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Keystone: Death Receptor Ligand—New Role for APP, New Model for AD?

CONFERENCE COVERAGE 2009-02-20 Conference Coverage At the Keystone Symposium, Neurodegenerative Diseases: New Molecular Mechanisms on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session. Marc Tessier-Lavigne, Genentech Inc., San ...

Genetic Testing a Foggy Crystal Ball at Best?

RESEARCH NEWS 2012-04-04 Research News Sequencing a person’s entire genome will foretell many diseases only marginally better than gazing into a crystal ball, according to a report in the April 2 Science Translational Medicine online. Researchers at Johns Hopkins University in ...

CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate

CONFERENCE COVERAGE 2012-11-09 Conference Coverage Held 29-31 October in the Principality of Monaco, the 5th Clinical Trials in Alzheimer’s Disease conference offered new data from ongoing analyses of the Phase 3 programs on solanezumab and bapineuzumab. Both programs missed their ...

Early Intervention Trial Bears Little Fruit, but Sows Hope

RESEARCH NEWS 2005-04-15 Research News Is the glass half empty or half full? Alzheimer disease (AD) clinicians might be asking themselves that question after seeing the long-awaited results of a large, prospective clinical study weighing the ability of vitamin E or the ...

Cholinergic Transmission and Aβ: Boosting M1 Receptors Treats Model

RESEARCH NEWS 2006-03-03 Research News An impressive data set that appeared yesterday in Neuron shows that a specific M1 muscarinic receptor agonist can reverse both cognitive deficits as well as the amyloid and tau pathology in the APP/PS1/tau triple transgenic mice mouse model ...

Coping with Copper—Minute Amount of Metal Plagues Rabbit Brain

RESEARCH NEWS 2003-08-18 Research News Copper has long been implicated as a contributory factor in the development of Alzheimer's disease, but the role of this divalent cation remains controversial. In this week's PNAS early online edition, Larry Sparks, Sun Health ...

Nicastrin—A DAPper Role in γ-Secretase

RESEARCH NEWS 2005-08-18 Research News Though we've known for some time now that the protein nicastrin is a major player in the γ-secretase complex (see ARF related news story), its exact role has remained somewhat elusive. But in last Friday's Cell, Gang Yu, Thomas ...

Presenilin—Guilty of Proteolysis by Association?

RESEARCH NEWS 2002-06-20 Research News Biology rarely re-invents the wheel. That is why proponents of the idea that presenilin (PS) and the proteolytic γ-secretases are one and the same will be pleased with a paper in tomorrow's Science by Bruno Martoglio and colleagues at ...

From Protein Trafficking to Episodic Memory: Tracing BDNF Genotypes

RESEARCH NEWS 2003-01-30 Research News An ambitious attempt to link cognitive tests, functional brain imaging, and cell biological assays implicates a polymorphism in brain-derived neurotrophic factor (BDNF) as the source for highly specific memory deficits, alterations in ...

Hormone Replacement Therapy Latest Entry to AlzRisk Database

RESEARCH NEWS 2011-11-03 Research News Despite almost two decades of research, it is not yet clear how hormone replacement therapy affects a woman’s risk of getting Alzheimer’s disease. The curators of the AlzRisk database, hosted by Alzforum, undertook a review of what the ...

Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation

RESEARCH NEWS 2003-03-03 Research News An article in the February 24 Nature Neuroscience online suggests that amyloid-β (Aβ), the peptide responsible for the intercellular plaques that appear in the brains of Alzheimer's patients, can freely diffuse through neural tissue, ...

A PD Trifecta: Synuclein Gene Expression, Aging, and Inflammation

RESEARCH NEWS 2008-07-26 Research News Starting from an unexpected finding that human blood contains abundant α-synuclein, a protein implicated in both hereditary and sporadic Parkinson disease, a trio of collaborators has unearthed an unlikely regulator of α-synuclein gene (SNCA ...

Caught in the Act—Amyloid Damages Neurons

RESEARCH NEWS 2004-10-15 Research News Since Alois Alzheimer’s first descriptions of senile plaques, we have known that they are associated with dementia. But are they detrimental? Are these amyloid-β (Aβ) deposits perpetrators or innocent bystanders? Nearly a century later, a ...

First Crystal Structure of a Presenilin

RESEARCH NEWS 2012-12-20 Research News In this week’s Nature, researchers report the first successful crystal structure of a bacterial presenilin homologue. The human presenilin forms the active part of the transmembrane γ-secretase complex that releases Aβ from its precursor, ...

Alzheimer’s in a Dish? Aβ Stokes Tau Pathology in Third Dimension

RESEARCH NEWS 2014-10-12 Research News Don your IMAX glasses. Researchers have taken a step closer to modeling Alzheimer’s disease in a dish by using a three-dimensional gel matrix. As described in Nature on October 12, researchers led by Doo Yeon Kim and Rudolph Tanzi at Harvard ...

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