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Varicose Axons: Traffic Jams Precede AD Pathology in Mice, Men

RESEARCH NEWS 2005-02-24 Research News Early in the course of Alzheimer disease, blockages in axonal traffic lead to sick axons swollen with the jumbled pile-up of traffic components. The blockages precede overt amyloid pathology in AD mouse models by a year and mark the brains ...

Aβ Star is Born? Memory Loss in APP Mice Blamed on Oligomer

RESEARCH NEWS 2006-03-17 Research News In a clever bit of sleuthing, Karen Ashe and colleagues appear to have solved the case of the mysterious memory loss in young mice engineered to express a mutated form of the human amyloid precursor protein (APP). Mysterious because the mice ...

Philadelphia: All Is Not Well with the Statin Story

CONFERENCE COVERAGE 2004-07-19 Conference Coverage One of the field’s biggest hopes for a quick and easy new AD therapy received a punch in the stomach today as the 9th International Conference on Alzheimer’s Disease and Related Disorders got under way in Philadelphia. John Breitner, ...

Statins and AD—What Role Isoprenoids?

RESEARCH NEWS 2005-02-28 Research News There has been considerable excitement generated by findings that statins, which lower plasma cholesterol, may help protect against Alzheimer disease (see Wolozin et al., 2000, Jick et al., 2000, and also ARF related news story that ...

Keystone: Death Receptor Ligand—New Role for APP, New Model for AD?

CONFERENCE COVERAGE 2009-02-20 Conference Coverage At the Keystone Symposium, Neurodegenerative Diseases: New Molecular Mechanisms on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session. Marc Tessier-Lavigne, Genentech Inc., San ...

Genetic Testing a Foggy Crystal Ball at Best?

RESEARCH NEWS 2012-04-04 Research News Sequencing a person’s entire genome will foretell many diseases only marginally better than gazing into a crystal ball, according to a report in the April 2 Science Translational Medicine online. Researchers at Johns Hopkins University in ...

CTAD: New Data on Sola, Bapi, Spark Theragnostics Debate

CONFERENCE COVERAGE 2012-11-09 Conference Coverage Held 29-31 October in the Principality of Monaco, the 5th Clinical Trials in Alzheimer’s Disease conference offered new data from ongoing analyses of the Phase 3 programs on solanezumab and bapineuzumab. Both programs missed their ...

Early Intervention Trial Bears Little Fruit, but Sows Hope

RESEARCH NEWS 2005-04-15 Research News Is the glass half empty or half full? Alzheimer disease (AD) clinicians might be asking themselves that question after seeing the long-awaited results of a large, prospective clinical study weighing the ability of vitamin E or the ...

Cholinergic Transmission and Aβ: Boosting M1 Receptors Treats Model

RESEARCH NEWS 2006-03-03 Research News An impressive data set that appeared yesterday in Neuron shows that a specific M1 muscarinic receptor agonist can reverse both cognitive deficits as well as the amyloid and tau pathology in the APP/PS1/tau triple transgenic mice mouse model ...

Coping with Copper—Minute Amount of Metal Plagues Rabbit Brain

RESEARCH NEWS 2003-08-18 Research News Copper has long been implicated as a contributory factor in the development of Alzheimer's disease, but the role of this divalent cation remains controversial. In this week's PNAS early online edition, Larry Sparks, Sun Health ...

Nicastrin—A DAPper Role in γ-Secretase

RESEARCH NEWS 2005-08-18 Research News Though we've known for some time now that the protein nicastrin is a major player in the γ-secretase complex (see ARF related news story), its exact role has remained somewhat elusive. But in last Friday's Cell, Gang Yu, Thomas ...

Presenilin—Guilty of Proteolysis by Association?

RESEARCH NEWS 2002-06-20 Research News Biology rarely re-invents the wheel. That is why proponents of the idea that presenilin (PS) and the proteolytic γ-secretases are one and the same will be pleased with a paper in tomorrow's Science by Bruno Martoglio and colleagues at ...

From Protein Trafficking to Episodic Memory: Tracing BDNF Genotypes

RESEARCH NEWS 2003-01-30 Research News An ambitious attempt to link cognitive tests, functional brain imaging, and cell biological assays implicates a polymorphism in brain-derived neurotrophic factor (BDNF) as the source for highly specific memory deficits, alterations in ...

Hormone Replacement Therapy Latest Entry to AlzRisk Database

RESEARCH NEWS 2011-11-03 Research News Despite almost two decades of research, it is not yet clear how hormone replacement therapy affects a woman’s risk of getting Alzheimer’s disease. The curators of the AlzRisk database, hosted by Alzforum, undertook a review of what the ...

Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation

RESEARCH NEWS 2003-03-03 Research News An article in the February 24 Nature Neuroscience online suggests that amyloid-β (Aβ), the peptide responsible for the intercellular plaques that appear in the brains of Alzheimer's patients, can freely diffuse through neural tissue, ...

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