Islands of Tau Coat and Protect Cytoskeleton

RESEARCH NEWS 2019-09-06 Research News Two papers in the September 2 Nature Cell Biology present complementary evidence that tau condenses into a patchwork of rafts that coat microtubules. These patches share some properties with phase-separated liquid droplets of tau that have ...

Are Microglia Plaque Factories?

RESEARCH NEWS 2019-09-04 Research News Are microglia the masterminds of amyloid plaque formation? In the August 21 Nature Communications, researchers led by Kim Green at the University of California, Irvine, suggest these cells seed amyloid deposits. In a mouse model of ...

Hello Mitochondriomics: Tagging Method Identifies Different Subtypes

RESEARCH NEWS 2019-09-11 Research News Mitochondria may be the universal powerhouses of eukaryotic cells, but there is more to these organelles than just ATP production. According to a paper in the September 9 Nature Neuroscience, mouse mitochondria express distinct subsets of ...

Tiny Brain Structure Plays Big Role in Memory

RESEARCH NEWS 2019-09-13 Research News The humble locus coeruleus, a minute speck of tissue nestled deep in the brain stem, has received relatively scant attention in studies of cognitive decline. Now, data published September 9 in Nature Human Behavior add to a recent spate of ...

Among AD Mutations, Only ApoE4 Seems to Hobble Microglia

RESEARCH NEWS 2019-09-14 Research News New research adds to the evidence that ApoE regulates microglial health and activity. Researchers led by Tarja Malm at the University of Eastern Finland, Kuopio, examined how several Alzheimer’s risk factors affect microglia generated from ...

“Runner Plasma” Jogs Neurogenesis, Quells Neuroinflammation in Mice

RESEARCH NEWS 2019-09-27 Research News Regular exercise infuses the blood with factors that benefit the brain, according to a manuscript posted on the bioRχiv preprint server on September 19. Researchers led by Tony Wyss-Coray of Stanford University reported that plasma taken ...

Frontal Metabolic Patterns Mark Behavioral Subtype of AD

RESEARCH NEWS 2019-09-28 Research News In a small percentage of people with Alzheimer’s disease, behavioral changes early on—such as a disregard for social norms or loss of empathy—can lead physicians to mistakenly diagnose behavioral variant frontotemporal dementia (bvFTD). How ...

Adenosine Receptors Rev Up Immune Response, Memory Loss, in Tau Model

RESEARCH NEWS 2019-10-09 Research News Adenosine receptors may hasten inflammatory responses to tau pathology, according to a paper published this month in Brain. Researchers led by David Blum of the University of Lille, France, reported that in a mouse model of tauopathy, the ...

In Tauopathy, ApoE Destroys Neurons Via Microglia

RESEARCH NEWS 2019-10-17 Research News ApoE4 delivers a blow to neurons in mouse models of tauopathy but, according to a paper published October 10 in the Journal of Experimental Medicine, it only does so if mice have their microglia. Researchers led by David Holtzman at ...

With a Shot of Adrenaline, Amyloid-β Sparks Tau Cascade

RESEARCH NEWS 2020-01-23 Research News Aβ oligomers may set off tau phosphorylation by hijacking the adrenergic system, according to a study published January 15 in Science Translational Medicine. Researchers led by Qin Wang at the University of Alabama in Birmingham reported ...

Connectivity, Not Proximity, Predicts Tau Spread

RESEARCH NEWS 2020-01-24 Research News The idea that tau pathology creeps through the brain via neural circuitry may have gained its strongest support yet from a study published January 17 in Nature Communications. Drawing on longitudinal tau PET imaging data from ADNI and ...

Stress-Associated Protein Modulates γ-Secretase to Make More Aβ

RESEARCH NEWS 2020-03-21 Research News In the March 17 Science Signaling, researchers led by Yong-Keun Jung at Seoul National University, South Korea, reported a new modulator of γ-secretase that appears to preferentially affect cleavage of amyloid precursor protein. Stress ...

Attack of the Clones? Memory CD8+ T Cells Stalk the AD, PD Brain

RESEARCH NEWS 2020-01-14 Research News As if the neurodegenerative brain didn’t have enough troubles, a study published in Nature on January 8 reports that it may be swarming with highly trained cellular henchmen. Researchers led by Tony Wyss-Coray at Stanford University found ...

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