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TADPOLE Challenge: Winners Forecast AD Symptoms

COMMUNITY NEWS 2019-06-19 Community News Results are in for the TADPOLE Challenge—a prize contest that invited researchers to come up with their own ways of predicting dementia symptoms in participants enrolled in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). In a live ...

New Tool: Microglia-Specific Reporter Mice, With Choice of Colors

RESEARCH NEWS 2019-06-26 Research News Microglia, the ever-changing resident immune cells of the central nervous system, have come under intense scrutiny for their role in Alzheimer’s disease and other neuroinflammatory conditions. Tracking these famously elusive cells just got ...

Sliced by ApoE Genotype, Whole Exome Data Yield New AD Variants

RESEARCH NEWS 2019-06-14 Research News Does the head honcho of genetic Alzheimer’s risk occlude contributions of smaller genes? In the June 10 JAMA Neurology, researchers led by Lindsay Farrer at Boston University exposed some hidden variants that have languished in the shadow of ...

Meet medRχiv: A New Preprint Server for Health Research

COMMUNITY NEWS 2019-06-25 Community News Today the co-founders of the preprint server bioRχiv, together with The BMJ in London and Yale University in New Haven, Connecticut, launch a sister repository for research papers in the medical sciences. Called medRχiv, this free, ...

Down to Sex? Boy and Girl Microglia Respond Differently

CONFERENCE COVERAGE 2019-07-02 Conference Coverage Some microglia are from Mars; others from Venus. Well, no. But in some scenarios, to which sex a microglial cell belongs appears to hold some sway over how it responds. Consider tau. At a joint Keystone symposia—Neurodegenerative ...

TREM2, Microglia Dampen Dangerous Liaisons Between Aβ and Tau

CONFERENCE COVERAGE 2019-07-02 Conference Coverage That microglia play a central role in neurodegenerative disease has become a premise; it’s no longer a question. The questions are all about the how. This was abundantly clear at joint symposia held June 16–21 in Keystone, Colorado. At ...

Dopaminergic Neurons Conjured from Astrocytes Restore Motion

CONFERENCE COVERAGE 2019-07-05 Conference Coverage Astrocytes are devoted nurturers of neurons—facilitating synaptic transmission, maintaining the blood-brain barrier, and repairing injuries are but a few of their ministrations. As if that weren’t enough, scientists described an ...

Invading T Cells Quash Neurogenesis

RESEARCH NEWS 2019-07-06 Research News Adult mammalian brains eke out limited numbers of new neurons in select regions, but over time, even that production dwindles. Why is unclear. New evidence from the lab of Anne Brunet, Stanford University, California, suggests invading ...

Epilogue on Edonerpic: It Does Not Work in Alzheimer’s

RESEARCH NEWS 2019-07-10 Research News The drug edonerpic maleate failed to slow cognitive decline in Alzheimer’s patients, according to a paper published online July 8 in JAMA Neurology. Scientists led by Lon Schneider, University of Southern California, Los Angeles, reported ...

Gently Used: Can Recycled Microglia Receptors Prevent Plaque?

RESEARCH NEWS 2019-06-28 Research News Microglia do much of the heavy lifting when it comes to removing Aβ, but how do they do it? Researchers led by Douglas Green, St. Jude Children’s Research Hospital, Memphis, Tennessee, have identified an endocytic recycling process by which ...

Deleting CD33 Benefits Mice—If Their Microglia Express TREM2

RESEARCH NEWS 2019-07-11 Research News From their perch on the microglial surface, CD33 and TREM2 exact opposing forces on microglial functions, including phagocytosis and inflammatory responses. Now, in a study published in Neuron on July 10, researchers led by Rudolph Tanzi at ...

In PD Model, α-Synuclein Spreads from Intestine to Brain

CONFERENCE COVERAGE 2019-07-12 Conference Coverage The hypothesis that Parkinson’s disease could arise within the belly, not the brain, now gains support with a new mouse model. Valina Dawson of Johns Hopkins University, Baltimore, reported at a joint symposium held June 16-21 in ...

Microglia Control Synapse Number in Multiple Disease States

CONFERENCE COVERAGE 2015-11-03 Conference Coverage What causes synapses to wither in neurodegenerative diseases such as Alzheimer’s? Some researchers blame reactivation of microglia, which prune unneeded synapses during brain development. At the Society for Neuroscience meeting held in ...

New Tool Kit Helps Physicians Recognize and Manage Lewy Body Dementias

CONFERENCE COVERAGE 2019-07-19 Conference Coverage Lewy body dementia, the second-most-common progressive dementia after Alzheimer’s disease, receives relatively little attention and few research dollars, and often goes undiagnosed. Comedian Robin Williams, perhaps the most famous ...

Can Researchers Detect Dementia With Lewy Bodies at the Prodromal Stage?

CONFERENCE COVERAGE 2019-07-21 Conference Coverage For neurodegenerative disease, the mantra is “go early,” based on the theory that intervention at prodromal stages may be most effective. Early detection could also help patients and families plan for the future, and avoid drugs ...

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