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RESEARCH NEWS 2014-09-26 Research News The lymphoma drug bexarotene, under cross-examination as an Alzheimer’s therapeutic, dramatically lowers soluble Aβ in mice in some studies but not others. A paper in the September 12 Journal of Biological Chemistry offers an explanation for
RESEARCH NEWS 2014-09-26 Research News Researchers have connected the dots in a pivotal pathway that they believe may tip the balance toward Alzheimer’s disease. In a study published September 17 in Neuron, Guojun Bu at the Mayo Clinic in Jacksonville, Florida, and colleagues rep
RESEARCH NEWS 2014-09-26 Research News Scientists have deduced the mode of action for a powerful neuroprotective drug class and are now trying to develop a compound into a therapy. On September 11, collaborators from the University of Texas Southwestern Medical Center in Dallas,
RESEARCH NEWS 2014-09-27 Research News TDP-43 self-assembles into oligomers that are able to recruit Aβ to form oligomers of its own, claims a paper in the September 12 Nature Communications. Using a new TDP-43 oligomer antibody, the authors report binding in postmortem brain sam
RESEARCH NEWS 2014-09-27 Research News A perceived slip in memory could signal future cognitive decline, suggests a paper in the October 7 Neurology. Researchers led by Richard Kryscio, University of Kentucky, Lexington, found that ostensibly normal volunteers who reported a subj
CONFERENCE COVERAGE 2014-10-01 Conference Coverage For consummate physician-researchers, what better way to mark an auspicious anniversary than with a scientific meeting? So it was that some 250 researchers gathered at Massachusetts General Hospital on September 19 to celebrate the 30t
RESEARCH NEWS 2014-10-03 Research News Progranulin mutations predispose to frontotemporal dementia (FTD), but growing evidence suggests they can heighten the risk for Alzheimer’s disease as well. A paper in the September 28 Nature Medicine now sheds some light on the mechanism be
RESEARCH NEWS 2014-10-09 Research News Scientists believe that the protein suspects in neurodegenerative diseases use prion-like templating to spread throughout the brain. However, catching these bad seeds in the act has been an enduring challenge. Now, researchers at Washington
RESEARCH NEWS 2014-10-10 Research News Not everyone who accumulates Aβ in the brain goes on to develop dementia. Could genetic factors influence how quickly amyloid starts to degrade learning and memory? In the October 7 Molecular Psychiatry online, scientists led by Colin Master
RESEARCH NEWS 2014-10-10 Research News Eli Lilly has put its weight behind AstraZeneca’s BACE1 inhibitor. On September 16, the two companies announced they will collaborate on the Phase 2/3 AMARANTH trial of AZD3293 (see AstraZeneca press release). AZD3293 recently completed Ph
RESEARCH NEWS 2014-10-10 Research News Researchers have linked genes for amyotrophic lateral sclerosis and Parkinson’s disease in the same pathway, a cellular mechanism to degrade decrepit mitochondria. Scientists already knew that the PD genes parkin and PTEN-induced putative ki
RESEARCH NEWS 2014-10-10 Research News Results of a Phase 2 trial for idalopirdine, also known as Lu AE58054, were formally published October 6 in Lancet Neurology. Developed by the pharmaceutical company Lundbeck, based in Copenhagen, Denmark, this antagonist of the serotonin 6
RESEARCH NEWS 2014-10-11 Research News Over and over in Alzheimer’s clinical trials, compounds have failed to live up to their preclinical prowess. In the October 6 JAMA Neurology, researchers led by Shauna Yuan at the University of California, San Diego, suggest that one problem
RESEARCH NEWS 2014-10-17 Research News Thanks to an enormous effort to collect and comingle data from 17 ALS clinical studies, researchers can now access thousands of patient records to understand the disease’s natural progression, hunt for biomarkers, and plan better therapeutic
CONFERENCE COVERAGE 2014-10-17 Conference Coverage Would-be parents from families carrying devastating genetic mutations face a formidable decision: Should they have children and risk passing on the disease? It is even more complicated when the at-risk parent doesn’t know his or her ge
