51 RESULTS
RESEARCH NEWS 2020-05-08 Research News Looking for a way to model the human brain in a dish? Consider using a gel-filled silk sponge as a three-dimensional scaffold to mimic the vaunted organ’s architecture. That, at least, is the approach published by David Kaplan at Tufts Unive
RESEARCH NEWS 2020-05-13 Research News Behold the mouse brain, in glorious new detail. In the May 14 Cell, researchers led by Julie Harris and Lydia Ng at the Allen Institute for Brain Science in Seattle debut the third iteration of the Allen Mouse Brain atlas. Called the Common
RESEARCH NEWS 2020-05-23 Research News RNA sequencing studies of postmortem human brain samples have generated massive datasets implicating all manner of biological functions in Alzheimer’s disease. But how do these findings translate to proteins—where the biological rubber meets
RESEARCH NEWS 2020-05-26 Research News In carriers of a pathogenic mutation in presenilin 1, plasma levels of the neurodegeneration marker neurofilament light (NfL) start to diverge from those in noncarriers more than two decades prior to when Alzheimer’s symptoms begin. That was
RESEARCH NEWS 2020-05-30 Research News Tangles creep through a person’s brain as Alzheimer’s disease progresses; alas, researchers disagree about what drives the spread of this pathology. In the May 26 Nature Communications, a collaborative group led by Alan Evans at McGill Unive
RESEARCH NEWS 2020-03-11 Research News TMEM106b, a gene carrying risk variants for frontotemporal dementia (FTD), coordinates the steady stream of lysosomal traffic along axons, according to a study published March 10 in Cell Reports. Researchers led by Markus Damme of Christian
RESEARCH NEWS 2020-03-13 Research News The phosphorylation of tau in the Alzheimer’s brain is not a binary state. It evolves over time, passing through distinct stages that reflect worsening disease, according to a study in the March 11 Nature Medicine led by Randall Bateman and
CONFERENCE COVERAGE 2020-04-10 Conference Coverage A flood of recent data seems to leave little doubt that phospho-tau217 is the better of the soluble tau markers for studying Alzheimer’s disease thus far. At this year’s virtual AAT-AD/PD meeting, Oskar Hansson, Lund University, Sweden
COMMUNITY NEWS 2020-04-21 Community News Many people with Lewy body diseases (LBDs) such as Parkinson’s ultimately develop dementia, and many have Aβ plaques and tau tangles. Do they have two diseases at the same time, or is this combination of scourges a unique entity unto itself
COMMUNITY NEWS 2020-05-01 Community News In a virtual ceremony hosted by the American Brain Foundation on April 29, Potamkin Philanthropies awarded the 2020 Potamkin Prize for Research in Pick’s, Alzheimer’s, and Related Diseases to J. Paul Taylor from St. Jude Children’s Research
RESEARCH NEWS 2020-05-02 Research News Results from a large autopsy validation study suggest that flortaucipir PET can help clinicians diagnose late-stage Alzheimer’s disease. In the April 27 JAMA Neurology, researchers led by Adam Fleisher at Avid Radiopharmaceuticals/Eli Lilly,
RESEARCH NEWS 2020-05-27 Research News In the May 27 Nature, scientists publish the first-ever cryo-electron microscopy of α-synuclein fibrils. With resolution down to the atomic level, the analysis revealed two types of asymmetric fibril, each comprising two different protofibri
RESEARCH NEWS 2020-05-28 Research News Induced pluripotent stem cell models of Alzheimer’s disease have become important because they allow researchers to study human neurons carrying AD mutations. However, iPSC lines take weeks to establish, require viral vectors to reprogram ad
RESEARCH NEWS 2020-06-02 Research News Scientists have linked loss-of-function mutations in SORL1 to overproduction of Aβ and to early onset Alzheimer’s disease. Now, in the June 2 Cell Reports, researchers led by Jessica Young at the University of Washington, Seattle, report tha
CONFERENCE COVERAGE 2020-04-16 Conference Coverage Three the approved drugs for Alzheimer’s disease attempt to boost the brain’s supply of acetylcholine, a critical neurotransmitter for cognition that wanes in people with the disease. But might crumbling of the brain’s cholinergic syst
