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COMMUNITY NEWS 2017-05-30 Community News On May 20, at age 93, Robert Davis Terry passed away in Carlsbad, California. Terry had been in declining health for some time, according to Michael Shelanski of Columbia University, New York, an early trainee and longtime friend. During Sh
RESEARCH NEWS 2018-02-02 Research News For decades, scientists have yearned for a blood test that can tell who accumulates amyloid in the brain. A simple blood draw would help fill clinical trials much more quickly and cheaply than PET scans or lumbar punctures. The dream looks s
RESEARCH NEWS 2018-06-29 Research News Aβ is generally considered a rogue peptide, but recent research is building a case that it may have a secret identity as an antimicrobial superhero. Confronted with an unwelcome bacteria or fungus, the peptide quickly forms amyloid fibrils t
RESEARCH NEWS 2020-02-10 Research News DIAN participants and investigators today are grappling with difficult news. A topline analysis of the first Phase 2/3 clinical trial that the DIAN-TU trials platform mounted for carriers of dominantly inherited Alzheimer’s disease mutations
RESEARCH NEWS 2021-04-30 Research News Is idiopathic Alzheimer’s more than one disease? And is there even such a thing as “typical” AD? Given the heterogeneity in clinical presentation and pathology, some scientists have suggested as much for years, but with the exception of cert
COMMUNITY NEWS 2019-09-17 Community News Researchers are mourning the untimely passing of a pioneer in the field of protein chemistry. Christopher Dobson succumbed to cancer on September 8, a month shy of his 70th birthday. Dobson, who had worked at the University of Cambridge sin
RESEARCH NEWS 2020-09-18 Research News Under rare circumstances, Aβ seeds can be transferred to people during medical procedures. Researchers have turned up a few cases of tissue transplants or hormones from cadavers triggering amyloidosis in the brains or blood vessels of recipi
RESEARCH NEWS 2023-09-06 Research News Alois Alzheimer reported lipid-filled glia surrounding amyloid plaques in the AD brain. But how and why they appear remains elusive. Now, two bioRxiv preprints blame Aβ. In one, posted June 6, scientists led by Gaurav Chopra of Purdue Univer
COMMUNITY NEWS 2013-03-29 Community News In light of recent failures in high-profile Alzheimer’s disease clinical trials, scientists have turned their attention with increasing urgency toward testing therapies in early-stage patients who have underlying brain pathology but little
RESEARCH NEWS 2015-07-24 Research News Tau protein undergoes a bewildering variety of modifications, from phosphorylations and acetylations to the addition of sugar groups. What roles do these modifications play, and which most likely associate with disease? To tackle this questi
RESEARCH NEWS 2017-11-11 Research News Could Aβ from the blood contribute to Alzheimer’s disease? In the October 31 Molecular Psychiatry, researchers led by Yan-Jiang Wang at Daping Hospital, Third Military Medical University in Chongqing, China, and Weihong Song at the Universit
RESEARCH NEWS 2018-06-12 Research News Eli Lilly and AstraZeneca today announced that they will end two ongoing Phase 3 trials of lanabecestat, a small-molecule BACE inhibitor the two companies have been developing jointly since 2014. According to the program’s independent data m
RESEARCH NEWS 2019-05-29 Research News When a virus enters a biological fluid of a host—blood, lung, or cerebrospinal fluid—it becomes ensheathed by a unique set of proteins from its new environment. The proteins that make up the sheath differ depending on the fluid and on the ty
RESEARCH NEWS 2021-06-10 Research News Small snippets of cell membranes that pinch off the neuronal surface are getting swept up in a rather large controversy. Some of these extracellular vesicles wend their way into the cerebrospinal fluid and even plasma, from where they can be
RESEARCH NEWS 2021-10-01 Research News A rare APOE3 variant, dubbed APOE3-Jacksonville, drastically reduces a person's risk of developing Alzheimer’s disease. How does it protect the brain? Primarily by reducing ApoE self-aggregation, according to scientists led by Guojun Bu
