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NEALS: Collaboration for a Cure to ALS

RESEARCH NEWS 2011-10-26 Research News Never mind raising a child. It takes a village to stage a high-power clinical trial for neurodegenerative disease. Or rather, make that a global network of dedicated doctors and scientists. In the field of amyotrophic lateral sclerosis (ALS) ...

Getting to Go: GAP-Net Sets Sight on Faster Start

CONFERENCE COVERAGE 2019-03-22 Conference Coverage In their grand project to hasten the start-up of therapy trials, the Global Alzheimer’s Platform trial network (GAP-Net) is looking to unclog procedural bottlenecks. Part 1 of this report of the GAP-Net Site Optimization conference, ...

Randall Bateman Wins Potamkin Prize

COMMUNITY NEWS 2019-03-22 Community News The 2019 Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases goes to Randall Bateman, Washington University, St. Louis. Bateman is being recognized for his work on the underlying biology of AD and for his commitment to ...

In Year Three, GAP Trial Network Is Starting to Hum

CONFERENCE COVERAGE 2019-03-21 Conference Coverage Outside the daffodils and forsythia were blooming, but the group assembled in Nashville, Tennessee, hardly took notice. At the GAP-Net Site Optimization Conference, held February 27–March 1, representatives of 61 academic and private ...

FDA Panel Rejects Neuronix Brain Stimulation Device

RESEARCH NEWS 2019-03-27 Research News An advisory panel appointed by the FDA was nearly unanimous in recommending yesterday that Yokneam, Israel-based Neuronix not be allowed to market its neuroAD Therapy System in the U.S. Approved for AD in Europe, Australia, and Israel, the ...

NIH Summit Sets Agenda for AD-Related Dementias

CONFERENCE COVERAGE 2019-03-22 Conference Coverage A busy hub of subcommittee meetings and brainstorming sessions, the Alzheimer's Disease-Related Dementias Summit 2019, held March 14–15 at the National Institutes of Health, Bethesda, Maryland, articulated research priorities for ...

TREM2: Diehard Microglial Supporter, Consequences Be DAMed

CONFERENCE COVERAGE 2018-07-13 Conference Coverage Like a dedicated mother doling out heaps of unconditional love, TREM2 supports microglial cells in all their pursuits, whether they help or hurt the brain. Trash clean-up, Aβ plaque containment, calling in blood cells for reinforcement ...

Turning Peripheral Stem Cells into Amyloid-Gobbling Brain Phagocytes

RESEARCH NEWS 2018-01-05 Research News For brain microglia struggling to keep amyloid plaques under control, help could be on the way. In a study published this week in PNAS, Richard Lerner and colleagues at The Scripps Research Institute in La Jolla, California, identify an ...

Results from IDEAS Study Published

RESEARCH NEWS 2019-04-03 Research News Results of the Imaging Dementia–Evidence for Amyloid Scanning study were published April 2 in JAMA. IDEAS tested if amyloid PET affected the management or outcomes of dementia care. As reported previously on Alzforum, physicians changed ...

Resetting Brain Rhythms Gives Working Memory a Brief Boost

RESEARCH NEWS 2019-04-10 Research News Groups of neurons fire in sync with each other across the brain when it performs a task; however, with age, they fall out of step. In the April 8 Nature Neuroscience, Robert Reinhart and John Nguyen of Boston University reported that out-of ...

Second Look at BAN2401 Data Still Positive, Despite Snafu

CONFERENCE COVERAGE 2018-11-02 Conference Coverage Researchers got a fuller view of the data coming out of the Phase 2b trial of the anti-Aβ BAN2401 antibody at the 11th Clinical Trials on Alzheimer Disease conference, which convened in Barcelona, Spain, from October 24–27. Eisai’s ...

Scientists Hunting Rare Alzheimer’s Mutations Eye Phospholipase D3

CONFERENCE COVERAGE 2013-08-14 Conference Coverage Having surveyed the genome for common variants associated with Alzheimer’s disease, geneticists are now turning the search lights on rare, hard-to-find mutations that may be even stronger risk factors. At the Alzheimer’s Association ...

The Power of Three: Genetic Trios Yield ALS Gene Candidates

RESEARCH NEWS 2013-05-29 Research News The May 26 Nature Neuroscience online debuts 25 new candidate genes for amyotrophic lateral sclerosis. Researchers found the genes by sequencing the exomes of patient-parent trios. Variations within the genes must have arisen de novo in each ...

At AD/PD Conference, New Alzheimer’s Genes Reinforce Known Pathways

CONFERENCE COVERAGE 2019-04-19 Conference Coverage Genome-wide association studies have turned up some 30 loci linked to Alzheimer’s, yet GWAS still left much of the disease’s heritability unexplained. To find the remaining genes, geneticists have turned to whole-genome and whole-exome ...

APP Upp: Mutation Nixes Six Amino Acids from Aβ, Spurs Aggregation

CONFERENCE COVERAGE 2019-04-20 Conference Coverage Thirty missense mutations in amyloid precursor protein  are known to cause autosomal-dominant Alzheimer’s disease. Now, scientists at Uppsala University, Sweden, have identified a deletion in the APP gene that does the same thing. At ...

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