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RESEARCH NEWS 2015-07-02 Research News The monoamine oxidase B inhibitor sembragiline missed its primary endpoint in a Phase 2b trial of more than 500 patients with moderate Alzheimer’s disease (see company news release). Developed jointly by Evotec AG in Hamburg, Germany and R
RESEARCH NEWS 2015-07-03 Research News Imagine glimpsing a celebrity taking a selfie at the Eiffel Tower and later relaying that split-second encounter to a friend. How did your brain form a memory of that one episode? A group led by Rodrigo Quian Quiroga, University of Leicester
RESEARCH NEWS 2015-07-09 Research News Beyond the four-letter alphabet of the genome, a far richer code dictates when and where genes are transcribed. The epigenome—defined by an ever-expanding list of modifications to DNA and the proteins that interact with it—determines which g
RESEARCH NEWS 2015-07-10 Research News When given blood from old mice, young mice age quickly, implying that some factor lurks in the circulatory milieu to speed the aging process (see May 2014 news story). In the July 6 Nature Medicine, scientists led by Saul Villeda, University
COMMUNITY NEWS 2015-07-15 Community News Paul Aisen’s departure from the University of California San Diego on June 21, to head up a new Alzheimer's institute affiliated with the University of Southern California, has precipitated an acrimonious, public feud that is being wid
RESEARCH NEWS 2015-07-17 Research News In amyotrophic lateral sclerosis, motor neurons struggle with axonal transport, autophagy, and mitochondrial maintenance. A July 15 paper in Neuron unites those three processes in a single theory: the mutant ALS protein SOD1 obstructs tran
COMMUNITY NEWS 2015-07-20 Community News This year’s MetLife Foundation Awards for Medical Research go to two researchers well known to Alzforum: Randall Bateman of Washington University School of Medicine, St. Louis, and Christian Haass of Ludwig Maximilians University and the Ge
RESEARCH NEWS 2015-07-24 Research News The brain would be much easier to see if that pesky skull was not there. Now, using a deformable mirror to correct the light it disperses, researchers led by Meng Cui at the Howard Hughes Medical Institute in Ashburn, Virginia, have come clo
RESEARCH NEWS 2015-07-24 Research News Traumatic brain injury can cause aggregation and accumulation of tau, leading to a condition called chronic traumatic encephalopathy (CTE). Scientists are unsure whether tau pathology is a cause or simply a consequence of CTE. A new study le
COMMUNITY NEWS 2015-07-31 Community News On July 31, 2014, former college baseball player Pete Frates uploaded a 52-second video to Facebook. Frates, who has amyotrophic lateral sclerosis, bobbed his head to the tune of “Ice Ice Baby.” While he stayed dry to protect his health, Fr
RESEARCH NEWS 2015-08-05 Research News Hot flashes, mood swings, and insomnia are just a few of the troubling symptoms of menopause, and all of them are caused by a lack of estrogen in the brain. Women can take hormone replacement therapy to ease these tortures, but the drugs car
CONFERENCE COVERAGE 2015-08-05 Conference Coverage TREM2 mutations raise one’s risk for Alzheimer’s disease—but which variants cause problems, and how? Researchers wrestling with these questions presented their latest results at the Alzheimer’s Association International Conference 2015
CONFERENCE COVERAGE 2015-08-06 Conference Coverage “My life feels like I am visiting in someone’s house and hear a grandfather’s clock ticking. I fight back by being in DIAN and speaking publicly. It’s the control I have over my genetic destiny.” Brian Whitney, 44. “I’ve never before m
CONFERENCE COVERAGE 2015-08-06 Conference Coverage The first Autosomal-Dominant AD Family Conference of the Dominantly Inherited Family Network (see Part 1) showcased gaps in legal, financial, and caregiver-support systems. On a more hopeful note, the families heard that the chronic lo
CONFERENCE COVERAGE 2015-08-07 Conference Coverage On the morning of July 18, 100 participants in the Dominantly Inherited Alzheimer’s Network (DIAN) spent four hours cooped up in a windowless hotel meeting room talking about the genetic, financial, and legal complications of life with
