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To Monitor Neurons, Microglia Talk With the Boss, aka the Soma

RESEARCH NEWS 2019-12-13 Research News To ensure homeostasis in the brain, microglia are constantly feeling about with their finger-like processes, making sure that all is well, or sensing problems and rearing up to help. A study in today’s Science suggests that these processes ...

Does Tau Kill Neurons by Way of Necroptosis?

RESEARCH NEWS 2020-01-15 Research News How do neurons die in Alzheimer’s disease? Perhaps by necroptosis, a form of programmed cell death triggered by inflammation. In the December Acta Neuropathologica, researchers led by Dietmar Thal, Bart De Strooper, and Sriram Balusu at KU ...

Newly Identified Microglia Contain Lipid Droplets, Harm Brain

RESEARCH NEWS 2019-08-23 Research News Microglia in the brain assume a dizzying array of states. Now researchers led by Tony Wyss-Coray at Stanford University, Palo Alto, California, describe a new one: lipid droplet-accumulating microglia (LAM). These lipid-stuffed cells ...

Picking Through the Rubble, Field Tries to Salvage BACE Inhibitors

CONFERENCE COVERAGE 2019-12-20 Conference Coverage Anti-amyloid antibodies are at long last showing promise for treating Alzheimer’s disease, but for long-term use, researchers are seeking cheaper and easier options than monthly infusions. They want that elusive once-a-day pill. BACE ...

Cell-Specific Enhancer Atlas Centers AD Risk in Microglia. Again.

RESEARCH NEWS 2019-11-16 Research News Most GWAS hits lie in noncoding regions of the genome, making it hard to figure out what they do. To address this, researchers led by Christopher Glass at the University of California, San Diego, analyzed epigenetic data from purified ...

AD Genetic Risk Tied to Changes in Microglial Gene Expression

RESEARCH NEWS 2019-08-09 Research News Geneticists have found dozens of loci that associate with Alzheimer’s disease, but the functional variants and even the genes that underlie these associations often remain elusive. Now, researchers led by Alison Goate and Edoardo Marcora at ...

Mutations in Epigenetic Gene Linked to Neurodegeneration

RESEARCH NEWS 2020-05-01 Research News Rare but powerful gene variants help scientists understand how disease develops, but they are hard to find. By pooling data on people with different early onset dementias to get cohorts of a workable size, researchers pulled out an ...

Alzheimer’s Gene BIN1 Promotes Synaptic Transmission

RESEARCH NEWS 2020-03-18 Research News BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and microglial function. Now, in the March 10 ...

Parsing Local and Distal Aβ Shows Links to Metabolism, Cognition

RESEARCH NEWS 2019-06-14 Research News For decades, researchers have wondered why Aβ deposits in the brain correlate poorly with local neural activity and cognition. Perhaps the correlation was not that weak, after all. A study in the June 4 Nature Communications suggests that it ...

Aβ Dimers Block Glutamate Uptake, Fire Up Synapses

RESEARCH NEWS 2019-08-09 Research News Soluble Aβ sends neurons into a hyperactive frenzy, but scientists don’t know why. New evidence suggests that the peptide causes the excitatory neurotransmitter glutamate to build up in synapses, making neurons hyperactive. In the August 9 ...

ApoE4 Glia Bungle Lipid Processing, Mess with the Matrisome

RESEARCH NEWS 2019-08-16 Research News ApoE4 predisposes people to Alzheimer’s disease by modulating astrocytes and microglia, suggest researchers led by Julia TCW and Alison Goate at the Icahn School of Medicine at Mount Sinai, New York. In a preprint on bioRχiv, the researchers ...

Spatial Transcriptomics Uncovers Coordinated Cell Responses to Amyloid

RESEARCH NEWS 2019-08-23 Research News With single-cell resolution, scientists now have a good idea of what amyloid plaques do to nearby cells in the brains of mice. Scientists led by Bart De Strooper, KU Leuven, Belgium, used a combination of spatial transcriptomics and in situ ...

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