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San Diego: Oligomers Live Up to Bad Reputation, Part 1

CONFERENCE COVERAGE 2007-11-16 Conference Coverage Over the past decade, researchers have shifted away from a literal interpretation of Alois Alzheimer’s groundbreaking discovery of plaques and tangles as the likely cause of Alzheimer disease. After years of argument—mostly in the ...

Breakthrough or False Hope? Etanercept Case Report Draws Scrutiny

RESEARCH NEWS 2008-01-21 Research News Can an FDA-approved arthritis drug double as a therapy for Alzheimer disease? Claiming it did in a patient, a case report published in the January 9 Journal of Neuroinflammation generated a wave of media attention that splashed across ...

Target BACE: Better Than Ever?

RESEARCH NEWS 2004-01-09 Research News Also see Q&A below with Masuo Ohno, Robert Vassar, and John Disterhoft. In yesterday’s Neuron, researchers presented fresh in-vivo support for the amyloid hypothesis, and they bolster the status of the APP protease BACE as the current ...

Antibodies Stop Toxic Tau in Its Extracellular Tracks

RESEARCH NEWS 2013-09-26 Research News Like the police boot that keeps your car off the road, certain antibodies can stop pathological tau in its tracks and prevent it from infiltrating neurons, according to a paper in today’s Neuron online. Scientists led by joint senior authors ...

Mistakes Prompt Retraction of Controversial Paper, and Publication Ban

RESEARCH NEWS 2015-03-05 Research News On February 25, the Journal of Neuroscience quietly posted on its website  its retraction of a 2011 paper that questioned the existence of Aβ aggregates inside neurons. In a terse statement, the journal, a publication of the Society for ...

Brexit Could Threaten Neurodegenerative Disease Research in Europe

COMMUNITY NEWS 2016-07-08 Community News The decision by the people of Great Britain to leave the European Union not only left political chaos in its wake, but also roiled neuroscientists across the United Kingdom. Researchers there fret that the decision will cut them off from EU ...

U.S. Study Says Lithium in Tap Water Does Not Fend Off Dementia

RESEARCH NEWS 2018-05-24 Research News Lithium, used widely to treat bipolar disorder, does double duty as a neuroprotective and neurotrophic agent. Low levels of lithium, found naturally in drinking water, seem to ward off psychiatric disease, but whether they do the same for ...

CryoEM γ-Secretase Structures Nail APP, Notch Binding

RESEARCH NEWS 2019-01-11 Research News Targeting the γ-secretase protease to prevent Alzheimer’s disease would require surgical precision to shut down Aβ42 production while allowing the non-pathogenic processing of amyloid precursor protein (APP) and other important substrates to ...

Closing the Book on NSAIDs for Alzheimer’s Prevention

RESEARCH NEWS 2019-04-12 Research News Epidemiological data suggest that non-steroidal anti-inflammatory drugs (NSAIDs) stave off dementia, but multiple clinical trials have failed to bear that out. Now, the most recent and, the authors say, final effort has come up short. In the ...

Lithium Hinders Aβ Generation, Buffing Up GSK as Drug Target

RESEARCH NEWS 2003-05-22 Research News The widely used psychiatric drug lithium, and other agents that inhibit glycogen synthase kinase-3 (GSK3), have been mentioned as possible Alzheimer's disease therapies for some time, primarily because GSK3 is one of several kinases ...

Atorvastatin, Vaccine Trial Data Published

RESEARCH NEWS 2005-05-13 Research News A mixed bag of epidemiologic studies alternatively hold up and knock down the promise that widely prescribed cholesterol-lowering statin drugs might offer some protection against Alzheimer disease progression (see ARF related news story). ...

Love a Good Fight? Check Out Brouhaha Over Amyloid Imaging

COMMUNITY NEWS 2012-02-02 Community News See Q&A With Bengt Långström The ability to visualize fibrillar Aβ deposits in the brains of living people has been hailed as a breakthrough for Alzheimer’s disease research and differential diagnosis. Now, as the first of a suite of ...

Presenilins Open Escape Hatch for ER Calcium

RESEARCH NEWS 2006-09-09 Research News A paper out today in Cell proposes a novel role for presenilins in calcium signaling—that of an ion channel. The work, from Ilya Bezprozvanny and colleagues at the University of Texas Medical Center at Dallas, shows that presenilins appear ...

APP Double Dose Causes Early Onset AD

RESEARCH NEWS 2005-12-20 Research News For the first time, researchers have identified duplications of the amyloid precursor protein (APP) gene locus as the cause of early onset Alzheimer disease in five families. The findings, from the laboratory of Dominique Campion of INSERM ...

Chicago: Out of the Blue—A Tau-based Treatment for AD?

CONFERENCE COVERAGE 2008-08-07 Conference Coverage Of all clinical trials reported at the International Conference on Alzheimer’s Disease (ICAD) held 26-31 July in Chicago, one targeting the protein tau was the therapy du jour, both in terms of buzz among scientists and media coverage. ...

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