75 RESULTS
CONFERENCE COVERAGE 2019-04-23 Conference Coverage Much of the research on microglia in Alzheimer’s disease has focused on the TREM2 receptor (see Part 4 of this series). But other microglial receptors play a hand in age- and injury-related activation as well (e.g., Apr 2019 news on C
CONFERENCE COVERAGE 2019-04-30 Conference Coverage The quest for a noninvasive diagnostic test is leading Parkinson’s scientists to unlikely places. One is inside the mouth. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases in Lisbon, Portugal, Giorgio Vivacq
RESEARCH NEWS 2019-05-09 Research News The growth of tau tangle pathology in the brain’s cortex only happens in people who also have Aβ plaques, and it correlates with cognitive decline. These conclusions are supported by the largest, multicenter, longitudinal tau PET study condu
CONFERENCE COVERAGE 2019-05-10 Conference Coverage Nearly half of people with Alzheimer’s can’t sleep at night, waking up more often and staying awake longer than others their age. This causes nighttime wandering, and worsens cognition and depression. Despite the burden for both patien
RESEARCH NEWS 2019-05-17 Research News If using flashing lights to treat Alzheimer’s disease sounds like science fiction, then brace yourself, because new data strengthen the case for this idea. Previously, Li-Huei Tsai and colleagues at MIT had reported that a treatment consisti
CONFERENCE COVERAGE 2019-05-17 Conference Coverage At the AD/PD 2019 conference held recently in Lisbon, the amyloid hypothesis was reeling from repeated gut punches in the clinic. Both antibodies and BACE inhibitors are facing relentless criticism from academic scientists and biopharm
RESEARCH NEWS 2019-05-23 Research News Myriad studies have placed microglia right in the middle of AD pathogenesis, but defining what, when, and how these cells influence the disease process in a person’s brain is difficult. Three recent gene-expression studies—one in Nature and
RESEARCH NEWS 2019-05-23 Research News It’s not just the dark web. The dark genome, too, hides some nefarious goings-on, and it will take creative sleuthing to drag them into the light. Genomic sequencing has had some success scanning for rare variants that cause disease. Still,
RESEARCH NEWS 2019-05-30 Research News Known gene mutations explain but a fraction of early onset Alzheimer’s disease. A majority of people who become symptomatic before age 65 have neither an autosomal-dominant inheritance pattern nor mutation. So what is causing their dementia?
RESEARCH NEWS 2019-06-06 Research News Brain organoids, those tiny balls of cells grown in a dish to model the human brain, are plagued by a major problem—they are each unique. That may be about to change. Scientists led by Paola Arlotta, Harvard University, Cambridge, Massachuse
RESEARCH NEWS 2019-06-11 Research News Human neurons sprouted more synapses and fired off more action potentials when bathed in serum from young, but not old, mice, according to a study published June 3 in Proceedings of the National Academy of Sciences. Kathlyn Gan and Thomas Sü
RESEARCH NEWS 2019-06-07 Research News Can researchers speed the degradation of aggregated, toxic proteins without harming physiological forms? In the June 5 Science Translational Medicine, researchers led by Juan Gerez and Paola Picotti at the Swiss Federal Institute of Technolo
RESEARCH NEWS 2019-06-12 Research News In brain disease, microglia can be villains or heroes. How to encourage the latter? In the June 10 Nature Neuroscience, researchers led by Veronique Miron at the University of Edinburgh tried by killing off the troublemakers. In a mouse mode
CONFERENCE COVERAGE 2019-05-10 Conference Coverage As neuroinflammation becomes ever more deeply implicated in Alzheimer’s disease, therapies targeting this process are starting to enter clinical trials. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held
CONFERENCE COVERAGE 2019-03-21 Conference Coverage Outside the daffodils and forsythia were blooming, but the group assembled in Nashville, Tennessee, hardly took notice. At the GAP-Net Site Optimization Conference, held February 27–March 1, representatives of 61 academic and private c
