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RESEARCH NEWS 2023-03-10 Research News A potential treatment for Alzheimer’s disease relies on 40 Hz light or sound to entrain gamma rhythms in the brain. This intervention, pioneered by Li-Huei Tsai and colleagues at Massachusetts Institute of Technology, Boston, and repeated by
CONFERENCE COVERAGE 2021-03-19 Conference Coverage It has been clear for a while that anti-amyloid antibodies can sweep plaque from the brain, but until now the question of whether this slows cognitive decline has remained hotly contended. Despite some positive signals from four such a
RESEARCH NEWS 2005-01-13 Research News In efforts to interfere with Aβ peptide production, most of the attention has been lavished on the β- and γ-secretase enzymes. Could, however, their neglected cousin α-secretase prove to be the better target? In an article published January
COMMUNITY NEWS 2016-11-30 Community News Chad Dickey, associate professor at the Byrd Alzheimer’s Institute at the University of South Florida, Tampa, passed away last Friday, November 25, after a short bout with cancer. “Chad was an incredible scientist who was just starting to s
COMMUNITY NEWS 2023-05-12 Community News Mary Jo LaDu, or MJ, as she was affectionately known among her many close friends and colleagues, passed away on March 28 after a prolonged illness. On May 8, scientists and friends gathered in person and online for a memorial service, many
RESEARCH NEWS 2023-09-08 Research News In the blood, lipoproteins ferry cholesterol and other lipids to cells throughout the body. In the cerebrospinal fluid, they may do the same, but because they are 200-fold more dilute there, scientists know little about them. Now, John Melch
RESEARCH NEWS 2023-01-10 Research News Time to rewrite the brain anatomy textbook? In addition to the outermost dura, middle arachnoid, and innermost pia membranes surrounding the brain, researchers led by Kjeld Møllgård, University of Copenhagen, and Maiken Nedergaard, Universit
RESEARCH NEWS 2016-07-08 Research News Updated July 13 to correct apolipoprotein nomenclature. By the time late-onset Alzheimer’s disease emerges from the shadows, the tangled web of biological intrigue that caused the disease is nearly impossible to tease apart. Now, in a study
RESEARCH NEWS 2018-02-14 Research News A year after announcing an early end to the EPOCH trial of the BACE inhibitor verubecestat in mild to moderate Alzheimer’s disease, Merck pulled the plug on the APECS study, a trial of prodromal AD patients. In a February 13 press releas
RESEARCH NEWS 2022-01-06 Research News While clinicians commonly gauge a person's Alzheimer’s disease risk by the amount of Aβ42 in their cerebrospinal fluid, it is unclear exactly what shorter peptide fragments mean in this regard. According to researchers led by Oskar Hans
RESEARCH NEWS 2021-09-03 Research News In the Alzheimer’s cascade hypothesis, plaques unleash tangles; alas, where neuroinflammation fits in has been hazy. Now, the first study to combine imaging of microglial activation with amyloid and tau PET in the human brain places neuroinf
RESEARCH NEWS 2005-10-02 Research News The use of gene expression profiling to characterize Alzheimer disease pathology has, unsurprisingly, focused on changes in brain tissue (see ARF related news story), but the search for biomarkers that might allow early diagnosis is moving o
RESEARCH NEWS 2004-07-05 Research News The results of the AD2000 study of donepezil (Aricept) in Alzheimer's—published in the June 26 Lancet—made a big splash in the media pond. While confirming previous findings of modest benefits on certain tests, the study authors challen
RESEARCH NEWS 2015-10-16 Research News Could infectious agents that enter the brain contribute in some way to neurodegenerative disease? This idea has been fermenting in recent years, and new data from researchers led by Luis Carrasco at the Autonomous University of Madrid add fu
RESEARCH NEWS 2016-09-22 Research News A paper in the September 21 Journal of Neuroscience suggests that two prominent phenotypes considered relevant to Alzheimer’s disease are artifacts caused by overexpression of the amyloid precursor protein (APP). Scientists led by Takaomi Sa
