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Herpes Simplex Virus Triggers Amyloidosis in 3D Neural Cultures

RESEARCH NEWS 2020-05-08 Research News Looking for a way to model the human brain in a dish? Consider using a gel-filled silk sponge as a three-dimensional scaffold to mimic the vaunted organ’s architecture. That, at least, is the approach published by David Kaplan at Tufts ...

Mouse Brain Mapped in 3D, at High Resolution

RESEARCH NEWS 2020-05-13 Research News Behold the mouse brain, in glorious new detail. In the May 14 Cell, researchers led by Julie Harris and Lydia Ng at the Allen Institute for Brain Science in Seattle debut the third iteration of the Allen Mouse Brain atlas. Called the Common ...

Massive Proteomics Studies Peg Glial Metabolism, Myelination, to AD

RESEARCH NEWS 2020-05-23 Research News RNA sequencing studies of postmortem human brain samples have generated massive datasets implicating all manner of biological functions in Alzheimer’s disease. But how do these findings translate to proteins—where the biological rubber meets ...

New Astrocyte Marker Allows Purification from Mixed Cultures

RESEARCH NEWS 2020-06-05 Research News Astrocytes have been implicated in Alzheimer’s and other neurodegenerative diseases, but these beautiful, star-shaped cells are notoriously difficult to study. Animal models are little help, because their astrocytes are quite different from ...

Alzheimer’s Research Restarts, Cautiously

COMMUNITY NEWS 2020-06-23 Community News Part 1 of 2 Three months after it shuddered to a halt to contain coronavirus, Alzheimer’s research is powering up again. How did it weather the shutdown? Some three dozen researchers around the world told Alzforum how the pandemic has cost ...

TMEM106B Variants Regulate Gene Modules, TDP-43 Pathology

RESEARCH NEWS 2020-06-12 Research News Just as birds of a feather flock together, genes involved in common biological pathways often soar and fall in unison, at least when it comes to their expression. If that is so, then shouldn’t a genetic variant that affects one of those co ...

Does Alzheimer’s Start in the Heart of the Cholinergic System?

CONFERENCE COVERAGE 2020-04-16 Conference Coverage Three the approved drugs for Alzheimer’s disease attempt to boost the brain’s supply of acetylcholine, a critical neurotransmitter for cognition that wanes in people with the disease. But might crumbling of the brain’s cholinergic ...

Flortaucipir Autopsy Study Published

RESEARCH NEWS 2020-05-02 Research News Results from a large autopsy validation study suggest that flortaucipir PET can help clinicians diagnose late-stage Alzheimer’s disease. In the April 27 JAMA Neurology, researchers led by Adam Fleisher at Avid Radiopharmaceuticals/Eli Lilly, ...

Paul Taylor Wins 2020 Potamkin Prize

COMMUNITY NEWS 2020-05-01 Community News In a virtual ceremony hosted by the American Brain Foundation on April 29, Potamkin Philanthropies awarded the 2020 Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases to J. Paul Taylor from St. Jude Children’s Research ...

Without SORL1, Endosomes Swell in Neurons but not Microglia

RESEARCH NEWS 2020-06-02 Research News Scientists have linked loss-of-function mutations in SORL1 to overproduction of Aβ and to early onset Alzheimer’s disease. Now, in the June 2 Cell Reports, researchers led by Jessica Young at the University of Washington, Seattle, report ...

Paper Alert: CryoEM Structures of α-Synuclein Published

RESEARCH NEWS 2020-05-27 Research News In the May 27 Nature, scientists publish the first-ever cryo-electron microscopy of α-synuclein fibrils. With resolution down to the atomic level, the analysis revealed two types of asymmetric fibril, each comprising two different ...

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