225 RESULTS
RESEARCH NEWS 2020-03-21 Research News In the March 17 Science Signaling, researchers led by Yong-Keun Jung at Seoul National University, South Korea, reported a new modulator of γ-secretase that appears to preferentially affect cleavage of amyloid precursor protein. Stress-assoc
RESEARCH NEWS 2020-04-24 Research News Proponents of LRRK2 inhibitor programs may breathe easier following a paper in the April 22 Science Translational Medicine. A collaboration led by researchers at the Michael J. Fox Foundation found that three different inhibitors of this Par
RESEARCH NEWS 2020-05-15 Research News The particular type of tangle found in Alzheimer’s is unique to this disease, making tau PET a highly specific marker. In the May 11 JAMA Neurology, researchers led by Oskar Hansson at Skåne University Hospital in Malmö, Sweden, reinforce th
RESEARCH NEWS 2020-05-15 Research News When Kevin Eggan of Harvard University decided to raise some C9ORF72-deficient mice down the road at MIT’s Broad Institute, he had little inkling of the can of worms—or microbes—that he was about to open. At Harvard, the C9-deficient mice sp
RESEARCH NEWS 2020-05-29 Research News Researchers have devised a new way to sneak therapeutic cargo across the blood-brain barrier. Into the constant region of a human IgG1 antibody, they slid a domain that latches onto receptors that carry transferrin into the brain. On the oth
COMMUNITY NEWS 2020-06-23 Community News Part 2 of 2 As Alzheimer’s research comes to, scientists are taking stock of the damage. In the academic world, the main cost was time (see Part 1 of this story). For most clinical studies, the damage was more tangible, with at least a bri
RESEARCH NEWS 2019-09-04 Research News Are microglia the masterminds of amyloid plaque formation? In the August 21 Nature Communications, researchers led by Kim Green at the University of California, Irvine, suggest these cells seed amyloid deposits. In a mouse model of amyloidos
RESEARCH NEWS 2019-09-27 Research News Regular exercise infuses the blood with factors that benefit the brain, according to a manuscript posted on the bioRχiv preprint server on September 19. Researchers led by Tony Wyss-Coray of Stanford University reported that plasma taken fro
RESEARCH NEWS 2019-07-16 Research News Two recent papers detail stumbles and strides for tau models. In the June 6 Nature Communications, scientists led by Michael Koob and Karen Ashe, University of Minnesota, Minneapolis, reported that most of the rampant neurodegeneration seen
RESEARCH NEWS 2019-08-01 Research News As microglia become more central to Alzheimer’s research, researchers are seeking better model systems to study their in vivo behavior. In culture, the cells rapidly alter their gene expression, and mouse microglia respond differently to dis
RESEARCH NEWS 2019-09-24 Research News Mitochondrial fragments, jettisoned by stressed cells, create trouble for other cells, according to a study in the September 23 Nature Neuroscience. Researchers led by Daria Mochly-Rosen at Stanford University School of Medicine report that
RESEARCH NEWS 2019-10-05 Research News Critics of the amyloid hypothesis point out that some people with brain amyloid are cognitively fine, thank you very much. Indeed, variability in plaque burden among cognitively normal older people, combined with typically short follow-up pe
RESEARCH NEWS 2019-10-08 Research News As if the known universe of RNAs wasn’t vast enough, here’s a new entity: circular RNA. These rings form when the ends of a linear transcript become fastened together. Are they a result of splicing gone haywire, or do they serve a purpose? T
RESEARCH NEWS 2019-10-11 Research News Scientists in Portugal led by Julie Ribot and Bruno Silva-Santos, Universidade de Lisboa, report that a gaggle of specialized T cells hide out in the meninges of the healthy mouse brain, where they support both synaptic plasticity and short-
RESEARCH NEWS 2019-10-23 Research News A multi-institutional group, including members of the Tau Consortium, unveiled a stem cell tool kit for scientists studying primary tauopathies. In the November 12 issue of Stem Cell Reports, researchers co-led by Celeste Karch of Washington
