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Large Majority of Football Players in BU Brain Bank Have CTE

RESEARCH NEWS 2017-07-25 Research News In the largest autopsy study to date of American football players, 177, or 87 percent, of the brains of 202 former players who had donated them for research showed evidence of chronic traumatic encephalopathy (CTE), a neurodegenerative ...

Consortium to Seek Biomarkers for Vascular Cognitive Impairment

COMMUNITY NEWS 2017-03-03 Community News Even though vascular dementia is the second most common form of dementia and the most frequent comorbidity with Alzheimer’s disease, researchers still have no reliable way to detect and track it. To fill this gap, the National Institutes of ...

Monogenetic and Sporadic Alzheimer’s Disease: Same or Different?

CONFERENCE COVERAGE 2016-08-17 Conference Coverage Part 4 of a five-part report. Asking whether autosomal-dominant Alzheimer’s disease is essentially the same disease as sporadic late-onset AD is a sure-fire way to spark debate among researchers. This debate has raged since the 1970s, ...

AD-Related Dementias Summit 2016: Progress, Aims, Dollars

CONFERENCE COVERAGE 2016-04-20 Conference Coverage It may not be obvious from its name, but the National Alzheimer’s Project Act (NAPA) covers related dementias, too—those that go beyond plaques and tangles to involve α-synuclein, TDP-43, and vascular pathologies. The Lewy body, ...

Preclinical Research Offers New Angles on Immunotherapy

CONFERENCE COVERAGE 2015-11-27 Conference Coverage Despite early disappointments, drug developers have bought into immunotherapy for Alzheimer’s disease, banking on a handful of antibodies and active vaccines currently in Phase 2/3 trials and others in Phase 1. As evident from this ...

Neurofilament Light Chain: A Useful Marker for AD Progression?

RESEARCH NEWS 2015-11-06 Research News Researchers studying Alzheimer’s disease often focus on the death of neurons in gray-matter regions of the brain, but large white-matter tracts also deteriorate. According to a study in the November 2 JAMA Neurology, debris from these ...

VasCog 2015—Highlights of a Conference

CONFERENCE COVERAGE 2015-10-20 Conference Coverage This meeting report was contributed to Alzforum by Donna Wilcock, University of Kentucky, Lexington. The International Society of Vascular Behavioral and Cognitive Disorders, aka VasCog, held its annual meeting in the beautiful city of ...

Better Models Weigh In on AD-Diabetes Link

RESEARCH NEWS 2010-03-19 Research News Two new animal models may help researchers clarify the link between diabetes and Alzheimer disease (AD). Researchers in Japan have crossed an AD mouse (APP23) with two types of diabetic cousins, the leptin-deficient obese mouse (ob/ob) and ...

London: What, No Argument? Speakers Agree on Trials for Familial AD

CONFERENCE COVERAGE 2010-11-17 Conference Coverage Part 1 of this series highlighted the main points of discussion at an 8 November 2010 meeting held at the European Medicines Agency (EMA) in London. Called “Expert meeting in familial neurodegenerative disorders. Developing medicinal ...

Stockholm: Science Smorgasboard at Biannual Meeting

CONFERENCE COVERAGE 2012-06-07 Conference Coverage The 12th International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy took place May 9-12 in the Swedish Capital. Organized by Agneta Nordberg, Karolinska Institute, Stockholm, and Ezio Giacobini and Gabriel Gold from ...

In Big Picture, Familial AD’s Biomarker Data Resemble LOAD

CONFERENCE COVERAGE 2012-08-09 Conference Coverage Researchers with eyes peeled toward prodromal Alzheimer’s disease probably see this diagram in their sleep—the one where the field’s five most validated markers trace their poignant path from normal cognition to fully developed AD. Two ...

Diabetes and Depression: A Dementia-Causing Duo

RESEARCH NEWS 2013-08-23 Research News While people with type 2 diabetes are at greater risk for Alzheimer’s disease, predicting who among them will go on to develop dementia remains difficult. Two new studies offer some clues. In the inaugural Lancet Diabetes & Endocrinology ...

Rusty Unleashed: Forget Disease Modification, Go for Big Effect

CONFERENCE COVERAGE 2014-12-13 Conference Coverage In current affairs, sometimes the recently retired general gives the best advice. He speaks from experience and from the heart, no longer toeing the party line. Researchers at the Clinical Trials in Alzheimer’s Disease (CTAD) ...

Rare but Severe Side Effects Sideline Some Phase 3 Encenicline Trials

RESEARCH NEWS 2015-09-16 Research News Reports of severe gastrointestinal events in some participants led the Food and Drug Administration to put four of six Phase 3 trials of encenicline on hold. FORUM Pharmaceuticals of Waltham, Massachusetts, is developing the drug—an α7 ...

Type 2 Diabetes and Neurodegeneration—The Plot Caramelizes

RESEARCH NEWS 2009-01-29 Research News Two new papers add to growing evidence linking diabetes and neurodegenerative disease, including dementia and Parkinsonism. In the January 12 Archives of Neurology, researchers led by Suzanne Craft at the VA Puget Sound and University of ...

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