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Paper Alert: MS4A Variants May Sway Alzheimer’s Risk Via TREM2

RESEARCH NEWS 2019-08-15 Research News Variants in the MS4A gene cluster influence AD risk, at least in part, by tweaking levels of another AD risk factor, TREM2. In a study published in Science Translational Medicine on August 14, researchers co-led by Bruno Benitez, Celeste ...

Move Over Aβ, CSF P-Tau Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage Just as labs around the globe are racing to start marketing plasma Aβ tests, along come new contenders to rattle the field. At this year’s AAIC, held July 14-18 in Los Angeles, scientists reported that certain amino acids on the ...

Why Bother With Round Robins on Blood Tests? Q&A with Kaj Blennow

CONFERENCE COVERAGE 2019-08-21 Conference Coverage At the AAIC conference held July 14–18 in Los Angeles, Kaj Blennow of the University of Gothenburg had his hands full trying to get researchers in the field engaged in the nitpicky drudgery of validation, standardization, and ...

Synaptic Proteins in CSF: New Markers of Cognitive Decline?

CONFERENCE COVERAGE 2019-08-22 Conference Coverage Plasma tests for Aβ and phospho-tau may have stolen the show at this year’s Alzheimer’s Association International Conference, held July 14-18 in Los Angeles, but proteomic and synaptic markers were not that far behind. A neural ...

Proteomics Uncovers Potential Markers, Subtypes of Alzheimer’s

CONFERENCE COVERAGE 2019-08-22 Conference Coverage In the last three decades, scientists have made strides in using biomarkers to diagnose Alzheimer’s disease and track its progression. Along with cerebrospinal fluid Aβ, tau, and phospho-tau, a handful of new markers, such as ...

Brain Conference Spotlights Transcriptomics, Therapeutic Strategies

CONFERENCE COVERAGE 2019-05-24 Conference Coverage About 140 scientists gathered in Rungstedgaard, north of Copenhagen, Denmark, May 5–9 for the biannual Brain Conference organized by the Federation of European Neuroscience Societies and the Lundbeck Foundation. Co-chaired by Beth ...

Move Over CSF, P-Tau in Blood Also Tells Us There’s Plaque in the Brain

CONFERENCE COVERAGE 2019-08-20 Conference Coverage From day one at this year’s AAIC, held July 14-18 in Los Angeles, conference halls and corridors buzzed with the sound of “p-tau.” Scientists from Randall Bateman ’s lab at Washington University, St. Louis, reported that among ...

Are Aβ Blood Tests Ready for Prime Time?

CONFERENCE COVERAGE 2019-08-21 Conference Coverage In the short space of two years, the erstwhile fantasy of a blood test for Alzheimer’s disease has become reality. Or so it seems. At the 2017 Alzheimer’s Association International Conference in London, Randall Bateman, Washington ...

Nixing Complement Protein Protects Neurons in Tauopathy Model

RESEARCH NEWS 2019-08-25 Research News Complement proteins may be helpful when it comes to rallying clearance of hazardous debris from the brain, but scientists believe the immune activators can also inflict irreparable damage to neurons and their synapses. A paper published ...

Refining Models of Amyloid Accumulation in Alzheimer’s Disease

CONFERENCE COVERAGE 2016-08-29 Conference Coverage The knowledge that Alzheimer’s disease begins with a preclinical phase that lasts for 20 years or more has focused researchers’ minds on prevention. However, they need to know more about how fast pathology progresses, how to predict ...

Raw Deal: Lose Ataxin, Gain BACE

RESEARCH NEWS 2019-08-29 Research News CAG trinucleotide repeat expansions in the ataxin-1 gene cause spinocerebellar ataxia type 1, a fatal neurodegenerative disease. Curiously, variants of this same gene, sans trinucleotide repeat expansions, associate with risk for Alzheimer’s ...

Technology Brings Dementia Detection to the Home

CONFERENCE COVERAGE 2019-08-30 Conference Coverage The past decade has seen increasing use of technology in dementia research. Computer games that provide cognitive training have become part of prevention studies, and trialists are working to move cognitive testing out of the clinic ...

Smart Homes Open Doors to Insights into Aging, Dementia

CONFERENCE COVERAGE 2019-08-30 Conference Coverage Replicating existing paper-and-pencil tests on tablets or smartphones is one thing (Part 13 of this series), but what about taking technology itself to the next level? What are the prospects for continuously collecting information on ...

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