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Paper Alert: Mouse TREM2 Antibody Boosts Microglial Plaque Clean-Up

RESEARCH NEWS 2020-03-10 Research News A new antibody turbocharges TREM2, the most ardent supporter of microglia. In mice, that is. According to a study published March 10 in the EMBO Journal, a monoclonal antibody trained against the mouse microglial receptor prevents shedding ...

Genetic Wild West: 23andMe Raw Data Contains 75 Alzheimer’s Mutations

COMMUNITY NEWS 2017-07-11 Community News The spit tube arrives in the mail in a pretty box, stamped with the cheery message “Welcome to You.” The journey into your genome begins a few weeks later, with an email inviting you, a 23andMe customer, to explore your DNA. You’ll learn ...

Treating Tau: Finally, Clinical Candidates Are Stepping into the Ring

CONFERENCE COVERAGE 2017-04-27 Conference Coverage While many of the more advanced Alzheimer’s therapies currently in trials target amyloid, tau-based approaches are stepping up to the plate. At the 13th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 29 to ...

Off-Balance Endocytosis Lays Groundwork for Disease

CONFERENCE COVERAGE 2019-05-03 Conference Coverage Endocytosis is implicated in Alzheimer’s pathogenesis, because the continuous swallowing up of proteins from the cell surface and packaging them into little organelles brings the amyloid precursor protein (APP) into contact with the ...

Parsing How Alzheimer’s Genetic Risk Works Through Microglia

CONFERENCE COVERAGE 2019-04-23 Conference Coverage Much of the genetic risk of Alzheimer’s disease plays out in microglia. But exactly how do risk variants change these cells? At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, ...

Alzheimer’s GWAS Hits Point to Endosomes, Synapses

CONFERENCE COVERAGE 2015-11-13 Conference Coverage In taking a closer look at the Alzheimer’s risk genes enlisted by genome-wide association studies, researchers at this year’s Society for Neuroscience annual meeting, held October 17-21 in Chicago, showed off what confocal and super ...

A Delicate Frontier: Human Microglia Focus of Attention at Keystone

CONFERENCE COVERAGE 2018-07-13 Conference Coverage For a pesky cell type that comprises a small fraction of cells in the brain, microglia have an outsize impact on neurodegeneration. Many of the Alzheimer’s risk loci identified in genome-wide association studies harbor genes expressed ...

New at Tau2020: PET Detects First Traces of Tangles in Rhinal Cortex

CONFERENCE COVERAGE 2020-03-05 Conference Coverage Tau2020, the first of what may become a regular “pan-tau” conference (see Part 1 of this series), got off to a brisk start February 12–13 in Washington, D.C. Researchers who focus on primary tauopathies, such as progressive ...

Dementia Research Institute to Double U.K. Coronavirus Testing

COMMUNITY NEWS 2020-03-24 Community News While science groups worldwide are grappling with the logistics of shutting down to comply with the social distancing required to slow the spread of COVID-19, neurodegenerative disease researchers are asking how they can help. And help they ...

A ‘Perfect Storm’ for Families Grappling with Dementia

COMMUNITY NEWS 2020-03-28 Community News As the COVID-19 pandemic engulfs the globe, it puts extraordinary strain on at-risk groups—very much including people with neurodegenerative disease and their carers. Not only do most people with neurodegenerative diseases fall into the age ...

Study Looks to Lithium for Treating ALS—Patients Follow Suit

RESEARCH NEWS 2008-02-27 Research News The drug lithium is usually prescribed to patients with bipolar disorder. But evidence is growing that it might help with some neurodegenerative diseases as well, particularly the rapid and devastating Lou Gehrig's disease, known as ...

A Phospho-Tau Plasma Assay for Alzheimer’s?

RESEARCH NEWS 2020-03-31 Research News Researchers stunned the field last summer when they reported that phosphorylated tau turns up in peoples’ plasma decades before they show signs of dementia. The data bore the promise of a blood test for early Alzheimer’s disease—one that is ...

Low-Dose Aspirin Does Not Prevent AD, or Slow Cognitive Decline

RESEARCH NEWS 2020-04-01 Research News An aspirin a day does not keep dementia away. Nor does it hedge the risk of mild cognitive impairment or slow decline, according to results published March 25 in Neurology. Reasoning that the anti-inflammatory and cardiovascular health ...

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