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Acetaminophen Derivative Tempers Microglia, Spurs Plaque Clearance

RESEARCH NEWS 2019-11-08 Research News Researchers are searching for ways to dampen harmful inflammation and boost microglial phagocytosis in the Alzheimer’s brain. In the November 4 Proceedings of the National Academy of Sciences, researchers led by Hee Kyung Jin and Jae-sung ...

Microglia Inflammasome Stokes Tau Phosphorylation, Tangles

RESEARCH NEWS 2019-11-22 Research News Microglia have been firmly linked to amyloid plaques, but scientists are only beginning to examine their relationship to tau tangles. In the November 20 Nature, Michael Heneka and colleagues at the German Center for Neurodegenerative ...

Human and Mouse Microglia React Differently to Amyloid

RESEARCH NEWS 2020-01-17 Research News Transgenic mice fail to capture many aspects of Alzheimer’s disease, and a new transcriptional study lays bare one reason. Brain cells in the two species, it turns out, respond quite differently to amyloidosis. In the January 13 Nature ...

Exposure, Exposure, Exposure? At CTAD, Aducanumab Scientists Make a Case

CONFERENCE COVERAGE 2019-12-13 Conference Coverage There was a new feeling in the air at the 12th Clinical Trials on Alzheimer’s Disease conference. It felt good: After decades of failure, the field might finally be turning a corner. The renewed optimism at the meeting, held December 4 ...

Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition

RESEARCH NEWS 2020-05-09 Research News ApoE4 weakens the blood-brain barrier in the hippocampus, and in this way takes its toll on cognition, according to a study published April 29 in Nature. Researchers led by Berislav Zlokovic of the University of Southern California in Los ...

Social Distancing Shutters Alzheimer’s Research

COMMUNITY NEWS 2020-03-27 Community News “Do what you can, with what you have, where you are.” Theodore Roosevelt. Globally the story is the same almost everywhere. Scientists are in lockdown, most staying at home as skeleton crews tend to the most crucial experiments and valuable ...

Widely Used Tau Seeding Assay Challenged

RESEARCH NEWS 2020-05-22 Research News Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for ...

Herpes Viruses and Alzheimer’s—The Debate Continues

RESEARCH NEWS 2020-01-23 Research News In 2018, researchers created a stir with a multi-network analysis of postmortem tissue that suggested viruses—particularly human herpes—might disrupt molecular pathways in the brains of Alzheimer’s disease patients. Now, researchers led by ...

Aβ Acts Through Pericytes to Throttle Brain Blood Flow

RESEARCH NEWS 2019-06-22 Research News In Alzheimer’s disease, blood flows sluggishly through the brain, partly because Aβ provokes small blood vessels to constrict. In the June 20 Science, researchers led by David Attwell at University College London blame this on pericytes, ...

New PET Staging Scheme for Amyloid?

CONFERENCE COVERAGE 2019-07-25 Conference Coverage Scientists are becoming more nuanced in how they use amyloid scans—not just to detect the presence of Alzheimer’s pathology, but also to pinpoint disease stage. At this year’s Alzheimer’s Association International Conference, held July ...

Cognitive Decline Trips Up API Trials of BACE Inhibitor

RESEARCH NEWS 2019-07-12 Research News The Alzheimer’s field was dealt another body blow yesterday with the announcement of a premature end to testing of Novartis/Amgen’s BACE inhibitor CNP520, aka umibecestat, in two Phase 2/3 trials. Part of the Alzheimer’s Prevention ...

In Alzheimer’s, More TREM2 Is Good for You

RESEARCH NEWS 2019-08-29 Research News Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease? A new study suggests as much. In the August 28 Science Translational Medicine ...

Blood Pressure: How Low to Prevent Dementia—and When?

RESEARCH NEWS 2019-08-23 Research News Mounting evidence suggests midlife hypertension negatively affects late-life cognition and that treating it could help. Three new papers support this idea. In the August 20 Lancet, researchers led by Marcus Richards, Nick Fox, and Jonathan ...

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