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At Least We Know These Don’t Work: Negative Trials at CTAD

CONFERENCE COVERAGE 2017-12-15 Conference Coverage Confirming once again that not only anti-amyloid therapeutic approaches struggle to score a win in Alzheimer’s and related dementias, the 10th CTAD conference, held November 1–4 in Boston, featured rest-in-peace presentations on a ...

Minocycline Does Not Work in Mild Alzheimer’s Disease

RESEARCH NEWS 2019-11-22 Research News Treatment with the antibiotic minocycline failed to slow cognitive decline or functional impairment in patients with mild Alzheimer’s disease, according to a November 18 paper in JAMA Neurology. Researchers led by Robert Howard, University ...

Experts Slam Marketing of Tramiprosate (Alzhemed) as Nutraceutical

RESEARCH NEWS 2008-10-10 Research News In a move that has drawn criticism from leading researchers and the Alzheimer’s Association, the Canadian pharmaceutical company Bellus Health has begun to sell the would-be prescription drug tramiprosate (aka Alzhemed or homotaurine) over ...

Gosuranemab, Biogen’s Anti-Tau Immunotherapy, Does Not Fly for PSP

RESEARCH NEWS 2019-12-13 Research News Biogen announced today that its anti-tau passive immunotherapy, gosuranemab, had failed to pass muster in a Phase 2 trial for people with progressive supranuclear palsy. Biogen will continue testing the immunotherapy in the Phase 2 TANGO ...

Are Aβ Blood Tests Ready for Prime Time?

CONFERENCE COVERAGE 2019-08-21 Conference Coverage In the short space of two years, the erstwhile fantasy of a blood test for Alzheimer’s disease has become reality. Or so it seems. At the 2017 Alzheimer’s Association International Conference in London, Randall Bateman, Washington ...

Move Over Aβ, CSF P-Tau Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage Just as labs around the globe are racing to start marketing plasma Aβ tests, along come new contenders to rattle the field. At this year’s AAIC, held July 14-18 in Los Angeles, scientists reported that certain amino acids on the ...

Move Over CSF, P-Tau in Blood Also Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage From day one at this year’s AAIC, held July 14-18 in Los Angeles, conference halls and corridors buzzed with the sound of “p-tau.” Scientists from Randall Bateman ’s lab at Washington University, St. Louis, reported that among ...

Synaptic Proteins in CSF: New Markers of Cognitive Decline?

CONFERENCE COVERAGE 2019-08-22 Conference Coverage Plasma tests for Aβ and phospho-tau may have stolen the show at this year’s Alzheimer’s Association International Conference, held July 14-18 in Los Angeles, but proteomic and synaptic markers were not that far behind. A neural ...

Blood Tests of Phospho-Tau, Aβ42, Track With Brain Amyloid

CONFERENCE COVERAGE 2019-12-19 Conference Coverage While a suite of new CSF markers has entered a mature stage where they get validated with identical methods in large international cohorts (see previous CTAD story), much newer blood tests are catching up fast. Scientists are pushing ...

Amyloid Clearance: Check. Cognitive Benefit: Um … Maybe.

CONFERENCE COVERAGE 2019-12-20 Conference Coverage With aducanumab’s resurrection driving renewed interest in anti-amyloid antibody therapies, researchers at the 12th Clinical Trials on Alzheimer’s Disease conference, held December 4–7 in San Diego, happily provided updates on their ...

Geneticists Seek Out Rare Contributors to Alzheimer’s

CONFERENCE COVERAGE 2019-08-15 Conference Coverage At one end of the Alzheimer’s disease genetic spectrum lie the catastrophic mutations in APP and presenilin that lead to autosomal-dominant, early onset AD. At the other end are dozens of common variants that each contribute a smidgen ...

Innate Immune Cells Enlisted to Clear Amyloid, Fight Disease

CONFERENCE COVERAGE 2013-12-05 Conference Coverage This concludes a two-part story. Read part one here. As researchers flesh out connections between the brain and the immune system, they are beginning to understand the role microglia play in disease. Prior research had blamed ...

Going Indirect: Can Therapies Halt Alzheimer’s from Outside the Brain?

CONFERENCE COVERAGE 2019-12-21 Conference Coverage For therapies taking aim at Alzheimer’s disease, exerting an effect in the brain seems critical. And obvious. But according to results on display at 12th Clinical Trials on Alzheimer’s Disease conference, held December 4–7 in San Diego ...

Senate Ups Funding for Alzheimer’s Research by $350 million for 2020

COMMUNITY NEWS 2019-12-23 Community News Continuing a steady climb in funding for Alzheimer’s research, the Senate approved a $350 million increase in funding for Alzheimer’s and dementia research at the National Institutes of Health for the 2020 fiscal year. The appropriation ...

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