not? In the May 29 Nature Medicine, researchers led by Tharick Pascoal at the University of Pittsburgh laid some of the blame on reactive astrocytes. Among cognitively healthy
COMMUNITY NEWS 2023-06-16 Community News The Alzheimer’s community lost another notable member with the May 5 passing of Donald Price of Johns Hopkins University, Baltimore, at the age of 87. Price’s work on the cholinergic system was instrumental in the development of cholinester
RESEARCH NEWS 2021-01-22 Research News The virus–Alzheimer’s tug of war continues. New data across several studies weaken the proposed, and much-debated, association; its proponents are holding fast. A new epidemiology study reports a weak link between herpes and dementia. Resear
RESEARCH NEWS 2024-02-09 Research News Cerebrospinal fluid washes waste from the brain, eventually draining into the lymph nodes and bloodstream—but exactly how this flow bypasses the brain’s barriers to reach the periphery has remained somewhat mysterious. In the February 7 Natu
RESEARCH NEWS 2023-02-03 Research News Could a biomarker for TDP-43 pathology be on the horizon? This RNA/DNA-binding protein accumulates in nearly all people with amyotrophic lateral sclerosis, and almost half of those with frontotemporal dementia, but can only be detected at au
