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Dale Schenk, 59, Pioneer of Alzheimer’s Immunotherapy

COMMUNITY NEWS 2016-10-03 Community News Dale Schenk, a leader in the field of Alzheimer’s disease immunotherapy passed away Friday, September 30, after a battle with pancreatic cancer that started in 2014. Schenk had been working until recently. He was 59. Dale Schenk at the ...

Field Loses Beloved Wizard of Glia, Ben Barres, 63

COMMUNITY NEWS 2018-01-04 Community News Alzheimer’s researchers, and colleagues across neuroscience, are mourning the loss of Ben Barres, who died December 27 of pancreatic cancer at the age of 63. First diagnosed in March 2016, Barres continued pursuing the work he loved and ...

Mark Smith, 45, Is Struck and Killed by Hit-and-Run Driver

COMMUNITY NEWS 2010-12-21 Community News Updated 22 December 2010. View In Memory: Mark A. Smith on the Journal of Alzheimer's Disease website. Mark A. Smith 21 December 2010. As shocked researchers notify each other privately, the Alzforum editors are saddened to inform the ...

Biogen/Eisai Halt Phase 3 Aducanumab Trials

RESEARCH NEWS 2019-03-21 Research News Today, Biogen and Eisai announced they would terminate the Phase 3 ENGAGE and EMERGE trials of aducanumab for early Alzheimer’s disease. A futility analysis run by an independent data-monitoring committee concluded that that trials would not ...

Coronavirus Takes Its Toll on Alzheimer’s Clinical Studies

COMMUNITY NEWS 2020-03-27 Community News The coronavirus pandemic is upending not only life as we knew it, but Alzheimer’s clinical studies as well. In the United States, Europe, and Australia, most sites have put observational cohort studies on hold, and many have stopped dosing ...

‘Reports of My Death Are Greatly Exaggerated.’ Signed, Aducanumab

RESEARCH NEWS 2019-10-24 Research News On October 22, Biogen stunned the Alzheimer’s field by announcing that aducanumab —presumed dead last March after failing a futility analysis—appears to have worked in one of its two Phase 3 trials, after all. Based on the results of a new ...

Familial AD Mutations, β-CTF, Spell Trouble for Endosomes

RESEARCH NEWS 2019-08-19 Research News Faltering endosomal trafficking appears to be the common modus operandi by a range of familial Alzheimer’s mutations. In the August 14 Neuron, researchers led by Marc Tessier-Lavigne of Stanford University reported initial findings from a ...

Bapineuzumab Phase 3: Target Engagement, But No Benefit

CONFERENCE COVERAGE 2012-09-12 Conference Coverage Bapineuzumab prevents accumulation of Aβ in the brain of patients with mild to moderate Alzheimer’s disease and lowers phospho-tau (p-tau) in their cerebrospinal fluid (CSF), according to analysis presented September 11 at the European ...

Field Loses Another Pioneer with Passing of Allen Roses, 73

COMMUNITY NEWS 2016-10-04 Community News Even as the Alzheimer’s research community was reeling from the news of Dale Schenk’s untimely death, the next blow hit. Also on September 30, Allen Roses had passed away. Two titans struck down on the same day? Some might rightly suspect a ...

New Definition of Alzheimer’s Hinges on Biology, Not Symptoms

RESEARCH NEWS 2018-04-13 Research News After years of edging closer to a biological, biomarker-based diagnosis of Alzheimer’s, researchers formally took the leap this week. A committee assembled by the National Institute on Aging and the Alzheimer’s Association published a new ...

Anne Cataldo, 57, Autophagy Researcher Known for Generous Collegiality

COMMUNITY NEWS 2009-04-20 Community News Anne Cataldo 20 April 2009. It is with deep sadness that we inform the Alzheimer research community of the passing of Anne Cataldo, who directed the Laboratories for Molecular Neuropathology at McLean Hospital, Belmont, Massachusetts. ...

BAN2401 Removes Brain Amyloid, Possibly Slows Cognitive Decline

CONFERENCE COVERAGE 2018-07-26 Conference Coverage The last full day of the Alzheimer's Association International Conference, which ended today in Chicago, saw scientists pack a room the size of an aircraft hangar in anticipation of a late addition to the scientific program. They ...

Colleagues Mourn Loss of Rahul Desikan, Age 41, to ALS

COMMUNITY NEWS 2019-08-08 Community News Neuroscientists are mourning the loss of a beloved colleague and innovator. At the age of 41, Rahul Desikan died of amyotrophic lateral sclerosis (ALS)—a devastating neurodegenerative disease that he studied. Despite being struck with an ...

Statins Boost α-Secretase, but Not Through Cholesterol

RESEARCH NEWS 2005-01-13 Research News In efforts to interfere with Aβ peptide production, most of the attention has been lavished on the β- and γ-secretase enzymes. Could, however, their neglected cousin α-secretase prove to be the better target? In an article published January ...

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