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CONFERENCE COVERAGE 2020-04-22 Conference Coverage Certain variants in the TREM2 gene more than triple a person’s risk of AD, seemingly by sapping the protective function this microglial receptor performs. According to findings presented at the virtual AAT-AD/PD meeting, held April 2 t
CONFERENCE COVERAGE 2020-04-22 Conference Coverage Roche and Prothena today announced topline results from the first half of their Phase 2 trial of the α-synuclein antibody prasinezumab. Results were negative on the MDS-UPDRS, the primary outcome measure, but the company said it saw s
RESEARCH NEWS 2020-05-02 Research News Genome-wide association studies have uncovered a thicket of risk variants for neurologic diseases, but in which cells are these disease genes doing their dirty work? Merging GWAS with gene-expression signatures across the mouse nervous syste
RESEARCH NEWS 2020-05-22 Research News Part 1 of 2 As coronavirus lockdowns have led to noticeably clearer skies above many metropolitan areas, people are beginning to wonder anew about the effects of air pollution. Traffic and industrial exhaust have long been linked to respirat
RESEARCH NEWS 2020-05-23 Research News Part 2 of 2 For decades, studies of pulmonary and vascular systems dominated the air-pollution-research landscape. Researchers paid scant attention to the brain, which they considered safely ensconced behind the blood-brain barrier. But the
RESEARCH NEWS 2020-06-01 Research News Synapses are central in Alzheimer’s disease, but they are hard to study. The microscopic techniques that offer a glimpse at these tiny structures require expensive equipment and laborious ultra-sectioning of brain tissue, and cover only very
RESEARCH NEWS 2020-06-12 Research News Living in an underserved neighborhood has been linked to all manner of health problems and disadvantages, and a new study adds Alzheimer’s disease to the list. In a paper published June 11 in JAMA Network Open, researchers led by Amy Kind at
RESEARCH NEWS 2020-06-19 Research News Amyloid-β is not the only component of the senile plaques that mark Alzheimer’s disease. Are the others mere bystanders that get caught in a web of Aβ fibrils, or are they more nefarious, instigating growth of these deposits? For the protein
RESEARCH NEWS 2020-06-30 Research News Massive genome-wide association studies for Alzheimer’s disease have primarily correlated genetic variants with clinical diagnosis, a rubric that is fraught with uncertainty. In a GWAS published June 22 in JAMA Neurology, researchers led by
CONFERENCE COVERAGE 2020-04-15 Conference Coverage As the Alzheimer’s field branches out its therapeutics search beyond Aβ and tau, some of those approaches are showing glimmers of promise. The second biannual Advances in Alzheimer’s and Parkinson’s Therapies Focus Meeting (AAT-AD/PD),
CONFERENCE COVERAGE 2019-08-15 Conference Coverage At one end of the Alzheimer’s disease genetic spectrum lie the catastrophic mutations in APP and presenilin that lead to autosomal-dominant, early onset AD. At the other end are dozens of common variants that each contribute a smidgen
CONFERENCE COVERAGE 2019-08-02 Conference Coverage At the fifth annual DIAD family meeting held July 13 in Los Angeles, Randall Bateman of Washington University, St. Louis, stood before an audience of laypeople who had come from around the world to hear the latest about the grand proje
RESEARCH NEWS 2019-08-15 Research News Variants in the MS4A gene cluster influence AD risk, at least in part, by tweaking levels of another AD risk factor, TREM2. In a study published in Science Translational Medicine on August 14, researchers co-led by Bruno Benitez, Celeste Kar
CONFERENCE COVERAGE 2019-09-07 Conference Coverage Researchers have linked dozens of genetic loci to late-onset Alzheimer’s disease and found dozens more that cause familial forms of AD and other neurodegenerative diseases. Teasing out how each contributes to pathology has proven a lit
CONFERENCE COVERAGE 2019-08-22 Conference Coverage In the last three decades, scientists have made strides in using biomarkers to diagnose Alzheimer’s disease and track its progression. Along with cerebrospinal fluid Aβ, tau, and phospho-tau, a handful of new markers, such as neurofila
