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CONFERENCE COVERAGE 2004-12-05 Conference Coverage Axonal Transport Larry Goldstein, of University of California, San Diego, laid out his hypothesis that defects in axonal transport could starve the nerve terminal of needed supplies and lead to synaptic dysfunction in AD, Huntington�
CONFERENCE COVERAGE 2004-12-05 Conference Coverage List of Final Recommendations 1. Make better mouse models. Create strains with only subtle overexpression under endogenous promoter and authentic spatiotemporal regulation, such as YAC. Recreate humanized APP rat unavailable from Cepha
CONFERENCE COVERAGE 2003-09-08 Conference Coverage Overview The first day of Enabling Technologies 2003 focused on the natural history of Alzheimer's disease, fundamental cell biology, and mechanisms of neurodegeneration. On the second day, workshop participants reviewed the curre
CONFERENCE COVERAGE 2003-09-08 Conference Coverage 1. Conduct mechanistic studies to determine what Ab oligomers do in the synaptic cleft: how do they affect calcium metabolism and synapse function when applied from outside to normal slices of brain tissue or when the oligomers are pro
RESEARCH NEWS 2014-09-19 Research News Twins who came to an ALS Clinic in Toronto were identical down to the repeats in their C9ORF72 genes, except one had amyotrophic lateral sclerosis and the other did not. The mismatch suggests environmental influences modified the twins’ risk
RESEARCH NEWS 2014-09-19 Research News Experts agree that reducing some medications may improve the quality of life for patients with advanced dementia by eliminating side effects and the discomfort of swallowing unneeded pills. Despite this, overmedication remains a significant
CONFERENCE COVERAGE 2002-08-06 Conference Coverage Introduction This report summarizes discussions at the second workshop on Enabling Technologies for Alzheimer's Disease (AD), held in August 2002 in Bar Harbor, Maine. Participants included academic and industry scientists from bo
CONFERENCE COVERAGE 2002-08-06 Conference Coverage A majority of investigators agree that AβPP processing, Aβgeneration, Aβ degradation, and Aβaggregation play a major role in Alzheimer's disease. There is a growing consensus on the potential importance of low-n oligomeric species
CONFERENCE COVERAGE 2002-08-06 Conference Coverage Lead discovery is hampered by the absence of good cell-based assays in which to screen libraries against AβPP secretases and other targets. One participant presented a new strategy for using fluorescent proteins in cell-based assays fo
CONFERENCE COVERAGE 2002-08-06 Conference Coverage A key controversy revolved around the value of available mouse models. Current Aβ models are only partial models of AD; they recapitulate amyloid deposition, gliosis around neuritic plaques, subtle synaptic changes and neuritic damage,
CONFERENCE COVERAGE 2002-08-06 Conference Coverage Recommendations: 1. Facilitate access to blood samples from people in prospective studies so that experimental biomarkers can be tested in stages prior to disease. Help develop standards for sample collection that preserve RNA and prot
CONFERENCE COVERAGE 2001-08-06 Conference Coverage In August 2001, a diverse group of academic and industry investigators from within and outside of Alzheimer's disease research participated in this workshop in Bar Harbor, Maine. The goal was to identify critical knowledge gaps th
CONFERENCE COVERAGE 2001-08-06 Conference Coverage Robert Balaban opened the discussion by observing that heart disease and AD research share certain characteristics, including a weak familial linkage, poor penetrance of some of the known risk factors, and a poor understanding of the i
CONFERENCE COVERAGE 2001-08-06 Conference Coverage Tim Clark began by laying out recommendations about the information infrastructure required if many groups want to be able to do collective experimentation, to share data, and to exploit automated pattern recognition in that shared dat
RESEARCH NEWS 2014-09-24 Research News The hippocampus contains some of the best-studied neural circuits in the brain. It also plays a crucial role in learning and memory, and it is compromised in people with Alzheimer’s disease. How well do neuroscientists know their favorite se
