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Merck Pulls Plug on Phase 2/3 BACE Inhibitor Trial

RESEARCH NEWS 2017-02-15 Research News Merck dropped a Valentine’s Day downer announcing they will stop the EPOCH trial of verubecestat  in mild to moderate Alzheimer’s disease. A prespecified interim analysis by an external data-monitoring committee gave the trial “virtually no ...

Semagacestat, a Pseudo γ-Secretase Inhibitor?

RESEARCH NEWS 2017-10-12 Research News Seven years after semagacestat failed in Phase 3 clinical trials for Alzheimer’s disease, researchers led by Masayasu Okochi at Osaka University, Japan, offer a new reason why. In the October 3 Cell Reports, the scientists claim that the γ ...

Lymphatic Brain Drain Withers in Aging, Worsens Disease

RESEARCH NEWS 2018-07-27 Research News In recent years, scientists have characterized a hidden set of lymphatic vessels in the meninges, the membranes that line the skull and envelope the brain (Oct 2017 news). These meningeal lymphatic vessels carry waste from the cerebrospinal ...

Immunotherapy Update: Toward Patches and Creams

RESEARCH NEWS 2007-01-25 Research News In the future, could Alzheimer disease treatments come as an ointment, or a skin patch? That may not be as far out as it seems, with a new study published this week in PNAS online showing that mice produce amyloid-clearing antibodies after ...

ApoE Binds Complement Protein, Keeps Inflammatory Cascade in Check

RESEARCH NEWS 2019-02-01 Research News This story was updated on February 5, 2019. Just when you thought ApoE biology couldn’t get any more complicated, scientists have discovered a new function for this apolipoprotein. According to a January 28 paper in Nature Medicine, ApoE ...

Does a Breached Blood-Brain Barrier Cause Seizures in AD?

RESEARCH NEWS 2019-12-06 Research News In back-to-back papers in the December 4 Science Translational Medicine, scientists led by Daniela Kaufer, University of California, Berkeley, and Alon Friedman, Ben-Gurion University of the Negev, Beer-Sheva, Israel, report that age-related ...

Gaining Notoriety, SORL1 Claims Spot Among Top Alzheimer’s Genes

RESEARCH NEWS 2018-06-07 Research News In the complex genetics of Alzheimer’s, only a handful of genes by themselves have a massive impact on risk. ApoE4 and TREM2 boost a person’s odds of late-onset AD from three- to 12-fold, and the three autosomal-dominant genes APP, PS1, and ...

Aberrant Networks in Alzheimer’s Tied to Herpes Viruses

RESEARCH NEWS 2018-06-21 Research News An extensive, multi-cohort, multi-network analysis of what goes wrong in the Alzheimer’s brain and why, has turned up none other than human herpes and other viruses. The big data analyses, a four-year project, is detailed in the June 21 ...

The Alzheimer's Vaccination Story, Continued

RESEARCH NEWS 2002-10-16 Research News Ever since the phase two clinical trial of Elan's Aβ peptide vaccine was halted (see live discussion), the community has pondered if a vaccine against this disease will ever reach the clinic. Many questions surround both the rationale ...

Varicose Axons: Traffic Jams Precede AD Pathology in Mice, Men

RESEARCH NEWS 2005-02-24 Research News Early in the course of Alzheimer disease, blockages in axonal traffic lead to sick axons swollen with the jumbled pile-up of traffic components. The blockages precede overt amyloid pathology in AD mouse models by a year and mark the brains ...

Aβ Star is Born? Memory Loss in APP Mice Blamed on Oligomer

RESEARCH NEWS 2006-03-17 Research News In a clever bit of sleuthing, Karen Ashe and colleagues appear to have solved the case of the mysterious memory loss in young mice engineered to express a mutated form of the human amyloid precursor protein (APP). Mysterious because the mice ...

Philadelphia: All Is Not Well with the Statin Story

CONFERENCE COVERAGE 2004-07-19 Conference Coverage One of the field’s biggest hopes for a quick and easy new AD therapy received a punch in the stomach today as the 9th International Conference on Alzheimer’s Disease and Related Disorders got under way in Philadelphia. John Breitner, ...

Statins and AD—What Role Isoprenoids?

RESEARCH NEWS 2005-02-28 Research News There has been considerable excitement generated by findings that statins, which lower plasma cholesterol, may help protect against Alzheimer disease (see Wolozin et al., 2000, Jick et al., 2000, and also ARF related news story that ...

Keystone: Death Receptor Ligand—New Role for APP, New Model for AD?

CONFERENCE COVERAGE 2009-02-20 Conference Coverage At the Keystone Symposium, Neurodegenerative Diseases: New Molecular Mechanisms on Wednesday, debate on the last plenary talk continued around the dinner table and well into the poster session. Marc Tessier-Lavigne, Genentech Inc., San ...

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