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C9ORF72 Repeats Expand into New Disorders—Cause, or Coincidence?

RESEARCH NEWS 2014-04-25 Research News Long repeat sequences in the C9ORF72 gene have cropped up in cases of multiple system atrophy (MSA) and depressive pseudodementia, according to two new case studies. The findings, published in JAMA Neurology on April 14 and 21, respectively,

Does Dendritic Tau Promote Plasticity?

RESEARCH NEWS 2014-04-25 Research News In Alzheimer’s brains, the axonal protein tau strays into dendritic spines and stirs up trouble at synapses. Researchers have called this a mislocalization, but a paper in the April 23 Journal of Neuroscience challenges this view, suggesting

Muscle-Boosting Therapy Fails in Phase 2 Trial for ALS

RESEARCH NEWS 2014-04-26 Research News The experimental muscle-stimulating drug Tirasemtiv was unable to improve amyotrophic lateral sclerosis (ALS) symptoms in a Phase 2 clinical trial, according to top-line data. Announced April 25 by the drug’s developer, South San Francisco-b

Does PET Tracer Reveal Severity of Parkinson's?

RESEARCH NEWS 2014-04-26 Research News In order to gauge the effectiveness of disease-modifying therapies for Parkinson’s, researchers are looking for a biomarker that measures how far a person’s disease has advanced. In the April 21 JAMA Neurology, scientists led by Kun-Ju Lin a

18 Years After Dolly, First Adult Human Cells Cloned

RESEARCH NEWS 2014-04-28 Research News It appears that scientists have finally succeeded in cloning adult human cells, a goal that has tantalized the field since the first successful cloning of an adult mammal, Dolly the sheep, in 1996. Two independent papers report the generatio

Mesulam Awarded Potamkin Prize

COMMUNITY NEWS 2014-05-01 Community News Marek-Marsel Mesulam of Northwestern University in Chicago wins this year’s Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases. Supported by philanthropic donations from the Potamkin family of Colorado, Philadelphia, a

Fluid Markers and Imaging Back Idea of Breached Blood-Brain Barrier

CONFERENCE COVERAGE 2014-05-02 Conference Coverage Besides hypertension (see part one  of this series), a second source of neurovascular damage in the aging human brain took center stage at the inaugural Zilkha Symposium on Alzheimer’s Disease and Related Disorders, held April 4 at the

Alzheimer's GWAS Hits Reflected in Monocyte Gene Expression

RESEARCH NEWS 2014-05-02 Research News Genome-wide association studies reveal whether genetic variants influence susceptibility to disease, but say nothing about how they do it. In Alzheimer's, for example, most GWAS hits fall in non-coding regions of the genome, suggesting

Do Frontoparietal Regions Shrink First in Preclinical Alzheimer’s?

RESEARCH NEWS 2014-05-02 Research News Hippocampal atrophy characterizes symptomatic Alzheimer’s disease, but a study in the April 28 JAMA Neurology makes the case that degeneration actually begins in the frontoparietal cortex. Researchers led by Niklas Mattsson at the University

Three’s Company: Florbetaben Approved, Excludes AD Diagnosis

RESEARCH NEWS 2014-05-02 Research News A third amyloid imaging agent has joined the ranks of those approved for clinical use. Piramal Imaging’s PET tracer florbetaben, now rechristened Neuraceq, got the nod from the European Medicines Agency on February 20, and from the U.S. Food

Glymphatic Flow, Sleep, microRNA Are Frontiers in Alzheimer’s Research

CONFERENCE COVERAGE 2014-05-06 Conference Coverage The neurovascular focus of the first Zilkha Symposium on Alzheimer’s Disease and Related Disorders, held April 4 in Los Angeles, started off with talks on the blood-brain barrier and midlife hypertension (parts one and two of this seri

Longevity Gene Boosts Brainpower, Even in the Young

RESEARCH NEWS 2014-05-09 Research News Named after the Greek goddess who spins the thread of life, the klotho gene not only extends lifespan in mice and humans but also bestows greater intelligence, according to a paper published open-access in Cell Reports on May 8. Scientists l

Out With the Old, In With the New—Neurogenesis Refreshes Memories

RESEARCH NEWS 2014-05-13 Research News Fledgling neurons in the hippocampus are thought to play a major role in laying down new memories. Now, a study suggests that neurogenesis also makes us quickly forget. In the May 9 Science, researchers led by Sheena Josselyn and Paul Frankl

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