Coronavirus Takes Its Toll on Alzheimer’s Clinical Studies

COMMUNITY NEWS 2020-03-27 Community News The coronavirus pandemic is upending not only life as we knew it, but Alzheimer’s clinical studies as well. In the United States, Europe, and Australia, most sites have put observational cohort studies on hold, and many have stopped dosing ...

Plaques, Tangles Throw Off the Brain’s Rhythms

RESEARCH NEWS 2020-03-13 Research News Brain rhythms change their tune in people with Alzheimer’s disease, and they do so to the beat of Aβ and tau, according to a study published in Science Translational Medicine on March 11. Researchers led by Keith Vossel and Srikantan ...

Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition

RESEARCH NEWS 2020-05-09 Research News ApoE4 weakens the blood-brain barrier in the hippocampus, and in this way takes its toll on cognition, according to a study published April 29 in Nature. Researchers led by Berislav Zlokovic of the University of Southern California in Los ...

Social Distancing Shutters Alzheimer’s Research

COMMUNITY NEWS 2020-03-27 Community News “Do what you can, with what you have, where you are.” Theodore Roosevelt. Globally the story is the same almost everywhere. Scientists are in lockdown, most staying at home as skeleton crews tend to the most crucial experiments and valuable ...

Widely Used Tau Seeding Assay Challenged

RESEARCH NEWS 2020-05-22 Research News Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. In a preprint on bioRxiv, researchers led by Eckhard Mandelkow at the German Center for ...

Mutations in Epigenetic Gene Linked to Neurodegeneration

RESEARCH NEWS 2020-05-01 Research News Rare but powerful gene variants help scientists understand how disease develops, but they are hard to find. By pooling data on people with different early onset dementias to get cohorts of a workable size, researchers pulled out an ...

Alzheimer’s Gene BIN1 Promotes Synaptic Transmission

RESEARCH NEWS 2020-03-18 Research News BIN1, one of the strongest genetic risk factors for late-onset Alzheimer’s disease, encodes a protein that dabbles in many cellular functions, taking a hand in Aβ production, tau propagation, and microglial function. Now, in the March 10 ...

Stress-Associated Protein Modulates γ-Secretase to Make More Aβ

RESEARCH NEWS 2020-03-21 Research News In the March 17 Science Signaling, researchers led by Yong-Keun Jung at Seoul National University, South Korea, reported a new modulator of γ-secretase that appears to preferentially affect cleavage of amyloid precursor protein. Stress ...

Sigh of Relief? Lung Effects of LRRK2 Inhibitors are Mild.

RESEARCH NEWS 2020-04-24 Research News Proponents of LRRK2 inhibitor programs may breathe easier following a paper in the April 22 Science Translational Medicine. A collaboration led by researchers at the Michael J. Fox Foundation found that three different inhibitors of this ...

Could Tau PET Replace Amyloid Biomarkers as a Diagnostic for AD?

RESEARCH NEWS 2020-05-15 Research News The particular type of tangle found in Alzheimer’s is unique to this disease, making tau PET a highly specific marker. In the May 11 JAMA Neurology, researchers led by Oskar Hansson at Skåne University Hospital in Malmö, Sweden, reinforce ...

Gut Microbes: The Difference Between Life and Death in C9ORF72 Mice

RESEARCH NEWS 2020-05-15 Research News When Kevin Eggan of Harvard University decided to raise some C9ORF72-deficient mice down the road at MIT’s Broad Institute, he had little inkling of the can of worms—or microbes—that he was about to open. At Harvard, the C9-deficient mice ...

Molecular Transport Vehicle Shuttles Therapies into Brain

RESEARCH NEWS 2020-05-29 Research News Researchers have devised a new way to sneak therapeutic cargo across the blood-brain barrier. Into the constant region of a human IgG1 antibody, they slid a domain that latches onto receptors that carry transferrin into the brain. On the ...

Traveling C9ORF72 Dipepides Jam Proteasomes in Neighboring Neurons

RESEARCH NEWS 2020-03-20 Research News Hexanucleotide expansions in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia, but how the dipeptide repeats (DPRs) translated from the expansions incite disease still puzzles ...

Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third

RESEARCH NEWS 2020-04-17 Research News A meta-analysis of 22 cohorts seems to leave little doubt that variants of the longevity gene klotho protect against dementia—at least in people unfortunate enough to have inherited an ApoE4 allele. Researchers led by Michael Belloy, ...

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