AbbVie’s Tau Antibody Flops in Progressive Supranuclear Palsy

RESEARCH NEWS 2019-07-26 Research News According to an industry report today, AbbVie has called a halt to the Phase 2 trial of its anti-tau antibody ABBV-8E12 for progressive supranuclear palsy after it failed a futility analysis. AbbVie announced the termination during a ...

Imaging Model Locates Epicenter of Disease, Predicts Atrophy

RESEARCH NEWS 2019-10-18 Research News In neurodegenerative diseases, specific brain regions take the brunt of pathology and atrophy. However, differences from one patient to another make it hard to predict the precise path of progression for any one person. Now, scientists led ...

Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance

RESEARCH NEWS 2019-11-08 Research News Researchers are searching for ways to dampen harmful inflammation and boost microglial phagocytosis in the Alzheimer’s brain. In the November 4 Proceedings of the National Academy of Sciences, researchers led by Hee Kyung Jin and Jae-sung ...

Microglia Inflammasome Stokes Tau Phosphorylation, Tangles

RESEARCH NEWS 2019-11-22 Research News Microglia have been firmly linked to amyloid plaques, but scientists are only beginning to examine their relationship to tau tangles. In the November 20 Nature, Michael Heneka and colleagues at the German Center for Neurodegenerative ...

Human and Mouse Microglia React Differently to Amyloid

RESEARCH NEWS 2020-01-17 Research News Transgenic mice fail to capture many aspects of Alzheimer’s disease, and a new transcriptional study lays bare one reason. Brain cells in the two species, it turns out, respond quite differently to amyloidosis. In the January 13 Nature ...

Exposure, Exposure, Exposure? At CTAD, Aducanumab Scientists Make a Case

CONFERENCE COVERAGE 2019-12-13 Conference Coverage There was a new feeling in the air at the 12th Clinical Trials on Alzheimer’s Disease conference. It felt good: After decades of failure, the field might finally be turning a corner. The renewed optimism at the meeting, held December 4 ...

Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition

RESEARCH NEWS 2020-05-09 Research News ApoE4 weakens the blood-brain barrier in the hippocampus, and in this way takes its toll on cognition, according to a study published April 29 in Nature. Researchers led by Berislav Zlokovic of the University of Southern California in Los ...

Social Distancing Shutters Alzheimer’s Research

COMMUNITY NEWS 2020-03-27 Community News “Do what you can, with what you have, where you are.” Theodore Roosevelt. Globally the story is the same almost everywhere. Scientists are in lockdown, most staying at home as skeleton crews tend to the most crucial experiments and valuable ...

Human Blood-Brain Barrier Model Blames Pericytes for CAA

RESEARCH NEWS 2020-06-15 Research News The full complexity of the blood-brain barrier, with its different cell types acting together, has been difficult to model in vitro. In the June 8 Nature Medicine, researchers led by Li-Huei Tsai at the Massachusetts Institute of Technology, ...

Too Phatal: How Microglia, Astrocytes Snuff Out Dying Neurons

RESEARCH NEWS 2020-06-26 Research News Conventional wisdom holds that microglia are the main phagocytes of the brain, mopping up dead cells and debris. The reality is more complicated, according to scientists led by Jaime Grutzendler at Yale School of Medicine in New Haven, ...

Widely Used Tau Seeding Assay Challenged

RESEARCH NEWS 2020-05-22 Research News Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for ...

Herpes Viruses and Alzheimer’s—The Debate Continues

RESEARCH NEWS 2020-01-23 Research News In 2018, researchers created a stir with a multi-network analysis of postmortem tissue that suggested viruses—particularly human herpes—might disrupt molecular pathways in the brains of Alzheimer’s disease patients. Now, researchers led by ...

New PET Staging Scheme for Amyloid?

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Scientists are becoming more nuanced in how they use amyloid scans—not just to detect the presence of Alzheimer’s pathology, but also to pinpoint disease stage. At this year’s Alzheimer’s Association International Conference, held July ...

Cognitive Decline Trips Up API Trials of BACE Inhibitor

RESEARCH NEWS 2019-07-12 Research News The Alzheimer’s field was dealt another body blow yesterday with the announcement of a premature end to testing of Novartis/Amgen’s BACE inhibitor CNP520, aka umibecestat, in two Phase 2/3 trials. Part of the Alzheimer’s Prevention ...

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