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Paper Alert: Phase 3 Trial Data Published on Sleep Aid Suvorexant

RESEARCH NEWS 2020-02-13 Research News Nighttime wakefulness and wandering are common symptoms in Alzheimer’s disease, but doctors hesitate to prescribe sleep-enhancing drugs because those have been linked to worsening cognition and falls. Results from a Phase 3 trial published ...

New Myelin Makes Memories, but Supply Wanes with Age

RESEARCH NEWS 2020-02-14 Research News While the vast majority of myelin sheaths in the brain are laid down early in life, a pair of new studies published February 10 in Nature Neuroscience reveal that a fresh supply of the fatty axonal conductor is required to establish and ...

International Symposium Puts PSP/CBD on the Map

CONFERENCE COVERAGE 2018-11-08 Conference Coverage Progressive supranuclear palsy and corticobasal degeneration are rare, poorly understood tauopathies with a broad array of symptoms and subtypes. What causes them? How to prevent, diagnose, track, and treat them? On October 25 and 26, ...

Retinal Gene Therapy Trial Posts Positive Result

RESEARCH NEWS 2020-02-24 Research News Another gene therapy for a central nervous system disorder has posted positive results. The Phase 1/2 trial enrolled 18 men with X-linked retinitis pigmentosa (RP), a disease of retinal degeneration that leads to blindness. Robert MacLaren ...

Fluid NfL Shines, Tau PET Dims, in the Hunt for FTD Biomarkers

CONFERENCE COVERAGE 2016-09-29 Conference Coverage Biomarkers are the obsession du jour in frontotemporal dementia research. Over and over at the 10th International Conference on Frontotemporal Dementias, held August 31-Septemper 2 in Munich, speakers emphasized the need for new ...

Tau-PET in Down’s: Unique Patterns Among Alzheimer’s Types and Stages

CONFERENCE COVERAGE 2016-12-22 Conference Coverage By the time memory frays, the brains of people with Alzheimer’s disease are already infested with Aβ plaques, but the growth of tau tangles tracks with worsening symptoms. With tau PET, researchers now have a tool to watch this happen, ...

Data from DIAN Revise Familiar Biomarker Trajectories

CONFERENCE COVERAGE 2017-08-22 Conference Coverage Part 1 of a two-part story. As researchers analyze data in longitudinal biomarker studies, they find that some previously estimated biomarker trajectories do not hold up. At the Alzheimer’s Association International Conference 2017, ...

PET Tracer Detects Synapse Loss Across Alzheimer’s Brain

CONFERENCE COVERAGE 2020-02-07 Conference Coverage Part 1 of a 2-part story. A PET tracer that lights up synapses is able to detect a loss of connectivity across the Alzheimer’s brain, according to new research presented at the Human Amyloid Imaging conference, held January 15–17 in ...

Can PET Match Up Areas of Protein Deposit With Alzheimer’s Symptoms?

CONFERENCE COVERAGE 2020-02-26 Conference Coverage Even though, overall, Alzheimer’s disease robs all people it afflicts of mind and memory, it progresses differently in different people. Its specific symptoms, their sequence, and how fast they worsen can vary quite a bit from one ...

How Much Amyloid Will Kick Off Tangles, and Decline?

CONFERENCE COVERAGE 2020-02-29 Conference Coverage As more research groups are conducting brain imaging in Alzheimer’s disease, separately and on different continents, their data nonetheless converge into a confirmation overall of the disease’s basic progression pathway: plaques, then ...

Is Too Much Vitamin B12 a Health Hazard?

RESEARCH NEWS 2020-01-24 Research News Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan ...

Tau2020: Meeting for Tauopathies Debuts Genetic Variants

CONFERENCE COVERAGE 2020-03-03 Conference Coverage Tau2020, a new international conference on all things—you guessed it—tau, unfolded in Washington, D.C, February 12 to13. This open meeting grew out gatherings of the Tau Consortium held in previous years, which were funded by the ...

Truly New to Déjà Vu: For Five Hopefuls, Lights Go Out After Phase 2

CONFERENCE COVERAGE 2015-11-25 Conference Coverage More candidate therapies have landed on the scrap heap of Alzheimer’s clinical trials, freeing up sites, investigators, and participants to try something else. At the 8th Clinical Trials on Alzheimer’s Disease conference, held November ...

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