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RESEARCH NEWS 2015-10-16 Research News Could infectious agents that enter the brain contribute in some way to neurodegenerative disease? This idea has been fermenting in recent years, and new data from researchers led by Luis Carrasco at the Autonomous University of Madrid add ...
RESEARCH NEWS 2016-09-22 Research News A paper in the September 21 Journal of Neuroscience suggests that two prominent phenotypes considered relevant to Alzheimer’s disease are artifacts caused by overexpression of the amyloid precursor protein (APP). Scientists led by Takaomi ...
COMMUNITY NEWS 2017-05-30 Community News On May 20, at age 93, Robert Davis Terry passed away in Carlsbad, California. Terry had been in declining health for some time, according to Michael Shelanski of Columbia University, New York, an early trainee and longtime friend. During ...
RESEARCH NEWS 2018-02-02 Research News For decades, scientists have yearned for a blood test that can tell who accumulates amyloid in the brain. A simple blood draw would help fill clinical trials much more quickly and cheaply than PET scans or lumbar punctures. The dream looks ...
RESEARCH NEWS 2018-06-29 Research News Aβ is generally considered a rogue peptide, but recent research is building a case that it may have a secret identity as an antimicrobial superhero. Confronted with an unwelcome bacteria or fungus, the peptide quickly forms amyloid fibrils ...
COMMUNITY NEWS 2013-03-29 Community News In light of recent failures in high-profile Alzheimer’s disease clinical trials, scientists have turned their attention with increasing urgency toward testing therapies in early-stage patients who have underlying brain pathology but little ...
RESEARCH NEWS 2015-07-24 Research News Tau protein undergoes a bewildering variety of modifications, from phosphorylations and acetylations to the addition of sugar groups. What roles do these modifications play, and which most likely associate with disease? To tackle this ...
RESEARCH NEWS 2017-11-11 Research News Could Aβ from the blood contribute to Alzheimer’s disease? In the October 31 Molecular Psychiatry, researchers led by Yan-Jiang Wang at Daping Hospital, Third Military Medical University in Chongqing, China, and Weihong Song at the ...
RESEARCH NEWS 2018-06-12 Research News Eli Lilly and AstraZeneca today announced that they will end two ongoing Phase 3 trials of lanabecestat, a small-molecule BACE inhibitor the two companies have been developing jointly since 2014. According to the program’s independent data ...
RESEARCH NEWS 2019-05-29 Research News When a virus enters a biological fluid of a host—blood, lung, or cerebrospinal fluid—it becomes ensheathed by a unique set of proteins from its new environment. The proteins that make up the sheath differ depending on the fluid and on the ...
CONFERENCE COVERAGE 2004-11-03 Conference Coverage A mouse model that mimics both signature pathologies of Alzheimer disease develops a day-to-day forgetfulness at four months, a young adult age when the animals' brains accumulate the Aβ peptide inside their neurons but don’t yet ...
RESEARCH NEWS 2004-02-17 Research News Add a new strand to the growing web of relationships among production of the Aβ peptide, regulation of cholesterol and other lipids, oxidative stress, and the death of neurons in Alzheimer's. Mark Mattson and colleagues at the National ...
RESEARCH NEWS 2010-08-18 Research News Eli Lilly and Company announced yesterday that it has halted its Semagacestat γ-secretase inhibitor program. Preliminary results from two ongoing Phase 3 trials (the IDENTITY and IDENTITY-2 trials) revealed that the drug not only failed to ...
COMMUNITY NEWS 2010-06-16 Community News The fight against Alzheimer disease rallies warriors of many sorts—families caring for afflicted loved ones, scientists toiling late nights in the lab to unravel disease mechanisms, advocates lobbying for research funding, companies ...
CONFERENCE COVERAGE 2012-05-16 Conference Coverage Updated 21 May 2012 On May 21, the New York Times editorial page commented on this upcoming trial. On 15 May at the Alzheimer’s Disease Research Summit 2012, a conference hosted by the National Institute on Aging, Francis Collins ...
