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RESEARCH NEWS 2015-03-28 Research News Tiny brain bleeds in Alzheimer’s patients put them at a higher risk of stroke and cardiovascular disease. Which one develops depends on where those microbleeds occur, according to the latest findings from the MISTRAL Study. Scientists led by
CONFERENCE COVERAGE 2015-03-31 Conference Coverage People with Parkinson’s disease have treatment options, but none directly tackle the underlying pathology of misfolded and aggregated α-synuclein. That may be poised to change, with numerous approaches targeting the protein now in the
CONFERENCE COVERAGE 2015-04-01 Conference Coverage Striving to be noticed in the hoopla over Biogen’s Phase 1 aducanumab data, other investigational therapies presented clinical data at the 12th International Conference on Alzheimer’s and Parkinson’s diseases, held March 18 to 22 in Ni
RESEARCH NEWS 2015-04-02 Research News In some people who carry a repeat expansion in the C9ORF72 gene, methylation of the gene promoter shuts down its transcription. This offers a modicum of protection against amyotrophic lateral sclerosis and frontotemporal dementia, according
COMMUNITY NEWS 2015-04-03 Community News If you think there are too few journals on Alzheimer’s research, take heart. Two open-access companion publications of Alzheimer’s & Dementia, The Journal of the Alzheimer’s Association, make their debuts this spring. Published by Elsev
RESEARCH NEWS 2015-04-03 Research News The tumor suppressor p53, well known to shield cells from DNA damage, may also protect against malformed proteins, according to a paper in the April 2 PLoS Biology. First author Goran Periz and colleagues at Johns Hopkins University in Balti
RESEARCH NEWS 2015-04-03 Research News In the age of the Internet, don’t you love it when you get a real letter? Especially a letter from your friendly FDA regulator. That’s how the field learned that the Food and Drug Administration is—now a bit more formally than before—in favo
RESEARCH NEWS 2015-04-03 Research News Protein production is a noisy business. No, not the clangs and bangs of the ribosome, but the random fluctuations in the amount of protein produced by specific genes. How does a cell keep this kind of noise in check? With microRNAs, accordin
RESEARCH NEWS 2015-04-08 Research News Two measures of Aβ are used routinely to identify people who might be at risk for Alzheimer's disease—a drop in soluble Aβ42 in the cerebrospinal fluid (CSF), and the uptake of ligands that bind amyloid plaques in the brain. How do the
CONFERENCE COVERAGE 2015-04-10 Conference Coverage An unusual, oligomer-morphing peptide therapy may soon graduate from preclinical studies into human trials for Alzheimer’s disease. Comprising D-amino acids, the peptides resist digestion by proteases that would make quick work of thei
CONFERENCE COVERAGE 2015-04-10 Conference Coverage The laundry list of potential Alzheimer’s risk genes that have turned up in genome-wide association studies explains but a fraction of the total genetic burden of the disease, so geneticists are turning to whole-genome and exome sequen
CONFERENCE COVERAGE 2015-04-10 Conference Coverage Changes in shape and structure can turn a well-behaved cellular protein into something altogether more sinister, but in many cases researchers do not know exactly which modifications are at fault. At the 12th International Conference o
RESEARCH NEWS 2015-04-11 Research News Could a protein that ramps up in response to stress also hold the key to making memories? According to a paper in the April 9 Cell Reports, the transcription factor ATF4 is necessary for synaptic plasticity in the hippocampus and for spatial
CONFERENCE COVERAGE 2015-04-14 Conference Coverage The once-outlandish idea that misfolded proteins can propagate through the brain along anatomical connections has gone mainstream. At the 12th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 18-22 in Nice,
RESEARCH NEWS 2015-04-15 Research News Brains are high-maintenance. All that thinking accounts for a whopping 25 percent of the glucose a body burns, and 20 percent of the oxygen it consumes, yet the stuff inside the noggin only weighs about three pounds—a mere 2 percent of the b
