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Diabetes and Depression: A Dementia-Causing Duo

RESEARCH NEWS 2013-08-23 Research News While people with type 2 diabetes are at greater risk for Alzheimer’s disease, predicting who among them will go on to develop dementia remains difficult. Two new studies offer some clues. In the inaugural Lancet Diabetes & Endocrinology ...

Rusty Unleashed: Forget Disease Modification, Go for Big Effect

CONFERENCE COVERAGE 2014-12-13 Conference Coverage In current affairs, sometimes the recently retired general gives the best advice. He speaks from experience and from the heart, no longer toeing the party line. Researchers at the Clinical Trials in Alzheimer’s Disease (CTAD) ...

Rare but Severe Side Effects Sideline Some Phase 3 Encenicline Trials

RESEARCH NEWS 2015-09-16 Research News Reports of severe gastrointestinal events in some participants led the Food and Drug Administration to put four of six Phase 3 trials of encenicline on hold. FORUM Pharmaceuticals of Waltham, Massachusetts, is developing the drug—an α7 ...

Type 2 Diabetes and Neurodegeneration—The Plot Caramelizes

RESEARCH NEWS 2009-01-29 Research News Two new papers add to growing evidence linking diabetes and neurodegenerative disease, including dementia and Parkinsonism. In the January 12 Archives of Neurology, researchers led by Suzanne Craft at the VA Puget Sound and University of ...

Eibsee: Antibody Binding Crystal Clear; New Vaccine in the Mix

CONFERENCE COVERAGE 2009-01-07 Conference Coverage At the 8th annual Eibsee Meeting on Cellular Mechanisms of Alzheimer’s Disease, held October 29 to November 1 in Germany, two speakers presented advances in the development of immunotherapies for AD. Despite widely reported hiccups in ...

Beyond the Nucleus: TDP-43 Sticks Together, For Better or Worse

CONFERENCE COVERAGE 2018-12-01 Conference Coverage Similar to a newborn human, nascent RNA transcripts need a lot of coddling before they realize their purpose in life (that is, translation into protein). It takes a village of RNA-binding proteins to accomplish this. They see to the ...

RNA-Binding Protein Linked to Ataxin-2 toxicity

RESEARCH NEWS 2018-09-28 Research News An RNA-binding protein never before linked to neurodegeneration may conspire with ataxin-2 to decimate the neuronal transcriptome. According to a September 7 paper in Nature Communications, the cytoplasmic Staufen1 accrues in neurons when ...

Dipeptide Repeats May Hobble Ribosomes in C9ORF72-FTD Patient Brain

RESEARCH NEWS 2018-06-09 Research News How do hexanucleotide expansions in the C9ORF72 gene cause amyotrophic lateral sclerosis and frontotemporal dementia? According to a study published May 16 in Life Science Alliance, a new open-access journal run by EMBO Press, Rockefeller ...

Microglia Kick Off Inflammatory Chain Reaction

RESEARCH NEWS 2015-03-06 Research News Picture a bit of bacterial membrane floating about the brain. When a patrolling microglia cell notices that, it prods neighboring microglia to prick up their ears, too. Researchers now report that their clarion call consists of a protein ...

Meeting Explores Complex Biology of BACE Regulation

CONFERENCE COVERAGE 2013-12-26 Conference Coverage Beta-secretase continues to be an attractive target for those looking for the next Alzheimer's disease therapy. Merck is starting a large trial of its BACE inhibitor MK-8931  in prodromal AD (see Dec 2013 news story), and almost a ...

BACE—Substrates, Functions, Developmental Phenotypes

CONFERENCE COVERAGE 2013-12-11 Conference Coverage BACE1 is the major β-secretase for amyloid precursor protein, making it a prime target for drug developers. However, because this protease cleaves many substrates, scientists worry about adverse effects of BACE inhibition (see part one ...

Profilin-1 Links Cytoskeleton and RNA Aggregation in ALS

CONFERENCE COVERAGE 2013-11-20 Conference Coverage Several proteins linked to amyotrophic lateral sclerosis and frontotemporal dementia show up in stress granules. These natural RNA-protein accumulations protect essential RNAs in times of cellular strife, but cause trouble if they fail ...

One, Two, Three…Four? Peripherin Jams With Neurofilament in Quartet

RESEARCH NEWS 2012-06-23 Research News It is a well-established trio: the light, medium, and heavy chains of neurofilament assemble together to form axonal girders. But in the June 22 Journal of Neuroscience, researchers from the Nathan Kline Institute in Orangeburg, New York, ...

The Many Faces of LRRK2

CONFERENCE COVERAGE 2012-10-24 Conference Coverage Polymorphisms in the gene for leucine-rich repeat kinase 2 (LRRK2) confer risk for both familial and sporadic forms of Parkinson’s disease (PD). LRRK2 substrates have been hard to pin down, and the kinase's role in pathogenesis ...

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