75 RESULTS
RESEARCH NEWS 2019-05-31 Research News The lucky carriers of a coding variant in the phospholipase Cγ2 (PLCG2) gene may reap even more benefits than previously thought. In the May 27 Acta Neuropathologica, researchers confirm that people with the rs72824905-G allele not only enjo
RESEARCH NEWS 2019-06-08 Research News Amyloid deposits without causing symptoms for years, but once tau tangles accumulate, cognition craters. That’s the prevailing model for the progression of Alzheimer’s disease. The newest support for it comes from the first longitudinal stud
RESEARCH NEWS 2019-06-14 Research News For decades, researchers have wondered why Aβ deposits in the brain correlate poorly with local neural activity and cognition. Perhaps the correlation was not that weak, after all. A study in the June 4 Nature Communications suggests that it
RESEARCH NEWS 2019-03-20 Research News The longevity gene klotho keeps memory keen, but how? New research raises the possibility that it might influence cognition through its signaling partners FGF23 and the fibroblast growth factor (FGF) receptor. In the March 7 eNeuro, Gwendaly
RESEARCH NEWS 2019-03-21 Research News Whether sustained on the field or in the ring, repeated blows to the head result in a distinctive strain of tau filaments in the brain. In the March 20 Nature, researchers led by Sjors Scheres and Michel Goedert of the MRC Laboratory of Mole
RESEARCH NEWS 2019-03-25 Research News Does Alzheimer’s disease retard the birth of new neurons in the hippocampus? Data from mouse models suggests it might, but evidence from human brain has been lacking. In today’s Nature Medicine, researchers led by María Llorens-Martín at the
RESEARCH NEWS 2019-04-05 Research News Microglia tend to get off-kilter in Alzheimer’s and other neurodegenerative diseases. Now, researchers in Tony Wyss-Coray’s lab at Stanford University believe they have discovered a means of restoring their homeostasis. On April 3 in Nature
CONFERENCE COVERAGE 2019-05-01 Conference Coverage Despite years of study, ApoE still has secrets to give up. At the 14th International Conference on Alzheimer’s and Parkinson’s Diseases, held March 27–31 in Lisbon, Portugal, researchers indicted ApoE4 on several fronts. They charged i
RESEARCH NEWS 2019-05-09 Research News As Alzheimer’s disease prevention studies are seeking cognitively healthy but biomarker-positive volunteers, researchers must grapple with ethical implications of divulging amyloid status to symptom-free people. What is the psychological imp
CONFERENCE COVERAGE 2019-05-16 Conference Coverage “There is a lot of bad news, but it’s useful bad news.” This line by Randy Bateman of Washington University, St. Louis, captured the mood at the AD/PD conference held March 27 to 31 in Lisbon, Portugal. Whereas in years past scientists
RESEARCH NEWS 2019-05-29 Research News We can now add myelination to the list of critical functions put on hold by cantankerous microglia. A paper published May 10 in Neuron reported that in mice treated with the widely used chemotherapy drug methotrexate, microglia became activa
RESEARCH NEWS 2019-03-29 Research News In the latest attempt to rid neurons of toxic tau, researchers are trying to harness and improve cells’ own clearance mechanisms. Researchers led by Kenneth Kosik, University of California, Santa Barbara, used a small molecule called lonafar
RESEARCH NEWS 2019-04-11 Research News A new study adds evidence that Alzheimer’s pathology makes nearby cells senescent. Scientists led by Mark Mattson, National Institute on Aging, Baltimore, report in the April 1 Nature Neuroscience that in both people and animals, oligodendro
RESEARCH NEWS 2019-04-19 Research News In the April 17 Science Advances, researchers proffer a new technique for detecting plasma Aβ. Scientists led by Kyo Seon Hwang at Kyung Hee University, Seoul, and YoungSoo Kim at Yonsei University, Incheon, both in the Republic of Korea, de
RESEARCH NEWS 2019-04-21 Research News Microglia are known as the brain’s sometimes-overzealous clean-up crew, but what happens to people if these immune cells are missing from the get-go? Two studies published March 29 in the American Journal of Human Genetics describe nine peop
